| ID Source | ID |
|---|---|
| PubMed CID | 9905972 |
| CHEMBL ID | 155917 |
| SCHEMBL ID | 2943813 |
| MeSH ID | M0302339 |
| Synonym |
|---|
| ml-10375 |
| 2-(3,5-dimethylpiperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate |
| gtpl249 |
| ml 10375 |
| L014506 |
| CHEMBL155917 , |
| 4-amino-5-chloro-2-methoxy-benzoic acid 2-(3,5-dimethyl-piperidin-1-yl)-ethyl ester |
| bdbm50056392 |
| ml10375 |
| SCHEMBL2943813 |
| Q27086949 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 1.0000 | AID5880 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 1.0000 | AID5880 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID624238 | Antagonists at Human 5-Hydroxytryptamine receptor 5-HT4 | 1998 | Journal of neurochemistry, Jun, Volume: 70, Issue:6 ISSN: 0022-3042 | Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. |
| AID624238 | Antagonists at Human 5-Hydroxytryptamine receptor 5-HT4 | 2000 | British journal of pharmacology, Oct, Volume: 131, Issue:4 ISSN: 0007-1188 | Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells. |
| AID1346953 | Human 5-HT4 receptor (5-Hydroxytryptamine receptors) | 2000 | British journal of pharmacology, Feb, Volume: 129, Issue:4 ISSN: 0007-1188 | Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines. |
| AID624238 | Antagonists at Human 5-Hydroxytryptamine receptor 5-HT4 | 2000 | British journal of pharmacology, Jun, Volume: 130, Issue:3 ISSN: 0007-1188 | Exploration of the ligand binding site of the human 5-HT(4) receptor by site-directed mutagenesis and molecular modeling. |
| AID1346953 | Human 5-HT4 receptor (5-Hydroxytryptamine receptors) | 2000 | British journal of pharmacology, Oct, Volume: 131, Issue:4 ISSN: 0007-1188 | Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells. |
| AID1346953 | Human 5-HT4 receptor (5-Hydroxytryptamine receptors) | 2000 | British journal of pharmacology, Jun, Volume: 130, Issue:3 ISSN: 0007-1188 | Exploration of the ligand binding site of the human 5-HT(4) receptor by site-directed mutagenesis and molecular modeling. |
| AID624238 | Antagonists at Human 5-Hydroxytryptamine receptor 5-HT4 | 2004 | British journal of pharmacology, Nov, Volume: 143, Issue:5 ISSN: 0007-1188 | The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. |
| AID1346953 | Human 5-HT4 receptor (5-Hydroxytryptamine receptors) | 1998 | Journal of neurochemistry, Jun, Volume: 70, Issue:6 ISSN: 0022-3042 | Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. |
| AID1346953 | Human 5-HT4 receptor (5-Hydroxytryptamine receptors) | 2004 | British journal of pharmacology, Nov, Volume: 143, Issue:5 ISSN: 0007-1188 | The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. |
| AID624238 | Antagonists at Human 5-Hydroxytryptamine receptor 5-HT4 | 2000 | British journal of pharmacology, Feb, Volume: 129, Issue:4 ISSN: 0007-1188 | Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines. |
| AID6239 | Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand | 1997 | Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4 ISSN: 0022-2623 | New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. |
| AID5880 | Binding affinity was measured on 5-hydroxytryptamine 3 receptor using [3H]-BRL 43694 as radioligand in rat posterior cortex. | 1997 | Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4 ISSN: 0022-2623 | New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. |
| AID6143 | 5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum; Inactive up to 10E-5 M | 1997 | Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4 ISSN: 0022-2623 | New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. |
| AID6152 | 5-hydroxytryptamine 4 receptor antagonist activity, concentration which gave 50% reduction of the 5-HT-induced contractions in the guinea pig ileum | 1997 | Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4 ISSN: 0022-2623 | New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Glial Cell Tumors | 0 | 2000 | 2000 | 24.0 | high | 0 | 0 | 1 | 0 | 0 | 0 | |
| Glioma | 0 | 2000 | 2000 | 24.0 | high | 0 | 0 | 1 | 0 | 0 | 0 | |
| Muscle Contraction | 0 | 2004 | 2004 | 20.0 | high | 0 | 0 | 0 | 1 | 0 | 0 |
| Article | Year |
|---|---|
| The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. British journal of pharmacology, , Volume: 143, Issue:5 | 2004 |