Page last updated: 2024-12-06

bicarphene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

bicarphene: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	42553
CHEMBL ID	2105505
SCHEMBL ID	1813871
SCHEMBL ID	11761803
MeSH ID	M0069397

Synonyms (35)

Synonym
benzhydrol, 2,2'-dimethyl-alpha-(3-quinuclidinyl)-
sequifenadina [spanish]
sequifenadine [inn]
bicarphene
3-quinuclidinemethanol, alpha,alpha-di-o-tolyl-
sequifenadine
brn 1548429
sequifenadinum [latin]
alpha,alpha-di-o-tolyl-3-quinuclidinemethanol
STL026230
1-azabicyclo[2.2.2]oct-3-yl[bis(2-methylphenyl)]methanol
1-azabicyclo[2.2.2]octan-3-yl-bis(2-methylphenyl)methanol
1-azabicyclo[2.2.2]oct-3-yl[bis(2-methylphenyl)]methanol hydrochloride
sequifenadinum
57734-69-7
sequifenadina
c7q3tbr3fp ,
unii-c7q3tbr3fp
CHEMBL2105505
AKOS005174257
D10510
AB01321356-02
sequifenadine [who-dd]
sequifenadine [mart.]
SCHEMBL1813871
SCHEMBL11761803
SR-01000944892-1
sr-01000944892
Q4418107
DB13566
NCGC00326051-01
(1-azabicyclo[2.2.2]octan-3-yl)bis(2-methylphenyl)methanol
DTXSID40866647
CS-0326942
HY-W281862

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (62.50)	18.7374
1990's	3 (37.50)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	2 (18.18%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	2 (18.18%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (63.64%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
dinitrochlorobenzene Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.. 1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.	1.96	1	0	C-nitro compound; monochlorobenzenes	allergen; epitope; sensitiser
diphenhydramine Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.. diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.. antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.	1.96	1	0	ether; tertiary amino compound	anti-allergic agent; antidyskinesia agent; antiemetic; antiparkinson drug; antipruritic drug; antitussive; H1-receptor antagonist; local anaesthetic; muscarinic antagonist; oneirogen; sedative
quinuclidines Quinuclidines: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms and contains an amine group.	5.42	8	2	quinuclidines; saturated organic heterobicyclic parent
prospidium Prospidium: An antineoplastic dispiropiperazine derivative.	2.38	2	0
quifenadine quifenadine: Russian drug	1.96	1	0	diarylmethane

Condition	Indicated	Relationship Strength	Studies	Trials
Delayed Hypersensitivity [description not available]	0	3.75	2	1
Allergic Reaction [description not available]	0	1.96	1	0
Dermatoses [description not available]	0	1.96	1	0
Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	1	3.96	1	0
Skin Diseases Diseases involving the DERMIS or EPIDERMIS.	0	1.96	1	0
Itching [description not available]	0	1.96	1	0
Lichen Simplex Chronicus [description not available]	0	1.96	1	0
Neurodermatitis An extremely variable eczematous skin disease that is presumed to be a response to prolonged vigorous scratching, rubbing, or pinching to relieve intense pruritus. It varies in intensity, severity, course, and morphologic expression in different individuals. Neurodermatitis is believed by some to be psychogenic. The circumscribed or localized form is often referred to as lichen simplex chronicus.	0	1.96	1	0
Pruritus An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.	0	1.96	1	0
Allergic Conjunctivitis [description not available]	0	3.36	1	1
Hay Fever [description not available]	0	3.36	1	1
Rhinitis, Allergic, Nonseasonal [description not available]	0	3.36	1	1
Conjunctivitis, Allergic Conjunctivitis due to hypersensitivity to various allergens.	0	3.36	1	1
Rhinitis, Allergic, Seasonal Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.	0	3.36	1	1
Rhinitis, Allergic, Perennial Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.	0	3.36	1	1
Chronic Illness [description not available]	0	1.97	1	0
Mast Cell Activation Disease [description not available]	0	2.38	2	0
Spider Veins [description not available]	0	1.97	1	0
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	0	1.97	1	0
Mastocytosis A rare neoplastic disorder characterized by a clonal proliferation of MAST CELLS, associated with KIT-D816 mutations, and accompanied by aberrant mast cell activation. The abnormal increase of MAST CELLS may occur in only the skin (MASTOCYTOSIS, CUTANEOUS), in extracutaneous tissues involving multiple organs (MASTOCYTOSIS, SYSTEMIC), or in solid tumors (MASTOCYTOMA).	0	2.38	2	0
Telangiectasis Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most commonly in the skin or mucous membranes. It is characterized by the prominence of skin blood vessels, such as vascular spiders.	0	1.97	1	0
Eczema, Atopic [description not available]	0	3.76	2	1
Dermatitis, Atopic A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.	0	3.76	2	1
Atopic Hypersensitivity [description not available]	0	3.35	1	1

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