Compounds > gigantecin
Page last updated: 2024-11-07

gigantecin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

gigantecin: structure given in first source; isolated from the stem bark of Goniothalamus gigateus; a tetrahydroxy-di-tetrahydrofuran fatty acid gamma-lactone (acetogenin) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10371925
CHEMBL ID448180
MeSH IDM0177412

Synonyms (3)

Synonym
gigantecin
CHEMBL448180
(2s)-4-[(2r)-7-[(2r,5s)-5-[(1s,4r)-1,4-dihydroxy-4-[(2r,5r)-5-[(1r)-1-hydroxytridecyl]oxolan-2-yl]butyl]oxolan-2-yl]-2-hydroxyheptyl]-2-methyl-2h-furan-5-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID335309Antimitotic activity in rat 9ASK cells assessed as reversal of astrocyte formation at 10 ug/mL
AID335293Toxicity against brine shrimp
AID335292Antitumor activity assessed as inhibition of Agrobacterium tumefaciens-induced tumor formation by potato disk assay
AID335286Cytotoxicity against human HT-29 cells
AID335289Cytotoxicity against human A549 cells
AID334004Cytotoxicity against human MCF7 cells after 7 days by MTT assay1997Journal of natural products, Sep, Volume: 60, Issue:9
(2,4-cis and trans)-gigantecinone and 4-deoxygigantecin, bioactive nonadjacent bis-tetrahydrofuran annonaceous acetogenins, from Goniothalamus giganteus.
AID334001Toxicity to brine shrimp1997Journal of natural products, Sep, Volume: 60, Issue:9
(2,4-cis and trans)-gigantecinone and 4-deoxygigantecin, bioactive nonadjacent bis-tetrahydrofuran annonaceous acetogenins, from Goniothalamus giganteus.
AID335288Cytotoxicity against human 9KB cells
AID335290Cytotoxicity against mouse 9PS cells
AID335280Cytotoxicity against human MCF7 cells
AID334003Cytotoxicity against human A549 cells after 7 days by MTT assay1997Journal of natural products, Sep, Volume: 60, Issue:9
(2,4-cis and trans)-gigantecinone and 4-deoxygigantecin, bioactive nonadjacent bis-tetrahydrofuran annonaceous acetogenins, from Goniothalamus giganteus.
AID334002Insecticidal activity against yellow fever mosquito larvae by microtiter plate assay1997Journal of natural products, Sep, Volume: 60, Issue:9
(2,4-cis and trans)-gigantecinone and 4-deoxygigantecin, bioactive nonadjacent bis-tetrahydrofuran annonaceous acetogenins, from Goniothalamus giganteus.
AID334005Cytotoxicity against human HT29 cells after 7 days by MTT assay1997Journal of natural products, Sep, Volume: 60, Issue:9
(2,4-cis and trans)-gigantecinone and 4-deoxygigantecin, bioactive nonadjacent bis-tetrahydrofuran annonaceous acetogenins, from Goniothalamus giganteus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
malonic acid
malonic acid : An alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.. dicarboxylic acid : Any carboxylic acid containing two carboxy groups.		2.0610alpha,omega-dicarboxylic acidhuman metabolite
rotenone
Derris: A plant genus of the family FABACEAE. The root is a source of rotenoids (ROTENONE) and flavonoids. Some species of Pongamia have been reclassified to this genus and some to MILLETTIA. Some species of Deguelia have been reclassified to this genus.. rotenoid : Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.		1.9910organic heteropentacyclic compound;
rotenones		antineoplastic agent;
metabolite;
mitochondrial NADH:ubiquinone reductase inhibitor;
phytogenic insecticide;
piscicide;
toxin
tetrahydrofuran
oxolane : A cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen.		6.9710cyclic ether;
oxolanes;
saturated organic heteromonocyclic parent;
volatile organic compound		polar aprotic solvent
ruthenium
Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.		2.0610iron group element atom;
platinum group metal atom
alkenes
[no description available]		2.0310
oxazolidin-2-one
Oxazolidinones: Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.. oxazolidin-2-one : An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.. oxazolidinone : An oxazolidine containing one or more oxo groups.		2.0210carbamate ester;
oxazolidinone		metabolite
ConditionIndicatedRelationship StrengthStudiesTrials