| Assay ID | Title | Year | Journal | Article |
|---|
| AID121997 | Neurotoxic effects by rotarod test in mice. | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor. |
| AID114399 | Anticonvulsant activity in mice by maximal electroshock test. | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor. |
| AID159413 | Dissociation constant from displacement of 35[S]-TBPS binding from picrotoxinin (GABA-A) receptor of rat cerebral cortex | 1994 | Journal of medicinal chemistry, Jan-21, Volume: 37, Issue:2
| Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones. |
| AID71254 | Binding affinity to picrotoxin site of the Gamma-aminobutyric acid receptor was measured using [35S]TBPS as radioligand | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor. |
| AID88596 | Percent response relative to current produced by 1 uM GABA in rat hippocampal cells | 1994 | Journal of medicinal chemistry, Jan-21, Volume: 37, Issue:2
| Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones. |
| AID114400 | Anticonvulsant activity in mice by inhibition of pentylenetetrazole induced seizures. | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor. |
| AID159410 | Maximum Binding affinity for picrotoxinin (GABA-A) receptor of rat cerebral cortex | 1994 | Journal of medicinal chemistry, Jan-21, Volume: 37, Issue:2
| Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones. |
| AID131531 | Effective dose at which 50% of the mice were protected from clonic seizures induced by pentylenetetrazole (85 mg/kg) | 1994 | Journal of medicinal chemistry, Jan-21, Volume: 37, Issue:2
| Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones. |
| AID159411 | Displacement of 35[S]-TBPS from picrotoxinin (GABA-A) receptor of rat neuronal membranes | 1994 | Journal of medicinal chemistry, Jan-21, Volume: 37, Issue:2
| Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones. |
| AID212212 | Dose at which 50% of the mice failed the rotarod neurotoxicity test | 1994 | Journal of medicinal chemistry, Jan-21, Volume: 37, Issue:2
| Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |