pyridoacridine has been researched along with meridine* in 1 studies
1 other study(ies) available for pyridoacridine and meridine
Article | Year |
---|---|
Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine.
A series of cycle C and D-substituted phenanthrolin-7-ones, analogues of the marine pyridoacridines meridine and ascididemin have been synthesized on the basis of Diels-Alder reactions involving quinoline-5,8-dione and 2- (or un)-substituted-N,N-dimethylhydrazones. All the compounds were evaluated for in vitro cytotoxic activity against 12 distinct human cancer cell lines. They all exhibit cytotoxic activity with IC(50) values at least of micromolar order. Topics: Acridines; Alkaloids; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Phenanthrolines; Quinolines; Structure-Activity Relationship | 2004 |