| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID630024 | Inhibition of CYP3A4 | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630011 | Displacement of [3H]PGD2 from human CRTH2 receptor | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630034 | Antagonist activity against human CRTh2 receptor in human eosinophils assessed as inhibition of DK-PGD2-induced CD11b expression | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630019 | Intrinsic clearance in rat hepatocytes assessed as per 1 x 10'6 cells | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630027 | Clearance in Sprague-Dawley rat at 1 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630018 | Inhibition of human recombinant aldose reductase 1 after 15 mins by spectrophotometry analysis | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630030 | Oral bioavailability in Sprague-Dawley rat at 4 mg/kg | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630017 | Inhibition of human recombinant aldose reductase 2 after 15 mins by spectrophotometry analysis | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630020 | Intrinsic clearance in human liver microsomes assessed as per mg of tissue | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630026 | Antagonist activity at prostanoid TP receptor assessed as inhibition of arachidonic acid-induced platelet aggregation at >/= 1 uM | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630022 | Inhibition of CYP1A2 | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630023 | Inhibition of CYP2D6 | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630032 | Antagonist activity at prostanoid DP1 receptor | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630025 | Lipophilicity, log D of the compound at pH 7.4 | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630028 | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID705353 | Displacement of [3H]PGD2 from recombinant human CRTH2 expressed in HEK293 cells after 2 hrs by microbeta scintillation counting | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis. |
| AID630029 | Half life in Sprague-Dawley rat at 1 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630021 | Inhibition of CYP2C9 | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID630033 | Inhibition of COX1 assessed as inhibition of arachidonic acid-induced platelet aggregation at >/= 1 uM | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| AID1346326 | Human DP2 receptor (Prostanoid receptors) | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |