pyridoacridine has been researched along with ascididemin* in 4 studies
1 review(s) available for pyridoacridine and ascididemin
| Article | Year |
|---|---|
Biological activities of pyridoacridines.
This review consolidates biological activity data reported for pyridoacridine 1 molecules in the literature from 1983-2003 into several tables with brief discussions of assays used and results obtained. This review summarizes recent progress in structure activity relationships for analogues of amphimedine 2 and ascididemin 3 classes of pyridoacridines and correlates reported molecular mechanisms of action with biological activities. Topics: Acridines; Alkaloids; Antifungal Agents; Antineoplastic Agents; Antiparasitic Agents; Antiviral Agents; DNA; Phenanthrolines; Quinolines | 2004 |
3 other study(ies) available for pyridoacridine and ascididemin
| Article | Year |
|---|---|
Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine.
A series of cycle C and D-substituted phenanthrolin-7-ones, analogues of the marine pyridoacridines meridine and ascididemin have been synthesized on the basis of Diels-Alder reactions involving quinoline-5,8-dione and 2- (or un)-substituted-N,N-dimethylhydrazones. All the compounds were evaluated for in vitro cytotoxic activity against 12 distinct human cancer cell lines. They all exhibit cytotoxic activity with IC(50) values at least of micromolar order. Topics: Acridines; Alkaloids; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Phenanthrolines; Quinolines; Structure-Activity Relationship | 2004 |
Antiparasitic activity of marine pyridoacridone alkaloids related to the ascididemins.
A series of pyridoacridone alkaloids, including the marine alkaloid ascididemin were tested in vitro for antiparasitic activity against P. falciparum (K1, NF54), L. donovani, T. cruzi, T. b. rhodesiense and two mammalian cell lines (L6, RAW 264.7). Most compounds showed high antiplasmodial activity, moderate antileishmanial activity against both extra- and intracellular forms, and significant trypanocidal effects against T. cruzi and T. b. brucei. However, when tested against mammalian cell lines, most of the compounds were also toxic for macrophage-like RAW 264.7 cells and skeletal muscle myoblast L6 cells. Correlations between molecular structures and antiparasitic activity are discussed in detail. Specific compounds are illustrated with emphasis on their potential as new antiparasitic drug leads. Topics: Acridines; Alkaloids; Animals; Antiprotozoal Agents; Cell Line; Leishmania donovani; Macrophages; Mice; Microbial Sensitivity Tests; Muscle, Skeletal; Myoblasts; Parasitic Sensitivity Tests; Phenanthrolines; Phytotherapy; Plasmodium falciparum; Quinolines; Rats; Structure-Activity Relationship; Trypanosoma; Trypanosoma brucei brucei; Trypanosoma cruzi; Urochordata | 2003 |
Synthesis and in vitro antitumor activity of an isomer of the marine pyridoacridine alkaloid ascididemin and related compounds.
The isomer (9H-quino[4,3,2-de][1,7]phenanthroline-9-one) (2) of the marine alkaloid ascididemin (9H-quino[4,3,2-de][1,10]phenanthroline-9-one) (1) has been synthesized in six steps from 1,4-dimethoxyacridine (10) with an overall yield of 12%. Different related compounds were prepared and tested in vitro at six different concentrations on 12 different human cancer cell lines of various histopathological types (glioblastomas and breast, colon, lung, prostate and bladder cancers). Almost all the compounds present cytotoxic activity of micromolar order. Topics: Acridines; Alkaloids; Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Isomerism; Marine Biology; Phenanthrolines; Quinolines; Structure-Activity Relationship; Urochordata | 2003 |