2,5-dideoxy-2,5-imino-D-glucitol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 445074 |
| CHEMBL ID | 259905 |
| SCHEMBL ID | 4319863 |
| MeSH ID | M0502392 |
| Synonym |
|---|
| 2,5-dideoxy-2,5-imino-d-glucitol |
| CHEMBL259905 , |
| (2r,3r,4r,5s)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol |
| SCHEMBL4319863 |
| bdbm50234564 |
| 2,5-anhydro-2,5-imino-d-glucitol |
| 132295-44-4 |
| W-201072 |
| 2,5-pyrrolidinedimethanol, 3,4-dihydroxy-, (2s,3r,4r,5r)- |
| Q63390510 |
| (+)-2,5-dideoxy-2,5-imino-d-glucitol |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Lysosomal alpha-glucosidase | Homo sapiens (human) | IC50 (µMol) | 300.0000 | 0.0600 | 2.2889 | 7.8000 | AID403083 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 (µMol) | 617.5000 | 0.0400 | 1.8483 | 10.0000 | AID324679; AID324680; AID403086; AID403087 |
| Glycogen debranching enzyme | Homo sapiens (human) | IC50 (µMol) | 11.0000 | 8.4000 | 9.5143 | 10.0000 | AID324673 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID324673 | Inhibition of amylo-1,6-glucosidase | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6 | Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases. |
| AID403087 | Inhibition of rat intestinal isomaltase | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8 | Iminosugar-producing Thai medicinal plants. |
| AID403085 | Inhibition of almond beta-glucosidase | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8 | Iminosugar-producing Thai medicinal plants. |
| AID324679 | Inhibition of rat isomaltase | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6 | Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases. |
| AID403083 | Inhibition of alpha-glucosidase | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8 | Iminosugar-producing Thai medicinal plants. |
| AID324672 | Inhibition of rabbit muscle glycogen phosphorylase b at 400 uM | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6 | Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases. |
| AID403086 | Inhibition of rat intestinal sucrase | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8 | Iminosugar-producing Thai medicinal plants. |
| AID403084 | Inhibition of beta-glucosidase | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8 | Iminosugar-producing Thai medicinal plants. |
| AID324680 | Inhibition of rat sucrase | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6 | Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases. |
| AID324677 | Inhibition of yeast alpha-glucosidase | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6 | Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.41) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||