Compounds > pyridoacridine
Page last updated: 2024-11-13

pyridoacridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pyridoacridine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID87157943
SCHEMBL ID789542
MeSH IDM0452101

Synonyms (3)

Synonym
benzo[b][4,7]phenanthroline
pyridoacridine
SCHEMBL789542

Research Excerpts

Overview

Pyridoacridines are a class of strictly marine-derived alkaloids. They constitute one of the largest chemical families of marine alkaloid.

ExcerptReferenceRelevance
"Pyridoacridines are a class of strictly marine-derived alkaloids that constitute one of the largest chemical families of marine alkaloids. "( Marine Pyridoacridine Alkaloids: Biosynthesis and Biological Activities.
Ibrahim, SR; Mohamed, GA, 2016)		2.33

Toxicity

ExcerptReferenceRelevance
" Neoamphimedine exhibited enhanced toxicity in top2 over-expressing yeast cells and was toxic in every mammalian cell line tested."( The anti-neoplastic and novel topoisomerase II-mediated cytotoxicity of neoamphimedine, a marine pyridoacridine.
Barrows, LR; Concepción, GP; Holden, JA; Ireland, CM; Marshall, KM; Matsumoto, SS; Tasdemir, D, 2003)		0.54
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (14.29)18.7374
1990's0 (0.00)18.2507
2000's12 (42.86)29.6817
2010's9 (32.14)24.3611
2020's3 (10.71)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.95

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.95 (24.57)
Research Supply Index3.37 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.95)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acridines
Acridines: Compounds that include the structure of acridine.. acridine : A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom.		6.88280acridines;
mancude organic heterotricyclic parent;
polycyclic heteroarene		genotoxin
thiazoles
[no description available]		2.11101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
kynuramine
Kynuramine: An aromatic ketone containing the aniline structure (ANILINE COMPOUNDS).. kynuramine : A member of the class of kynurenamines that is aniline substituted at position 2 by a 3-aminopropanoyl group.		7.3110kynurenamines;
primary amino compound		metabolite
2-iodobenzenamine
2-iodobenzenamine: structure in first source		2.110
fluorine
Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.		6.9210diatomic fluorine;
gas molecular entity		NMR chemical shift reference compound
fluorides
[no description available]		1.9210halide anion;
monoatomic fluorine
1,7-phenanthroline
[no description available]		6.59270phenanthroline
ethylnicotinate
[no description available]		2.110aromatic carboxylic acid;
pyridines
meridine
meridine: polycyclic alkaloid derived from the marine sponge Corticium sp; structure given in first source		7.0210
amphimedine
amphimedine: structure in first source		4.0640
eilatine
eilatine: isolated from the Red Sea purple tunicate Eudistoma sp.; structure given in first source		2.0510
ascididemin
ascididemin: can be viewed as a fused phenanthroline with quinoline; from the Mediterranean ascidian Cystodytes dellechiajei; structure in first source		4.0340
lithium
Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.		2.110alkali metal atom
neoamphimedine
neoamphimedine: a Pyrido[4,3,2-mn]acridine from Indo-Pacific sponge genus Xestospongia; structure in first source		7.0110
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Plasmodium
[description not available]		01.9210
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		06.9210
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		02.0110
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		07.0110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0110
Experimental Neoplasms
[description not available]		02.0110