leoligin: inhibits intimal hyperplasia of venous bypass grafts; isolated from Edelweiss; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Leoligin is a natural lignan found in Edelweiss.
| Excerpt | Reference |
|---|---|
| "Leoligin is a natural lignan found in Edelweiss (Leontopodium nivale ssp. " | ( Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages. Atanasov, AG; Dirsch, VM; Heiss, EH; Hošek, J; Ladurner, A; Latkolik, S; Linder, T; Mihovilovic, MD; Palme, V; Polanský, O; Schilcher, N; Schwaiger, S; Stangl, H; Stuppner, H; Wang, L, 2016) |
In vivo, there was also a higher CETP activity after oral dosage of CETP transgenic mice with leoligin (p=0.5)
| Excerpt | Reference |
|---|---|
| " Furthermore, we dosed CETP transgenic mice with leoligin and vehicle control by oral gavage for 7 days and measured subsequently the in vivo modulation of CETP activity (n=5 for each treatment group)." | ( Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein. Bernhard, D; Duwensee, K; Eller, K; Eller, P; Linder, T; Markt, P; Patsch, JR; Ritsch, A; Schuster, D; Schwaiger, S; Stanzl, U; Stuppner, H; Tancevski, I; van Eck, M, 2011) |
| " In vivo, there was also a higher CETP activity after oral dosage of CETP transgenic mice with leoligin (p=0." | ( Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein. Bernhard, D; Duwensee, K; Eller, K; Eller, P; Linder, T; Markt, P; Patsch, JR; Ritsch, A; Schuster, D; Schwaiger, S; Stanzl, U; Stuppner, H; Tancevski, I; van Eck, M, 2011) |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (12.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (87.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||