| Assay ID | Title | Year | Journal | Article |
|---|
| AID208101 | Effective dose concentration required for In vivo binding affinity towards Tachykinin receptor 1 after oral administration in presence of agonist ASMSP in guinea pig pulmonary tissue in lung plasma extravation assay | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID13141 | Bioavailability by oral administration at a dose of 100 uM/kg in rat was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID208570 | Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID11626 | Maximum concentration by oral administration at a dose of 100 umol/kg in rat was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID212245 | Binding affinity against human cloned Tachykinin receptor 3 expressed in MEL cells | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID145489 | In vivo efficacy expressed as dose ratio for bronchoconstriction induced by ASMSP as agonist for NK1 receptor in anesthetized guinea pig | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID26480 | Bioavailability in rat (dose 1-10 uM/kg i.v.) | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID9910 | Volume distribution at a dose of 1 uM/kg in dog was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID208103 | Effective dose of concentration required for In vivo potency (ED50 ratio for Tachykinin receptor 1 in presence and absence of antagonist) in guinea pig PMM after intravenous administration at a dose 10 uM/Kg | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID10888 | Tmax by oral administration at a dose of 100 uM/kg in rat was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID211330 | Binding constant towards tachykinin receptor 1 using ASMSP as agonist on rabbit pulmonary artery tissues. | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID211885 | Binding constant towards Tachykinin receptor 2 using NKA as agonist on human bronchus | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID211905 | Tested for the binding affinity towards tachykinin receptor 2 (NK2) in rabbit pulmonary artery tissue | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID12148 | Area under curve by intravenous administration at a dose of 10 uM/kg in rat was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID26479 | Bioavailability in dog (dose 1-10 uM/kg i.v.) | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID8921 | Maximum concentration by oral administration at a dose of 10 umol/kg in dog was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID211512 | Effective dose of concentration required for In vivo potency (ED50 ratio for Tachykinin receptor 2 in presence and absence of antagonist) in guinea pig PMM after intravenous administration at a dose 10 uM/Kg | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID212251 | Inhibition of binding of [125I]MPNI to human Tachykinin receptor 3 (NK3) expressed in mouse erythroleukemia cells | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID8138 | Area under curve by oral administration at a dose of 10 uM/kg in dog was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID211719 | Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID208581 | Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID10275 | Half life period at a dose of 1 uM/kg in dog was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID211874 | Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID9743 | Tmax by oral administration at a dose of 10 uM/kg in dog was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID208595 | Binding constant towards Tachykinin receptor 1 using ASMSP as agonist on human pulmonary artery tissues | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID211511 | Effective dose of concentration required for In vivo potency (ED50 ratio for Tachykinin receptor 2 (NK2) in presence and absence of antagonist) in guinea pig PMM after oral administration at a dose 30 uM/Kg | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID211901 | Binding constant towards Tachykinin receptor 2 using BANK as agonist on rabbit pulmonary artery tissues. | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID10797 | Plasma clearance in rat at a dose of 10 uM/kg in rat was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID10796 | Plasma clearance in dog at a dose of 1 uM/kg in rat was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID211332 | In vitro binding affinity towards Tachykinin receptor 1 was determined using rabbit pulmonary artery tissues | 2004 | Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
| Structural analysis and optimization of NK(1) receptor antagonists through modulation of atropisomer interconversion properties. |
| AID208102 | Effective dose of concentration required for In vivo potency (ED50 ratio for NK1 in presence and absence of antagonist) in guinea pig PMM after oral administration at a dose 30 uM/Kg | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID10285 | Half-life period by oral administration at a dose of 10 uM/kg in dog was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID12484 | Half life period at a dose of 10 uM/kg in rat was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID145618 | In vivo efficacy expressed as dose ratio for bronchoconstriction induced by BANK as agonist for NK2 receptor in anesthetized guinea pig at 30 uM/kg dose by oral administration | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID211903 | In vitro binding affinity towards Tachykinin receptor 2 using rabbit pulmonary artery tissues | 2004 | Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
| Structural analysis and optimization of NK(1) receptor antagonists through modulation of atropisomer interconversion properties. |
| AID8357 | Bioavailability by oral administration at a dose of 10 uM/kg in dog was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID11124 | Volume distribution at a dose of 10 uM/kg in rat was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID12149 | Area under curve by oral administration at a dose of 100 uM/kg in rat was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID12485 | Half life period by oral administration at a dose of 100 uM/kg in rat was determined; ND is not determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID8137 | Area under curve by intravenous administration at a dose of 1 uM/kg in dog was determined | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Discovery of novel, orally active dual NK1/NK2 antagonists. |
| AID211509 | Effective dose concentration required for In vivo binding affinity towards Tachykinin receptor 2 (NK2) receptor after oral administration in presence of agonist ASMSP in guinea pig pulmonary tissue in lung plasma extravation assay | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID211334 | Tested for the binding affinity towards tachykinin receptor 1 (NK1) in rabbit pulmonary artery tissue | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18
| Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. |
| AID1346346 | Human NK1 receptor (Tachykinin receptors) | 2001 | The Journal of pharmacology and experimental therapeutics, Jul, Volume: 298, Issue:1
| Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |