Compounds > a 1110u
Page last updated: 2024-12-10

a 1110u

Cross-References

ID SourceID
PubMed CID9554760
CHEMBL ID77927
MeSH IDM0165306

Synonyms (10)

Synonym
CHEMBL77927
carbonothioic dihydrazide, n''-[(dimethylamino)thioxomethyl]-n'''-[(1e)-1-(2-pyridinyl)ethylidene]-
1,1-dimethyl-3-[[(e)-1-(2-pyridyl)ethylideneamino]carbamothioylamino]thiourea
a 1110u
HY-108149
CS-0027440
2acetylpyridinethiocarbonohydrazonenndimethyl
DTXSID60876566
(e)-n,n-dimethyl-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinecarbonothioyl)hydrazinecarbothioamide
AKOS040747637

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" None of the novel ribonucleotide reductase inactivators was hematologically toxic to rats following oral dosing at 60 mg/kg/day for 30 days."( Inactivators of herpes simplex virus ribonucleotide reductase: hematological profiles and in vivo potentiation of the antiviral activity of acyclovir.
Blumenkopf, TA; Ellis, MN; Lobe, DC; Spector, T; Szczech, GM, 1992)		0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID198116Inactivation of HSV-1 ribonucleotide reductase at rate constant K inact1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID198123Inhibitory index against human ribonucleotide reductase1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID29347pKa value of the compound1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID198115Inhibitory index against HSV-1 ribonucleotide reductase1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID28732Partition coefficient (logD5.2) (octanol/pH 5.2 acetate buffer)1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID198122Inhibition of human ribonucleotide reductase1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID227706Apparent enzyme activity measured as the ratio of HSV-1 and human enzyme inhibition induces1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID198124Inactivation of human ribonucleotide reductase at rate constant K inact1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID198114Inhibition of HSV-1 ribonucleotide reductase1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (28.57)18.7374
1990's5 (71.43)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1,10-phenanthroline
1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases		1.9710phenanthrolineEC 2.7.1.1 (hexokinase) inhibitor;
EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor
deferoxamine
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.		1.9710acyclic desferrioxaminebacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore
cytidine diphosphate
Cytidine Diphosphate: Cytidine 5'-(trihydrogen diphosphate). A cytosine nucleotide containing two phosphate groups esterified to the sugar moiety. Synonyms: CRPP; cytidine pyrophosphate.		1.9710cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-diphosphate		Escherichia coli metabolite;
mouse metabolite
ferrous sulfate
ferrous sulfate: Ferro-Gradumet is ferrous sulfate in controlled release form; RN given refers to Fe(+2)[1:1] salt. iron(2+) sulfate (anhydrous) : A compound of iron and sulfate in which the ratio of iron(2+) to sulfate ions is 1:1. Various hydrates occur naturally - most commonly the heptahydrate, which loses water to form the tetrahydrate at 57degreeC and the monohydrate at 65degreeC.		1.9710iron molecular entity;
metal sulfate		reducing agent
1,7-phenanthroline
[no description available]		1.9710phenanthroline
compound 348u87
compound 348U87: structure given in first source; antiherpes cpd		2.3820
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2.89402-aminopurines;
oxopurine		antimetabolite;
antiviral drug
ConditionIndicatedRelationship StrengthStudiesTrials
Herpes Simplex Virus Infection
[description not available]		02.3820
Herpes Simplex
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)		02.3820
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