pyridoacridine has been researched along with Cell-Transformation--Neoplastic* in 1 studies
1 other study(ies) available for pyridoacridine and Cell-Transformation--Neoplastic
| Article | Year |
|---|---|
Pyridoacridine alkaloids inducing neuronal differentiation in a neuroblastoma cell line, from marine sponge Biemna fortis.
A new and three known pyridoacridine alkaloids were isolated from the Indonesian marine sponge Biemna fortis as neuronal differentiation inducers against a murine neuroblastoma cell line, Neuro 2A. The chemical structure of the new compound, labuanine A (1), was determined by spectroscopic study and chemical conversion. These pyridoacridine alkaloids induced multipolar neuritogenesis in more than 50% of cells at 0.03-3 micro M concentration. Compound 3, which showed the strongest neuritogenic activity among them, also induced increase of acetylcholinesterase, a neuronal marker in Neuro 2A and arrested cell cycle at the G2/M phase. Topics: Acridines; Alkaloids; Animals; Cell Differentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Mice; Neuroblastoma; Neurons; Phenanthrolines; Porifera | 2003 |