Compounds > lyngbyabellin b
Page last updated: 2024-11-13

lyngbyabellin b

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Description

lyngbyabellin B: from the marine cyanobacterium Lyngbya majuscula; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44558912
CHEMBL ID508049
MeSH IDM0374215

Synonyms (2)

Synonym
lyngbyabellin b
CHEMBL508049
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID377906Antimicrobial activity against Salmonella choleraesuis subsp. choleraesuis ATCC 14028 by disk agar plate assay2000Journal of natural products, Oct, Volume: 63, Issue:10
Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula.
AID502766Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay2010Journal of natural products, Sep-24, Volume: 73, Issue:9
Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam.
AID335478Effect on purified tubulin polymerization in human CA46 cells2002Journal of natural products, Jun, Volume: 65, Issue:6
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335489Stimulation of rabbit muscle actin polymerization by centrifugation assay2002Journal of natural products, Jun, Volume: 65, Issue:6
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID377907Antimicrobial activity against Bacillus subtilis ATCC 6051 by disk agar plate assay2000Journal of natural products, Oct, Volume: 63, Issue:10
Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula.
AID335479Effect on microtubule cytoskeleton in human CA46 cells2002Journal of natural products, Jun, Volume: 65, Issue:6
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID377904Antimicrobial activity against Pseudomonas aeruginosa ATCC 10145 by disk agar plate assay2000Journal of natural products, Oct, Volume: 63, Issue:10
Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula.
AID335487Effect on actin cytoskeleton in rat kangaroo PtK2 cells assessed as hairy appearance at 10 uM after 24 hrs by immunofluorescence analysis2002Journal of natural products, Jun, Volume: 65, Issue:6
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335218Antiproliferative activity against human CA46 cells after 24 hrs2002Journal of natural products, Jun, Volume: 65, Issue:6
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID377908Antimicrobial activity against Staphylococcus aureus ATCC 12600 by disk agar plate assay2000Journal of natural products, Oct, Volume: 63, Issue:10
Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula.
AID377901Toxicity against brine shrimp after 24 hrs2000Journal of natural products, Oct, Volume: 63, Issue:10
Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula.
AID335484Effect on actin cytoskeleton in rat kangaroo PtK2 cells assessed as thickening in microfilament at 1.0 uM after 24 hrs by immunofluorescence analysis relative to untreated control2002Journal of natural products, Jun, Volume: 65, Issue:6
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335477Cell cycle arrest in human CA46 cells assessed as accumulation at G2/M phase at 1.0 uM after 24 hrs using propidium iodide labeling by flow cytometry2002Journal of natural products, Jun, Volume: 65, Issue:6
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID502767Cytotoxicity against human HeLa cells after 48 hrs by MTT assay2010Journal of natural products, Sep-24, Volume: 73, Issue:9
Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam.
AID377902Antimicrobial activity against Candida albicans ATCC 14053 at 100 ug/disk by disk agar plate assay2000Journal of natural products, Oct, Volume: 63, Issue:10
Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula.
AID335481Effect on actin cytoskeleton in rat kangaroo PtK2 cells assessed as increase in binucleated cells at 0.3 to 3 uM after 24 hrs by immunofluorescence analysis2002Journal of natural products, Jun, Volume: 65, Issue:6
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID377900Cytotoxicity against human LoVo cells2000Journal of natural products, Oct, Volume: 63, Issue:10
Isolation and structure of the cytotoxin lyngbyabellin B and absolute configuration of lyngbyapeptin A from the marine cyanobacterium Lyngbya majuscula.
AID335219Antiproliferative activity against rat kangaroo PtK2 cells after 48 hrs2002Journal of natural products, Jun, Volume: 65, Issue:6
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID377899Cytotoxicity against human KB cells2000Journal of natural products, Oct, Volume: 63, Issue:10
Isolation and structure of the cytotoxin lyngbyabellin B and absolute configuration of lyngbyapeptin A from the marine cyanobacterium Lyngbya majuscula.
AID377905Antimicrobial activity against sEscherichia coli ATCC 11775 by disk agar plate assay2000Journal of natural products, Oct, Volume: 63, Issue:10
Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula.
AID377903Antimicrobial activity against Candida albicans ATCC 14053 at 10 ug/disk by disk agar plate assay2000Journal of natural products, Oct, Volume: 63, Issue:10
Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula.
AID335482Effect on actin cytoskeleton in rat kangaroo PtK2 cells assessed as increase in binucleated cells at 1 to 10 uM after 24 hrs by by immunofluorescence analysis2002Journal of natural products, Jun, Volume: 65, Issue:6
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335483Effect on actin cytoskeleton in rat kangaroo PtK2 cells assessed as thickening in microfilament at 0.3 uM after 24 hrs by immunofluorescence analysis relative to untreated control2002Journal of natural products, Jun, Volume: 65, Issue:6
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
AID335486Effect on actin cytoskeleton in rat kangaroo PtK2 cells assessed as hairy appearance at 3 uM after 24 hrs by immunofluorescence analysis2002Journal of natural products, Jun, Volume: 65, Issue:6
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.58

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.58 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.37 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.58)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
safrole
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).. safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.		2.0810benzodioxolesflavouring agent;
insecticide;
metabolite;
plant metabolite
sulfoxide
sulfoxide: synergistic insecticide for use with pyrethrum, allethrin, rotenone, ryania, etc.; RN given refers to parent cpd; structure. sulfoxide : An organosulfur compound having the structure R2S=O or R2C=S=O (R =/= H).		2.0810benzodioxoles
thiazoles
[no description available]		2.93401,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
fluorescein-5-isothiocyanate
Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.		2.0110fluorescein isothiocyanate
hectochlorin
hectochlorin: structure in first source		2.4420
apratoxin a
apratoxin A: a potent cytotoxin with a novel skeleton, has been isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont; structure in first source. apratoxin A : An aprotoxin having the common aprotoxin cyclodepsipeptide skeleton where the isoleucyl residue carries an N-methyl substituent and the side-chain adjacent to the lactone is tert-butyl.		2.08101,3-thiazoles;
apratoxin		antineoplastic agent;
metabolite
jasplakinolide
jasplakinolide: cyclodepsipeptide isolated from marine sponge Jaspis; active against Candida; RN refers to 2S-(2R*,4E,6S*,8R*)-isomer; structure in first source. jaspamide : A cyclodepsipeptide isolated from Jaspis splendens and has been shown to exhibit antineoplastic activity. It is an actin polymerization and stabilization inducer.		2.0110cyclodepsipeptide;
phenols		actin polymerisation inducer;
animal metabolite;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
marine metabolite;
neuroprotective agent
lyngbyabellin a
lyngbyabellin A: from the marine cyanobacterium lyngbya majuscula; structure in first source		2.7130
ConditionIndicatedRelationship StrengthStudiesTrials