Compounds > mirosamicin
Page last updated: 2024-11-11

mirosamicin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

mirosamicin: a mycinamicin; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID49787022
CHEBI ID80018
MeSH IDM0174171

Synonyms (5)

Synonym
mycinamicin ii
73684-69-2
mirosamicin
CHEBI:80018
Q27149164

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Therefore, its LD50 values were estimated to be greater than 2,500 mg/kg for mice and greater than 2,000 mg/kg for rats."( [Acute toxicity studies of miporamicin and its degradation products and metabolites in the mouse and rat].
Matsumoto, K; Motoyama, K; Sano, K; Sasaki, M; Sumi, A; Yamamoto, H; Yano, J, 1989)		0.28
" Histopathologic examination revealed no adverse toxicologic changes other than spontaneous or aging-associated ones."( [Six-month chronic toxicity study of miporamicin in rats].
Matsumoto, K; Miura, M; Morino, T; Motoyama, K; Sumi, A; Yamamoto, H; Yano, J, 1989)		0.28

Dosage Studied

ExcerptRelevanceReference
" Following oral administration of miporamicin (MPM), none died among mice or rats even at the highest dosage levels."( [Acute toxicity studies of miporamicin and its degradation products and metabolites in the mouse and rat].
Matsumoto, K; Motoyama, K; Sano, K; Sasaki, M; Sumi, A; Yamamoto, H; Yano, J, 1989)		0.28
"A 28-day oral dosage test of miporamicin (MPM), a new macrolide antibiotic, was performed to assess its toxicologic potential in groups of male and female rats receiving the compound in feed."( [Subacute toxicity study of miporamicin in rats by twenty-eight-day administration in feed].
Matsumoto, K; Miura, M; Morino, T; Motoyama, K; Sumi, A; Yamamoto, H; Yano, J, 1989)		0.28
" No death occurred at any dosage levels throughout the study period."( [Six-month chronic toxicity study of miporamicin in rats].
Matsumoto, K; Miura, M; Morino, T; Motoyama, K; Sumi, A; Yamamoto, H; Yano, J, 1989)		0.28
" The drug was mixed with pollen-substitute paste and administered to honeybee colonies continuously for a week at a dosage of 200 mg/hive/week."( Disposition of mirosamicin in honeybee hives.
Hayama, T; Nakajima, C; Nakamura, A; Okayama, A; Sakogawa, T, 1998)		0.3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
macrolideA macrocyclic lactone with a ring of twelve or more members derived from a polyketide.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (66.67)18.7374
1990's3 (25.00)18.2507
2000's0 (0.00)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glutaral
Glutaral: One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.. glutaraldehyde : A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.		3.0910dialdehydecross-linking reagent;
disinfectant;
fixative
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Hypercapnic Respiratory Failure
[description not available]		01.9710
Respiratory Insufficiency
Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)		01.9710
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.8940
Fetal Death
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.		01.9710
Abnormalities, Drug-Induced
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.		02.3820
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.3820
Anaphylactic Reaction
[description not available]		01.9710
Contact Dermatitis
[description not available]		01.9710
Anaphylaxis
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.		01.9710
Dermatitis, Contact
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.		01.9710
Abnormalities, Autosome
[description not available]		01.9710