Compounds > tadalafil
Page last updated: 2024-09-02

tadalafil and paroxetine

tadalafil has been researched along with paroxetine in 6 studies

Compound Research Comparison

Studies
(tadalafil)		Trials
(tadalafil)		Recent Studies (post-2010)
(tadalafil)		Studies
(paroxetine)		Trials
(paroxetine)		Recent Studies (post-2010) (paroxetine)
1,7423921,0894,2571,0311,031

Protein Interaction Comparison

ProteinTaxonomytadalafil (IC50)paroxetine (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)3.9
MyeloperoxidaseHomo sapiens (human)0.02
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.086
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.532
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.244
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.123
Quinolone resistance protein NorAStaphylococcus aureus7
Cytochrome P450 2D6Homo sapiens (human)0.5003
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.145
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.179
Beta-adrenergic receptor kinase 1Bos taurus (cattle)1.08
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.093
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)0.623
Beta-adrenergic receptor kinase 1Homo sapiens (human)1.24
Substance-P receptorHomo sapiens (human)0.9
Sodium-dependent serotonin transporterHomo sapiens (human)0.0007
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.0003
P2X purinoceptor 4Rattus norvegicus (Norway rat)2.45
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)3.9
Sodium-dependent dopamine transporter Homo sapiens (human)0.672
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)3.9
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)3.9
P2X purinoceptor 4Homo sapiens (human)2.8067
Sigma non-opioid intracellular receptor 1Homo sapiens (human)5.366
TransporterRattus norvegicus (Norway rat)0.535

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Dalvie, D; Loi, CM; Smith, DA1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Otunctemur, A; Ozbek, E; Ozcan, L; Polat, EC; Simsek, A1
Amani, F; Hosseinkhani, A; Mohseni Rad, H; Nima Soluki, N; Zahirian Moghadam, T1
Can, O; Culha, MG; Ermec, B; Onal, B1

Reviews

1 review(s) available for tadalafil and paroxetine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for tadalafil and paroxetine

ArticleYear
Combination therapy with selective serotonin reuptake inhibitors and phosphodiesterase-5 inhibitors in the treatment of premature ejaculation.
    Andrologia, 2015, Volume: 47, Issue:5

    Topics: Adult; Drug Therapy, Combination; Humans; Male; Paroxetine; Phosphodiesterase 5 Inhibitors; Premature Ejaculation; Selective Serotonin Reuptake Inhibitors; Tadalafil; Treatment Outcome; Young Adult

2015
Comparison of Dapoxetine /Tadalafil and Paroxetine/Tadalafil Combination Therapies for the Treatment of the Premature Ejaculation: A Randomized Clinical Trial.
    Urology journal, 2021, Nov-13, Volume: 19, Issue:2

    Topics: Benzylamines; Ejaculation; Humans; Male; Naphthalenes; Paroxetine; Premature Ejaculation; Selective Serotonin Reuptake Inhibitors; Tadalafil; Treatment Outcome

2021

Other Studies

3 other study(ies) available for tadalafil and paroxetine

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Which metabolites circulate?
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5

    Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations

2013
Retrospective evaluation of the efficacy of daily paroxetine/tadalafil combination in patients with premature ejaculation and erectile dysfunction.
    European review for medical and pharmacological sciences, 2023, Volume: 27, Issue:9

    Topics: Ejaculation; Erectile Dysfunction; Female; Humans; Male; Paroxetine; Phosphodiesterase 5 Inhibitors; Premature Ejaculation; Retrospective Studies; Tadalafil; Treatment Outcome

2023