Page last updated: 2024-12-10

a 1110u

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID9554760
CHEMBL ID77927
MeSH IDM0165306

Synonyms (10)

Synonym
CHEMBL77927
carbonothioic dihydrazide, n''-[(dimethylamino)thioxomethyl]-n'''-[(1e)-1-(2-pyridinyl)ethylidene]-
1,1-dimethyl-3-[[(e)-1-(2-pyridyl)ethylideneamino]carbamothioylamino]thiourea
a 1110u
HY-108149
CS-0027440
2acetylpyridinethiocarbonohydrazonenndimethyl
DTXSID60876566
(e)-n,n-dimethyl-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinecarbonothioyl)hydrazinecarbothioamide
AKOS040747637

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" None of the novel ribonucleotide reductase inactivators was hematologically toxic to rats following oral dosing at 60 mg/kg/day for 30 days."( Inactivators of herpes simplex virus ribonucleotide reductase: hematological profiles and in vivo potentiation of the antiviral activity of acyclovir.
Blumenkopf, TA; Ellis, MN; Lobe, DC; Spector, T; Szczech, GM, 1992
)
0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID198116Inactivation of HSV-1 ribonucleotide reductase at rate constant K inact1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID198123Inhibitory index against human ribonucleotide reductase1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID29347pKa value of the compound1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID198115Inhibitory index against HSV-1 ribonucleotide reductase1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID28732Partition coefficient (logD5.2) (octanol/pH 5.2 acetate buffer)1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID198122Inhibition of human ribonucleotide reductase1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID227706Apparent enzyme activity measured as the ratio of HSV-1 and human enzyme inhibition induces1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID198124Inactivation of human ribonucleotide reductase at rate constant K inact1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
AID198114Inhibition of HSV-1 ribonucleotide reductase1992Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (28.57)18.7374
1990's5 (71.43)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]