Page last updated: 2024-09-28

map4

Description

MAP4: partial amino acid sequence given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1795545
CHEMBL ID1488784
SCHEMBL ID179781
MeSH IDM0189695

Synonyms (21)

Synonym
gtpl1414
NCGC00024744-01
tocris-0711
map4
NCGC00024744-02
(2s)-2-amino-2-methyl-4-phosphonobutanoic acid
AKOS006272533
(s)-2-amino-2-methyl-4-phosphonobutanoic acid
157381-42-5
CHEMBL1488784
SCHEMBL179781
sr-01000597625
SR-01000597625-1
J-009412
4-phosphono-l-isovaline
DTXSID40935660
Q27083516
(s)-map4
l-isovaline, 4-phosphono-
CS-0020934
HY-101164

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Microtubule-associated protein tauHomo sapiens (human)Potency14.12540.180013.557439.8107AID1468
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency39.81070.011212.4002100.0000AID1030
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency35.48130.251215.843239.8107AID504327
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1346255Rat mGlu6 receptor (Metabotropic glutamate receptors)2002Current drug targets. CNS and neurological disorders, Jun, Volume: 1, Issue:3
The metabotropic glutamate receptors: structure, activation mechanism and pharmacology.
AID1346251Rat mGlu8 receptor (Metabotropic glutamate receptors)1997Molecular pharmacology, Jan, Volume: 51, Issue:1
Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile.
AID1346251Rat mGlu8 receptor (Metabotropic glutamate receptors)2000Brain research. Molecular brain research, Mar-10, Volume: 76, Issue:1
Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors.
AID1346283Rat mGlu4 receptor (Metabotropic glutamate receptors)1999The Journal of biological chemistry, Apr-09, Volume: 274, Issue:15
Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor.
AID1346263Human mGlu7 receptor (Metabotropic glutamate receptors)2000Naunyn-Schmiedeberg's archives of pharmacology, Dec, Volume: 362, Issue:6
Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (28.57)18.2507
2000's3 (42.86)29.6817
2010's0 (0.00)24.3611
2020's2 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]