clematichinenoside-ar and Colitis

Clematichinenoside AR (AR) is a saponin extracted for traditional Chinese medicine with the effects of improving the expression of tight junction (TJ) proteins and mediating anti-inflammatory activities. However, its effect on Crohn's disease (CD) is still unknown. We aimed to investigate the impact of AR on CD-like colitis and determine the mechanism underlying its effects.. AR may have therapeutic potential for treating CD in humans.

Topics: Animals; Bacterial Translocation; Colitis; Cytokines; Interleukin-10; Intestines; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Saponins; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Triterpenes