glucose 6-phosphate:phosphate antiporter activity

Definition

Target type: molecularfunction

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out). [GOC:dph, PMID:18337460]

Glucose 6-phosphate:phosphate antiporter activity involves the transmembrane transport of glucose 6-phosphate and inorganic phosphate across a cellular membrane. This transport is coupled, meaning that the movement of one molecule is dependent on the simultaneous movement of the other. The antiporter mechanism signifies that the two molecules move in opposite directions across the membrane. This activity is crucial for maintaining cellular energy balance and glucose homeostasis. It plays a role in:

1. **Glucose metabolism:** The antiporter facilitates the entry of glucose 6-phosphate into the cytoplasm, where it can be utilized in glycolysis for ATP production.

2. **Phosphate transport:** The antiporter enables the transport of inorganic phosphate, an essential component of ATP and other biomolecules, across the membrane.

3. **Regulation of intracellular glucose levels:** By facilitating the exchange of glucose 6-phosphate for phosphate, the antiporter helps to regulate the concentration of glucose 6-phosphate within the cell.

4. **Maintaining cellular pH:** The antiporter can contribute to the maintenance of cellular pH by regulating the intracellular concentration of phosphate.

5. **Signal transduction:** The activity of the glucose 6-phosphate:phosphate antiporter can be influenced by various cellular signals, allowing it to play a role in cellular signaling pathways.'
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Proteins (2)

Compounds (2)