O-acetylcamptothecin: RN given for (S)-isomer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 9886692 |
| CHEMBL ID | 430750 |
| SCHEMBL ID | 5697379 |
| MeSH ID | M0255085 |
| Synonym |
|---|
| 7688-64-4 |
| nsc-95382 |
| CHEMBL430750 |
| o-acetylcamptothecin |
| (s)-4-(acetyloxy)4-ethyl-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione |
| camptothecin-20(s)-acetate |
| 1v364427ug , |
| unii-1v364427ug |
| nsc 95382 |
| 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4-(acetyloxy)-4-ethyl-, (s)- |
| camptothecin-20-acetate |
| camptothecine, acetate (ester) |
| 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4-(acetyloxy)-4-ethyl-, (4s)- |
| camptothecin acetate [mi] |
| camptothecin acetate, (+)- |
| 20-o-acetylcamptothecin |
| o-acetylcamptothecine |
| camptothecin acetate |
| 20(s)-camptothecin acetate |
| SCHEMBL5697379 |
| Q27252932 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID25443 | Half life in human plasma at 37 degree C; Not determined | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10 | Drug delivery systems. 2. Camptothecin 20-O-poly(ethylene glycol) ester transport forms. |
| AID25447 | Half life in rat plasma at 37 degree C; Not determined | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10 | Drug delivery systems. 2. Camptothecin 20-O-poly(ethylene glycol) ester transport forms. |
| AID25441 | Half life in deionized water at 37 degree C; Not determined | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10 | Drug delivery systems. 2. Camptothecin 20-O-poly(ethylene glycol) ester transport forms. |
| AID56564 | Concentration that produces 50% DNA cleavage mediated by DNA topoisomerase I; neg= negative is no enzyme mediated DNA cleavage at the highest conc tested at 50 uM | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity. |
| AID25438 | Half life in PBS buffer (pH 7.4) at 37 degree C (DMSO employed as cosolvent) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10 | Drug delivery systems. 2. Camptothecin 20-O-poly(ethylene glycol) ester transport forms. |
| AID98164 | Concentration that inhibits the proliferation of L1210 cells by 50% | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.59) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||