o(6)-ethyl-2'-deoxyguanosine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

O(6)-ethyl-2'-deoxyguanosine: formed in DNA exposed to ethylnitrosourea [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

O(6)-ethyl-2'-deoxyguanosine : A purine 2'-deoxyribonucleoside having O(6)-ethylguanine as the nucleobase. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	99549
CHEBI ID	61013
SCHEMBL ID	7512181
MeSH ID	M0070162

Synonyms (22)

Synonym
o(6)-ethyl-2'-deoxyguanosine
o(6)-ethyldeoxyguanosine
9-(2-deoxy-beta-d-erythro-pentofuranosyl)-6-ethoxy-9h-purin-2-amine
2'-deoxy-o(6)-ethylguanosine
CHEBI:61013 ,
50704-46-6
nsc-240591
SCHEMBL7512181
nsc 240591
ug1b1h0fl4 ,
9h-purin-2-amine, 9-(2-deoxy-beta-d-erythro-pentofuranosyl)-6-ethoxy-
unii-ug1b1h0fl4
EPITOPE ID:146098
mfcd00800198
AQRYUWBBKDNOHV-XLPZGREQSA-N
o6 -ethyldeoxyguanosine
o6-ethyl-deoxyguanosine
o6-ethyldeoxyguanosine
Q27130565
2'-deoxy-6-o-ethylguanosine
guanosine, 2'-deoxy-6-o-ethyl-
(2r,3s,5r)-5-(2-amino-6-ethoxy-9h-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
purine 2'-deoxyribonucleoside	A 2'-deoxyribonucleoside that has a purine moiety as the nucleobase (the R group in the illustration).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (13)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	11 (84.62)	18.7374
1990's	1 (7.69)	18.2507
2000's	1 (7.69)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.52

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.52 (24.57)
Research Supply Index	2.64 (2.92)
Research Growth Index	4.16 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.52)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
thymine [no description available]	1.97	1	pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite
thymidine [no description available]	1.96	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
2-acetylaminofluorene 2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.	2.37	2	2-acetamidofluorenes	antimitotic; carcinogenic agent; epitope; mutagen
diethylnitrosamine Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.	2.37	2	nitrosamine	carcinogenic agent; hepatotoxic agent; mutagen
ethylnitrosourea Ethylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-ethyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.	3.21	6	N-nitrosoureas	alkylating agent; carcinogenic agent; genotoxin; mutagen
o(6)-methyl-2'-deoxyguanosine O(6)-methyl-2'-deoxyguanosine: RN given refers to (beta)-isomer. O(6)-methyl-2'-deoxyguanosine : A purine 2'-deoxyribonucleoside having O(6)-methylguanine as the nucleobase.	2.67	3	purine 2'-deoxyribonucleoside
4-ethylthymine [no description available]	1.97	1
o(4)-ethylthymidine O(4)-ethylthymidine: accumulates in hepatocyte DNA of rats exposed to diethylnitrosamine	1.96	1
deoxyguanosine [no description available]	3.91	13	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
n-(deoxyguanosin-8-yl)acetylaminofluorene N-(deoxyguanosin-8-yl)-2-acetylaminofluorene : Guanosine substituted at the purine 8-position by an acetyl(9H-fluoren-2-yl)amino group.	2.37	2	guanosines
phosphorus radioisotopes Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.	1.97	1

Condition	Relationship Strength	Studies
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.03	1
Cancer of Liver [description not available]	1.97	1
Liver Neoplasms Tumors or cancer of the LIVER.	1.97	1

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