Compounds > brl 24924

Page last updated: 2024-11-10

brl 24924

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	3086547
SCHEMBL ID	678616
MeSH ID	M0150279

Synonyms (10)

Synonym
4-amino-n-[(5s,6s)-1-azabicyclo[3.3.1]nonan-6-yl]-5-chloro-2-methoxybenzamide
gtpl244
4-amino-n-[(4s,5s)-1-azabicyclo[3.3.1]nonan-4-yl]-5-chloro-2-methoxybenzamide
brl 24924
AKOS015909829
SCHEMBL678616
MS-24814
(s)-renzapride
CS-0628485
HY-14147A

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (18)

Assay ID	Title	Year	Journal	Article
AID624236	Agonists at Human 5-Hydroxytryptamine receptor 5-HT4	1995	The EMBO journal, Jun-15, Volume: 14, Issue:12	The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants.
AID624239	Agonists at Rat 5-Hydroxytryptamine receptor 5-HT4
AID624236	Agonists at Human 5-Hydroxytryptamine receptor 5-HT4	1997	Neuroreport, Oct-20, Volume: 8, Issue:15	Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase.
AID624236	Agonists at Human 5-Hydroxytryptamine receptor 5-HT4	2001	Naunyn-Schmiedeberg's archives of pharmacology, Feb, Volume: 363, Issue:2	5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle.
AID1346956	Rat 5-HT4 receptor (5-Hydroxytryptamine receptors)	1996	European journal of pharmacology, May-23, Volume: 304, Issue:1-3	[3H]5-hydroxytryptamine labels the agonist high affinity state of the cloned rat 5-HT4 receptor.
AID624236	Agonists at Human 5-Hydroxytryptamine receptor 5-HT4	1998	Journal of neurochemistry, Jun, Volume: 70, Issue:6	Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus.
AID1346956	Rat 5-HT4 receptor (5-Hydroxytryptamine receptors)
AID1346953	Human 5-HT4 receptor (5-Hydroxytryptamine receptors)	2000	British journal of pharmacology, Feb, Volume: 129, Issue:4	Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines.
AID624237	Agonists at Mouse 5-Hydroxytryptamine receptor 5-HT4	1996	FEBS letters, Nov-25, Volume: 398, Issue:1	Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor.
AID624236	Agonists at Human 5-Hydroxytryptamine receptor 5-HT4	2000	British journal of pharmacology, Oct, Volume: 131, Issue:4	Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells.
AID1346953	Human 5-HT4 receptor (5-Hydroxytryptamine receptors)	2000	British journal of pharmacology, Oct, Volume: 131, Issue:4	Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells.
AID1346953	Human 5-HT4 receptor (5-Hydroxytryptamine receptors)	1995	The EMBO journal, Jun-15, Volume: 14, Issue:12	The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants.
AID1346953	Human 5-HT4 receptor (5-Hydroxytryptamine receptors)	1998	Journal of neurochemistry, Jun, Volume: 70, Issue:6	Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus.
AID1346953	Human 5-HT4 receptor (5-Hydroxytryptamine receptors)	2001	Naunyn-Schmiedeberg's archives of pharmacology, Feb, Volume: 363, Issue:2	5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle.
AID1346938	Mouse 5-HT4 receptor (5-Hydroxytryptamine receptors)	1996	FEBS letters, Nov-25, Volume: 398, Issue:1	Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor.
AID1346953	Human 5-HT4 receptor (5-Hydroxytryptamine receptors)	1997	Neuroreport, Oct-20, Volume: 8, Issue:15	Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase.
AID624236	Agonists at Human 5-Hydroxytryptamine receptor 5-HT4	2000	British journal of pharmacology, Feb, Volume: 129, Issue:4	Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines.
AID624239	Agonists at Rat 5-Hydroxytryptamine receptor 5-HT4	1996	European journal of pharmacology, May-23, Volume: 304, Issue:1-3	[3H]5-hydroxytryptamine labels the agonist high affinity state of the cloned rat 5-HT4 receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (62.50)	18.2507
2000's	3 (37.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.87 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.17 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.87)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
5-methoxytryptamine 5-Methoxytryptamine: Serotonin derivative proposed as potentiator for hypnotics and sedatives.. 5-methoxytryptamine : A member of the class of tryptamines that is the methyl ether derivative of serotonin.	3.38	7	0	aromatic ether; primary amino compound; tryptamines	5-hydroxytryptamine 2A receptor agonist; 5-hydroxytryptamine 2B receptor agonist; 5-hydroxytryptamine 2C receptor agonist; antioxidant; cardioprotective agent; human metabolite; mouse metabolite; neuroprotective agent; radiation protective agent; serotonergic agonist
alpha-methylserotonin alpha-methylserotonin: potent agonist at M & D receptors of serotonin; RN given refers to parent cpd	2.39	2	0	tryptamines	serotonergic agonist
cisapride Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed). cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.	3.25	6	0	benzamides
metoclopramide Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.. metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.	1.99	1	0	benzamides; monochlorobenzenes; substituted aniline; tertiary amino compound	antiemetic; dopaminergic antagonist; environmental contaminant; gastrointestinal drug; xenobiotic
zacopride [no description available]	3.09	5	0	benzamides
gr 113808 GR 113808: structure given in first source; a 5-HT(4) receptor antagonist: GR 125487 is the HCl salt. GR 113808 : An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide.	3.09	5	0	indolyl carboxylate ester; piperidines; sulfonamide	serotonergic antagonist
sb 204070a [no description available]	2.41	2	0
dau 6285 [no description available]	2.39	2	0
sc 53116 SC 53116: serotonin agonist; pyrrolizidine cpd but not alkaloid; structure given in first source	1.99	1	0
piboserod Serotonin 5-HT4 Receptor Antagonists: Drugs that bind to but do not activate SEROTONIN 5-HT4 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN RECEPTOR AGONISTS.	1.99	1	0
rs 23597-190 [no description available]	2.41	2	0	methoxybenzoic acid
rs 67333 RS 67333: 5-HT(4) receptor agonist; structure in first source	2.41	2	0	aromatic ketone
tropisetron Tropisetron: An indole derivative and 5-HT3 RECEPTOR antagonist that is used for the prevention of nausea and vomiting.. tropisetron : An indolyl carboxylate ester obtained by formal condensation of the carboxy group of indole-3-carboxylic acid with the hydroxy group of tropine.	2.69	3	0	indolyl carboxylic acid
sb 203186 [no description available]	2	1	0	indolyl carboxylic acid
gr 125487 [no description available]	2.39	2	0
ml 10302 2-piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate: structure in first source	2.69	3	0
sb 207710 SB 207710: structure given in first source	2	1	0
ml 10375 [no description available]	2.69	3	0

Condition	Indicated	Relationship Strength	Studies	Trials
Glial Cell Tumors [description not available]	0	2	1	0
Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)	0	2	1	0