sudoterb: an antibacterial active against M. tuberculosis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6479837 |
| CHEMBL ID | 2024190 |
| SCHEMBL ID | 4180312 |
| MeSH ID | M0527864 |
| Synonym |
|---|
| ll3858 |
| n-(3-{[4-(3-trifluoromethylphenyl)piperazinyl]methyl}-2-methyl-5-phenyl-pyrrolyl)-4-pyridylcarboxamide |
| n-[2-methyl-5-phenyl-3-[[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]pyrrol-1-yl]pyridine-4-carboxamide |
| ll-3858 |
| sudoterb(tm) |
| sudoterb |
| CHEMBL2024190 |
| 4-pyridinecarboxamide, n-(2-methyl-5-phenyl-3-((4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)methyl)-1h-pyrrol-1-yl)- |
| sk2537665a , |
| unii-sk2537665a |
| 676266-31-2 |
| n-{2-methyl-5-phenyl-3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-ylmethyl]-pyrrol-1-yl}-isonicotinamide |
| SCHEMBL4180312 |
| DTXSID50217949 |
| AKOS032947370 |
| ll3858; ll-3858; ll 385 |
| BCP18265 |
| 676266-31-2 (free base) |
| sudoterb free base |
| 4-pyridinecarboxamide, n-[2-methyl-5-phenyl-3-[[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]methyl]-1h-pyrrol-1-yl]- |
| ll 3858 free base;ll 4858 free base;pyrrole ll 3858 free base |
| sudoterb (free base) |
| Q27289249 |
| n-(2-methyl-5-phenyl-3-((4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl)-1h-pyrrol-1-yl)isonicotinamide |
| HY-14990 |
| CS-0003681 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The main pharmacokinetic parameters after intravenous administration (10 mg/kg body weight) in male Wistar rats viz." | ( Synthesis of highly potent novel anti-tubercular isoniazid analogues with preliminary pharmacokinetic evaluation. Indira, VL; Jeankumar, VU; Karyavardhi, G; Manjashetty, TH; Monika, A; Ramani, AV; Sriram, D; Venkatesh, J; Yogeeswari, P, 2012) | 0.38 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The bioavailability was found to be 16." | ( Synthesis of highly potent novel anti-tubercular isoniazid analogues with preliminary pharmacokinetic evaluation. Indira, VL; Jeankumar, VU; Karyavardhi, G; Manjashetty, TH; Monika, A; Ramani, AV; Sriram, D; Venkatesh, J; Yogeeswari, P, 2012) | 0.38 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID657972 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8 | Synthesis of highly potent novel anti-tubercular isoniazid analogues with preliminary pharmacokinetic evaluation. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 3 (60.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 2 (40.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||