Page last updated: 2024-11-12

ml 10375

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID9905972
CHEMBL ID155917
SCHEMBL ID2943813
MeSH IDM0302339

Synonyms (11)

Synonym
ml-10375
2-(3,5-dimethylpiperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate
gtpl249
ml 10375
L014506
CHEMBL155917 ,
4-amino-5-chloro-2-methoxy-benzoic acid 2-(3,5-dimethyl-piperidin-1-yl)-ethyl ester
bdbm50056392
ml10375
SCHEMBL2943813
Q27086949

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"3 or 1 mg kg(-1)) inhibited contractions of the stomach fundus in anaesthetized rats in response to intravenous dosing of alpha-methyl 5-HT (0."( The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo.
Armstrong, SR; Beattie, DT; Humphrey, PP; Mai, N; Marquess, D; McCullough, JL; Pulido-Rios, T; Richardson, C; Sandlund, C; Smith, JA; Vickery, RG, 2004
)
0.32
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)Ki1.00000.00020.484110.0000AID5880
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)Ki1.00000.00020.502310.0000AID5880
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID624238Antagonists at Human 5-Hydroxytryptamine receptor 5-HT41998Journal of neurochemistry, Jun, Volume: 70, Issue:6
Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus.
AID624238Antagonists at Human 5-Hydroxytryptamine receptor 5-HT42000British journal of pharmacology, Oct, Volume: 131, Issue:4
Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells.
AID1346953Human 5-HT4 receptor (5-Hydroxytryptamine receptors)2000British journal of pharmacology, Feb, Volume: 129, Issue:4
Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines.
AID624238Antagonists at Human 5-Hydroxytryptamine receptor 5-HT42000British journal of pharmacology, Jun, Volume: 130, Issue:3
Exploration of the ligand binding site of the human 5-HT(4) receptor by site-directed mutagenesis and molecular modeling.
AID1346953Human 5-HT4 receptor (5-Hydroxytryptamine receptors)2000British journal of pharmacology, Oct, Volume: 131, Issue:4
Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells.
AID1346953Human 5-HT4 receptor (5-Hydroxytryptamine receptors)2000British journal of pharmacology, Jun, Volume: 130, Issue:3
Exploration of the ligand binding site of the human 5-HT(4) receptor by site-directed mutagenesis and molecular modeling.
AID624238Antagonists at Human 5-Hydroxytryptamine receptor 5-HT42004British journal of pharmacology, Nov, Volume: 143, Issue:5
The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo.
AID1346953Human 5-HT4 receptor (5-Hydroxytryptamine receptors)1998Journal of neurochemistry, Jun, Volume: 70, Issue:6
Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus.
AID1346953Human 5-HT4 receptor (5-Hydroxytryptamine receptors)2004British journal of pharmacology, Nov, Volume: 143, Issue:5
The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo.
AID624238Antagonists at Human 5-Hydroxytryptamine receptor 5-HT42000British journal of pharmacology, Feb, Volume: 129, Issue:4
Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines.
AID6239Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand1997Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.
AID5880Binding affinity was measured on 5-hydroxytryptamine 3 receptor using [3H]-BRL 43694 as radioligand in rat posterior cortex.1997Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.
AID61435-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum; Inactive up to 10E-5 M1997Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.
AID61525-hydroxytryptamine 4 receptor antagonist activity, concentration which gave 50% reduction of the 5-HT-induced contractions in the guinea pig ileum1997Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's4 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.24 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.18 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]