hectochlorin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

hectochlorin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	636718
CHEMBL ID	505302
SCHEMBL ID	2830174
MeSH ID	M0424697

Synonyms (7)

Synonym
hectochlorin
CHEMBL505302
SCHEMBL2830174
CCG-257498
Q15411003
[(5s,12s,13s,16s)-12-(4,4-dichloropentyl)-16-(2-hydroxypropan-2-yl)-4,4,13-trimethyl-2,10,14-trioxo-3,11,15-trioxa-7,18-dithia-20,21-diazatricyclo[15.2.1.16,9]henicosa-1(19),6(21),8,17(20)-tetraen-5-yl] acetate
DTXSID101045509

Research Excerpts

Overview

Hectochlorin (1) is a marine natural product with significant fungicidal activity.

Excerpt	Reference	Relevance
"Hectochlorin (1) is a marine natural product with significant fungicidal activity. "	( Total synthesis of hectochlorin. Cetusic, JR; Graupner, PR; Green, FR; Oliver, MP, 2002)	2.09

Effects

Excerpt	Reference	Relevance
"Hectochlorin has remarkable antifungal and cytotoxic properties."	( Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula. Gerwick, WH; Ramaswamy, AV; Sorrels, CM, 2007)	1.32

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (27)

Assay ID	Title	Year	Journal	Article
AID335479	Effect on microtubule cytoskeleton in human CA46 cells	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335221	Antimicrobial activity against Candida albicans ATCC 14053 at 10 ug/disk by standard paper sensitivity disk-agar plate method	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335484	Effect on actin cytoskeleton in rat kangaroo PtK2 cells assessed as thickening in microfilament at 1.0 uM after 24 hrs by immunofluorescence analysis relative to untreated control	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335224	Antimicrobial activity against Salmonella choleraesuis subsp. choleraesuis ATCC 14028 by standard paper sensitivity disk-agar plate method	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335486	Effect on actin cytoskeleton in rat kangaroo PtK2 cells assessed as hairy appearance at 3 uM after 24 hrs by immunofluorescence analysis	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335487	Effect on actin cytoskeleton in rat kangaroo PtK2 cells assessed as hairy appearance at 10 uM after 24 hrs by immunofluorescence analysis	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335489	Stimulation of rabbit muscle actin polymerization by centrifugation assay	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335492	Displacement of FITC-phalloidin from rabbit muscle actin polymer after 1 hr by fluorescence analysis	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335223	Antimicrobial activity against Escherichia coli ATCC 1775 by standard paper sensitivity disk-agar plate method	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335493	Displacement of FITC-phalloidin from rabbit muscle actin polymer pretreated prior to FITC-phalloidin addition by fluorescence analysis	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID402349	Cytotoxicity against human KB cells by SRB assay	2005	Journal of natural products, Jun, Volume: 68, Issue:6	Hectochlorin and morpholine derivatives from the Thai sea hare, Bursatella leachii.
AID335490	Stimulation of rabbit muscle actin polymerization assessed as light scattering at 10 to 50 uM by fluorimetry	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335482	Effect on actin cytoskeleton in rat kangaroo PtK2 cells assessed as increase in binucleated cells at 1 to 10 uM after 24 hrs by by immunofluorescence analysis	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335478	Effect on purified tubulin polymerization in human CA46 cells	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335483	Effect on actin cytoskeleton in rat kangaroo PtK2 cells assessed as thickening in microfilament at 0.3 uM after 24 hrs by immunofluorescence analysis relative to untreated control	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335222	Antimicrobial activity against Pseudomonas aeruginosa ATCC 10145 by standard paper sensitivity disk-agar plate method	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335481	Effect on actin cytoskeleton in rat kangaroo PtK2 cells assessed as increase in binucleated cells at 0.3 to 3 uM after 24 hrs by immunofluorescence analysis	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335494	Antiproliferative activity against human NCI60 cells	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335476	Cell cycle arrest in human CA46 cells assessed as accumulation at G2/M phase at 0.2 uM after 24 hrs using propidium iodide labeling by flow cytometry	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335218	Antiproliferative activity against human CA46 cells after 24 hrs	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335480	Ratio of IC50 for rat kangaroo Ptk2 cells to IC50 for human CA46 cells	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335226	Antimicrobial activity against Staphylococcus aureus ATCC 12600 by standard paper sensitivity disk-agar plate method	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335225	Antimicrobial activity against Bacillus subtilis ATCC 6051 by standard paper sensitivity disk-agar plate method	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335220	Antimicrobial activity against Candida albicans ATCC 14053 at 100 ug/disk by standard paper sensitivity disk-agar plate method	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID402350	Cytotoxicity against human NCI-H187 cells by SRB assay	2005	Journal of natural products, Jun, Volume: 68, Issue:6	Hectochlorin and morpholine derivatives from the Thai sea hare, Bursatella leachii.
AID335219	Antiproliferative activity against rat kangaroo PtK2 cells after 48 hrs	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335491	Stimulation of rabbit muscle actin polymerization by electron microscopy	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (57.14)	29.6817
2010's	2 (28.57)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.10

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	20.10 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.55 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (20.10)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
safrole Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).. safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.	2.08	1	benzodioxoles	flavouring agent; insecticide; metabolite; plant metabolite
sulfoxide sulfoxide: synergistic insecticide for use with pyrethrum, allethrin, rotenone, ryania, etc.; RN given refers to parent cpd; structure. sulfoxide : An organosulfur compound having the structure R2S=O or R2C=S=O (R =/= H).	2.08	1	benzodioxoles
thiazoles [no description available]	3.43	7	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
fluorescein-5-isothiocyanate Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.	2.01	1	fluorescein isothiocyanate
lyngbyatoxin a lyngbyatoxin A: indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as swimmers' itch in Hawaii	2.41	1	indoles
apratoxin a apratoxin A: a potent cytotoxin with a novel skeleton, has been isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont; structure in first source. apratoxin A : An aprotoxin having the common aprotoxin cyclodepsipeptide skeleton where the isoleucyl residue carries an N-methyl substituent and the side-chain adjacent to the lactone is tert-butyl.	2.08	1	1,3-thiazoles; apratoxin	antineoplastic agent; metabolite
jasplakinolide jasplakinolide: cyclodepsipeptide isolated from marine sponge Jaspis; active against Candida; RN refers to 2S-(2R,4E,6S,8R*)-isomer; structure in first source. jaspamide : A cyclodepsipeptide isolated from Jaspis splendens and has been shown to exhibit antineoplastic activity. It is an actin polymerization and stabilization inducer.	2.01	1	cyclodepsipeptide; phenols	actin polymerisation inducer; animal metabolite; antifungal agent; antineoplastic agent; apoptosis inducer; marine metabolite; neuroprotective agent
lyngbyabellin a lyngbyabellin A: from the marine cyanobacterium lyngbya majuscula; structure in first source	2.01	1
lyngbyabellin b lyngbyabellin B: from the marine cyanobacterium Lyngbya majuscula; structure in first source	2.44	2

Condition	Relationship Strength	Studies
Hepatocellular Carcinoma [description not available]	2.41	1
Cancer of Liver [description not available]	2.41	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.41	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.41	1

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