Compounds > e-4868
Page last updated: 2024-12-06

e-4868

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Description

E-4868: has activity against gram-negative & some gram-positive bacteria; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID65995
CHEMBL ID132468
SCHEMBL ID1230055
MeSH IDM0216488

Synonyms (18)

Synonym
cetefloxacin
CHEMBL132468
7-[(2s,3r)-3-amino-2-methylazetidin-1-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxoquinoline-3-carboxylic acid
e-4868
unii-cfy01mzd5t
3-quinolinecarboxylic acid, 7-(3-amino-2-methyl-1-azetidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, (2s-trans)-
cetefloxacin [inn]
141725-88-4
cfy01mzd5t ,
(-)-7-((2s,3r)-3-amino-2-methyl-1-azetidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
e 4868
7-(3-amino-2-methyl-1-azetidinyl)-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-3-quinolinecarboxylic acid
SCHEMBL1230055
DTXSID30161810
e4868
compound 43f [pmid: 7990118]
gtpl10790
Q27275440
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (34)

Assay IDTitleYearJournalArticle
AID96426In vitro minimum inhibitory concentration to inhibit Klebsiella pneumoniae ATCC 100311994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID163395In vitro minimum inhibitory concentration for Proteus vulgaris ATCC 84271994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID209229In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Streptococcus faecalis ATCC 10541 (Sf).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID125265In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on morganella morganii ATCC 8019 (Mm).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID205883In vitro minimum inhibitory concentration for Staphylococcus epidermidis ATCC 155-11994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID163249In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on proteus vulgaris ATCC 8427 (Pv).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID21978Solubility (buffer pH 7.4)1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID165193In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Pseudomonas aeruginosa ATCC 10145 (Pa).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID95535In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on klebsiella pneumoniae ATCC 10031 (Kp).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID207363In vitro minimum inhibitory concentration for Staphylococcus aureus ATCC 251781994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID162785In vitro minimum inhibitory concentration for Pseudomonas aeruginosa ATCC 101451994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID10953AUC in mice after oral dose (50 mg/kg)1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID206614In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Staphylococcus aureus ATCC 25178 (Sa).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID112205Evaluation of efficacy on systemic infections Staphylococcus aureus HS-93, after oral administration in mice1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID21530Solubility in water was determined at 25 degrees Centigrade1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID23950HPLC capacity factor (k')1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID10955AUC (0-4 hr) ug/ml/h1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID113507In vivo efficacy as ED50 against Staphylococcus aureus HS-93 by oral administration in mice.1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID40781In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Bacillus subtilis ATCC 6633(Bs).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID125408In vitro minimum inhibitory concentration for Morganella morganii ATCC 80191994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID112204Evaluation of efficacy on systemic infections Pseudomonas aeruginosa HS-116, after oral administration in mice1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID205747In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Staphylococcus epidermidis ATCC 155-1 (Se).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID68208In vitro antibacterial activity measured as minimum inhibitory concentration, was evaluated on Enterobacter cloacae ATCC 23355 (Ecl).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID40323In vitro minimum inhibitory concentration for Bacillus cereus ATCC 117781994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID21334Solubility at pH 7.4 buffer.1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID209238In vitro minimum inhibitory concentration for Streptococcus faecalis ATCC 105411994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID113506In vivo efficacy as ED50 against Pseudomonas aeruginosa HS-116 by oral administration in mice.1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID68864In vitro minimum inhibitory concentration for Escherichia coli ATCC 107991994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID112203Evaluation of efficacy on systemic infections Escherichia coli HM-42, after oral administration in mice1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID71098In vitro antibacterial activity measured as minimum inhibitory concentration, was evaluated on Escherichia coli ATCC 23559(Ec).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID40785In vitro minimum inhibitory concentration for Bacillus subtilis ATCC 66331994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID113378In vivo efficacy as ED50 against Escherichia coli HM-42 by oral administration in mice.1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID68371In vitro minimum inhibitory concentration for Enterobacter cloacae ATCC 233551994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID40320In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Bacillus cereus ATCC 11778 (Bc).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 42.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index42.87 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index60.55 (26.88)
Search Engine Supply Index2.08 (0.95)

This Compound (42.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		8.0850aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
fleroxacin
Fleroxacin: A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.. fleroxacin : A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.		7.3920difluorobenzene;
fluoroquinolone antibiotic;
monocarboxylic acid;
N-alkylpiperazine;
quinolines		antibacterial drug;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor
ofloxacin
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.. 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.. ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.		7.67303-oxo monocarboxylic acid;
N-arylpiperazine;
N-methylpiperazine;
organofluorine compound;
oxazinoquinoline
carbostyril
Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.		3.0850monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
clinafloxacin
clinafloxacin: structure given in first source; RN given is for monoHCl		1.9810quinolines
sparfloxacin
[no description available]		1.9810fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone
grepafloxacin
grepafloxacin: structure in first source		1.9810fluoroquinolone antibiotic;
quinolines;
quinolone antibiotic
bay y3118
Bay Y3118: structure given in first source		1.9810
e 4695
E 4695: structure given in first source		2.3920
levofloxacin
Levofloxacin: The L-isomer of Ofloxacin.. levofloxacin : An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.		1.98109-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;
fluoroquinolone antibiotic;
quinolone antibiotic		antibacterial drug;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
E coli Infections
[description not available]		01.9810
Infections, Pseudomonas
[description not available]		01.9810
Infections, Staphylococcal
[description not available]		01.9810
Escherichia coli Infections
Infections with bacteria of the species ESCHERICHIA COLI.		01.9810
Pseudomonas Infections
Infections with bacteria of the genus PSEUDOMONAS.		01.9810
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		01.9810
Bacterial Disease
[description not available]		01.9810
Bacterial Infections
Infections by bacteria, general or unspecified.		01.9810