ecklonialactone a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

ecklonialactone A: isolated from the brown alga Ecklonia stolonifera; RN given refers to (1aS-(1aR*,2aS*,3R*,10Z,13Z,14aR*,14bS*))-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	23428255
CHEMBL ID	512781
CHEBI ID	168744
MeSH ID	M0230015

Synonyms (4)

Synonym
(1r,2s,9z,12z,14s,15r,17s)-2-ethyl-3,16-dioxatricyclo[12.4.0.015,17]octadeca-9,12-dien-4-one
CHEBI:168744
ecklonialactone a
CHEMBL512781

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
macrolide	A macrocyclic lactone with a ring of twelve or more members derived from a polyketide.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID356495	Antibacterial activity against Staphylococcus aureus after 12 hrs relative to vancomycin	2003	Journal of natural products, Oct, Volume: 66, Issue:10	Novel oxylipin metabolites from the brown alga Eisenia bicyclis.
AID356494	Antibacterial activity against Bacillus subtilis after 12 hrs relative to vancomycin	2003	Journal of natural products, Oct, Volume: 66, Issue:10	Novel oxylipin metabolites from the brown alga Eisenia bicyclis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	2 (40.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (20.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
vancomycin Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.	2.01	1	0	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
rhodium Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.	2.06	1	0	cobalt group element atom
1,1-diphenyl-2-picrylhydrazyl 1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)	3.4	1	1
ecklonialactone b ecklonialactone B: isolated from the brown alga Ecklonia stolonifera; RN refers to (1aS-(1aR,2aS,3R,13Z,14aR,14bS*))-isomer; structure given in first source	2.72	3	0

Condition	Indicated	Relationship Strength	Studies	Trials
Vascular Diseases Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.	0	3.4	1	1

chemdatabank.com