Compounds > mitoquinol
Page last updated: 2024-11-12

mitoquinol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

mitoquinol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9917765
CHEMBL ID4594414
SCHEMBL ID5565240
MeSH IDM0391356

Synonyms (12)

Synonym
mitoquinol
mitoq10
SCHEMBL5565240
triphenyl(10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl)phosphonium
phosphonium, (10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl)triphenyl-
747398-82-9
65M41NIO61 ,
mitoquinol cation
mitoquinol [who-dd]
unii-65m41nio61
Q27896187
CHEMBL4594414

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" These results suggested that the bioavailability of MitoQ(10) may be limited by intracellular metabolism and the action of P-glycoprotein and BCRP."( Transport and metabolism of MitoQ10, a mitochondria-targeted antioxidant, in Caco-2 cell monolayers.
Fawcett, JP; Li, Y; Tucker, IG; Zhang, H, 2007)		0.34
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's3 (27.27)24.3611
2020's3 (27.27)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index25.41 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.72 (4.65)
Search Engine Demand Index45.13 (26.88)
Search Engine Supply Index3.76 (0.95)

This Compound (25.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (9.09%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		3.711dialdehydebiomarker
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.0710acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
triphenylmethylphosphonium
triphenylmethylphosphonium: RN given refers to parent cpd		2.4420
plastoquinone
[no description available]		2.0710plastoquinone
n-tert-butyl-(2-sulfophenyl)nitrone
N-tert-butyl-(2-sulfophenyl)nitrone: Neuroprotectant		2.0410
mitoquinone
mitoquinone: has antineoplastic activity		5.0691
ubiquinone
Ubiquinone: A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.		5.0591
ConditionIndicatedRelationship StrengthStudiesTrials
Anterior Choroidal Artery Infarction
[description not available]		02.610
Cerebral Ischemia
[description not available]		02.610
Injury, Ischemia-Reperfusion
[description not available]		02.610
Cerebral Infarction
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).		02.610
Brain Ischemia
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.		02.610
Reperfusion Injury
Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.		02.610
Carcinoma, Anaplastic
[description not available]		02.610
Ascites
Accumulation or retention of free fluid within the peritoneal cavity.		02.610
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.610
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.2110
Anoxia-Ischemia, Brain
[description not available]		02.0410
Hypoxia-Ischemia, Brain
A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.		02.0410