| ID Source | ID |
|---|---|
| PubMed CID | 156406 |
| SCHEMBL ID | 2186436 |
| MeSH ID | M0221706 |
| Synonym |
|---|
| florfenicol amine |
| (1r,2s)-2-amino-3-fluoro-1-(4-methylsulfonylphenyl)propan-1-ol |
| sch-40458 |
| 76639-93-5 |
| benzenemethanol, alpha-(1-amino-2-fluoroethyl)-4-(methylsulfonyl)-, (r-(r*,s*))- |
| AKOS017343690 |
| (1r,2s)-1-[4-(methylsulfonyl)phenyl]-2-amino-3-fluoro-1-propanol |
| XLSYLQDVLAXIKK-NXEZZACHSA-N |
| (1r,2 s)-2-amino-3-fluoro-1-(4-methylsulfonylphenyl)-1-propanol |
| (1r,2s)-2-amino-3-fluoro-1-(4-methylsulfonylphenyl)-1-propanol |
| DTXSID30227460 |
| SCHEMBL2186436 |
| (1r,2s)-2-amino-3-fluoro-1-[4-methanesulfonyl)phenyl]-1-propanol |
| mfcd19704818 |
| florfenicol amine, vetranal(tm), analytical standard |
| benzenemethanol, ?-(1-amino-2-fluoroethyl)-4-(methylsulfonyl)-, [r-(r*,s*)]-; (?r)-?-[(1s)-1-amino-2-fluoroethyl]-4-(methylsulfonyl)benzenemethanol; (1r,2s)-2-amino-3-fluoro-1-[4-methanesulfonyl)phenyl]-1-propanol; florfenicol amine; sch 40458 |
| florfenicol-amine |
| rel-(1r,2s)-2-amino-3-fluoro-1-(4-(methylsulfonyl)phenyl)propan-1-ol |
| 105182-37-4 |
| HY-133695 |
| CS-0129356 |
| E87790 |
| (alphar)-alpha-[(1s)-1-amino-2-fluoroethyl]-4-(methylsulfonyl)benzenemethanol |
| (1r,2s)-2-amino-3-fluoro-1-(4-(methylsulfonyl)phenyl)propan-1-ol |
| Excerpt | Reference | Relevance |
|---|---|---|
| " florfenicol injection (as a bolus), the terminal half-life (t(1/2)), the volume of distribution at steady state (V(dss)), and total body clearance were 11." | ( Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus). Kim, MS; Lim, JH; Park, BK; Yun, HI, 2006) | 0.58 |
| " The maximum concentrations (Cmax , μg g(-1) or μg mL(-1) ) in plasma and tissues were observed at 2-6 h (the time to reach maximum concentration, Tmax ) except for bile (Tmax = 24 h) and were in the order of intestine (52." | ( Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange-spotted grouper (Epinephelus coioides) after oral administration. Dong, JD; Feng, JB; Huang, DR; Liu, P; Zhong, M, 2016) | 0.67 |
| " This study aimed to develop a population physiologically based pharmacokinetic (PBPK) model to predict the concentrations of FF and its metabolite, florfenicol amine (FFA), in cattle after four different routes of administration, and to calculate and compare the withdrawal intervals (WDIs) with approved withdrawal times based on different marker residues and their MRLs or tolerances." | ( Development and application of a population physiologically based pharmacokinetic model for florfenicol and its metabolite florfenicol amine in cattle. Baynes, RE; Lin, Z; Riviere, JE; Yang, F, 2019) | 0.92 |
| " Pharmacokinetic parameters were calculated using non-compartmental analysis." | ( Pharmacokinetics, tissue residue depletion, and withdrawal interval estimations of florfenicol in goats following repeated subcutaneous administrations. Chen, Q; Clapham, MO; Davis, JL; Lin, Z; Tell, LA; Toney, E; Wetzlich, SE; Wu, X, 2023) | 0.91 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " administration of florfenicol, the t(1/2), C(max), t(max) and oral bioavailability (F) were 15." | ( Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus). Kim, MS; Lim, JH; Park, BK; Yun, HI, 2006) | 0.58 |
| "A study on the bioavailability and pharmacokinetics of florfenicol was conducted in six healthy dogs following a single intravenous (i." | ( Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in dogs. Hwang, YH; Kim, MS; Lim, JH; Park, BK; Yun, HI, 2008) | 0.6 |
| " Oral bioavailability was found to be 87 +/- 16%." | ( Plasma and tissue depletion of florfenicol and florfenicol-amine in chickens. Anadón, A; Ares, I; Caballero, V; Martínez, M; Martínez, MA; Martínez-Larrañaga, MR; Ríos, A, 2008) | 0.35 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to evaluate the depletion of florfenicol and its major metabolite, florfenicol amine, from the edible tissue of two fish species, rainbow trout and sea bream, following treatment with medicated feed at a dosage of 10 mg kg(-1) of bw day(-1) , for 10 consecutive days." | ( Florfenicol depletion in edible tissue of rainbow trout, Oncorhynchus mykiss (Walbaum), and sea bream, Sparus aurata L. della Rocca, G; Di Salvo, A; Malvisi, J; Terzetti, E, 2013) | 0.61 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.63) | 18.2507 |
| 2000's | 8 (21.05) | 29.6817 |
| 2010's | 22 (57.89) | 24.3611 |
| 2020's | 7 (18.42) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (23.32) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 3 (6.82%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 41 (93.18%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||