Compounds > verrucarin e
Page last updated: 2024-11-07

verrucarin e

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Verrucarin E is a mycotoxin produced by the fungus Myrothecium verrucaria. It has been shown to exhibit a range of biological activities, including cytotoxic, antifungal, and immunosuppressive effects. Verrucarin E has been studied extensively for its potential therapeutic applications, particularly in the treatment of cancer. Its cytotoxic effects are attributed to its ability to inhibit protein synthesis and induce apoptosis in cancer cells. Due to its potent biological activities, Verrucarin E has also been investigated for its potential use in the development of novel antifungal and immunosuppressive drugs. The synthesis of verrucarin E is a complex process involving multiple steps and is typically carried out using chemical methods. The compound is of significant interest to researchers due to its potent biological activities and its potential for therapeutic applications.'

Cross-References

ID SourceID
PubMed CID100243
CHEMBL ID1966107
MeSH IDM0058863

Synonyms (17)

Synonym
24445-13-4
4-acetyl-3-hydroxymethylpyrrole
nsc-270675
ethanone, 1-[4-(hydroxymethyl)-1h-pyrrol-3-yl]-
nsc270675
NCI60_002213
verrucarin e
1-[4-(hydroxymethyl)-1h-pyrrol-3-yl]ethanone
AKOS006347276
ethanone, 1-(4-(hydroxymethyl)-1h-pyrrol-3-yl)-
unii-m8m1g6524e
m8m1g6524e ,
1-(4-(hydroxymethyl)-1h-pyrrol-3-yl)ethanone
nsc 270675
CHEMBL1966107
DTXSID00179205
Q27283654
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (3)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (66.67)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.19 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.19)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.		1.9610antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.6630pyrrole;
secondary amine
anisomycin
Anisomycin: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.. (-)-anisomycin : An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.		1.9610monohydroxypyrrolidine;
organonitrogen heterocyclic antibiotic		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
antiparasitic agent;
bacterial metabolite;
DNA synthesis inhibitor;
protein synthesis inhibitor
sesquiterpenes
[no description available]		1.9610
trichodermin
Trichodermin: Antifungal metabolite from several fungi, mainly Trichoderma viride; inhibits protein synthesis by binding to ribosomes; proposed as antifungal and antineoplastic; used as tool in cellular biochemistry.. trichodermin : A tetracyclic spiroepoxide which acts as an antifungal and protein synthesis inhibitor.		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials