euonine: from Trypterygium wilfordii Hook; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
wilformine : A sesquiterpene alkaloid that has been isolated from Tripterygium wilfordii and exhibits immunosuppressive and insecticidal properties. It was found to be identical with euonine, previously isolated from Euonymous sieboldiana. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Tripterygium | genus | A plant genus of the family CELASTRACEAE that is a source of triterpenoids and diterpene epoxides such as triptolide.[MeSH] | Celastraceae | A plant family of the order Celastrales, subclass Rosidae, class Magnoliopsida.[MeSH] |
| Tripterygium wilfordii | species | [no description available] | Celastraceae | A plant family of the order Celastrales, subclass Rosidae, class Magnoliopsida.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 44584752 |
| CHEMBL ID | 443712 |
| CHEBI ID | 132386 |
| MeSH ID | M0173366 |
| Synonym |
|---|
| wilformine |
| euonine |
| CHEBI:132386 |
| (8alpha)-8-(acetyloxy)-8-deoxoevonimine |
| 41758-69-4 |
| CHEMBL443712 |
| Q27225550 |
| CS-0633921 |
| HY-N10681 |
| FS-7507 |
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| immunosuppressive agent | An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. |
| insecticide | Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| acetate ester | Any carboxylic ester where the carboxylic acid component is acetic acid. |
| dihydroagarofuran sesquiterpenoid | Any sesquiterpenoid with a dihydroagarofuran skeleton. |
| macrolide | A macrocyclic lactone with a ring of twelve or more members derived from a polyketide. |
| pyridine alkaloid | |
| sesquiterpene alkaloid | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID360020 | Immunosuppressive activity in human PBMC assessed as inhibition of LPS-stimulated TNFalpha production at 10 ug/mL after 18 to 24 hrs by ELISA | 2001 | Journal of natural products, May, Volume: 64, Issue:5 | Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii. |
| AID360025 | Immunosuppressive activity in human PBMC assessed as inhibition of LPS-stimulated IFN-gamma production at 10 ug/mL after 18 to 24 hrs by ELISA | 2001 | Journal of natural products, May, Volume: 64, Issue:5 | Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii. |
| AID360023 | Immunosuppressive activity in human PBMC assessed as inhibition of LPS-stimulated IL2 production at 10 ug/mL after 18 to 24 hrs by ELISA | 2001 | Journal of natural products, May, Volume: 64, Issue:5 | Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii. |
| AID360024 | Immunosuppressive activity in human PBMC assessed as inhibition of LPS-stimulated IL4 production at 10 ug/mL after 18 to 24 hrs by ELISA | 2001 | Journal of natural products, May, Volume: 64, Issue:5 | Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii. |
| AID646190 | Antiherpetic activity against HSV2 at 0.5 mg/ml by MTT assay | 2012 | Journal of natural products, Jan-27, Volume: 75, Issue:1 | Dihydroagarofuran derivatives from the dried roots of Tripterygium wilfordii. |
| AID360022 | Immunosuppressive activity in human PBMC assessed as inhibition of LPS-stimulated IL8 production at 10 ug/mL after 18 to 24 hrs by ELISA | 2001 | Journal of natural products, May, Volume: 64, Issue:5 | Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii. |
| AID360021 | Immunosuppressive activity in human PBMC assessed as inhibition of LPS-stimulated IL1-beta production at 10 ug/mL after 18 to 24 hrs by ELISA | 2001 | Journal of natural products, May, Volume: 64, Issue:5 | Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||