Compounds > 8-methoxycaffeine
Page last updated: 2024-12-05

8-methoxycaffeine

8-methoxycaffeine, a synthetic derivative of caffeine, is known for its potent adenosine receptor antagonistic properties. It is synthesized by methylation of theobromine with dimethyl sulfate in the presence of a base. Research interest in 8-methoxycaffeine stems from its potential therapeutic applications. Studies have shown that it exhibits anxiolytic and antidepressant-like effects in animal models, suggesting its potential as a treatment for anxiety and depression. Additionally, 8-methoxycaffeine has been investigated for its cognitive-enhancing effects, particularly in relation to memory and attention. Its potential for improving cognitive function has led to ongoing research exploring its use in treating age-related cognitive decline and neurodegenerative disorders. However, further investigation is required to understand its long-term effects and safety in humans.'

Cross-References

ID SourceID
PubMed CID11286
SCHEMBL ID2386923
MeSH IDM0182809

Synonyms (27)

Synonym
HMS1757C06
einecs 209-312-3
brn 0384756
1h-purine-2,6-dione, 3,7-dihydro-8-methoxy-1,3,7-trimethyl-
8-methoxy-1,3,7-trimethylxanthine
nsc 8808
nsc8808
8-methoxycaffeine
caffeine, 8-methoxy-
569-34-6
1h-purine-2, 3,7-dihydro-8-methoxy-1,3,7-trimethyl-
methoxycaffeine
nsc-8808
8-methoxy-1,3,7-trimethylpurine-2,6-dione
AKOS002528744
5-26-15-00080 (beilstein handbook reference)
3ur74i2980 ,
unii-3ur74i2980
methoxycaffeine, 8-
SCHEMBL2386923
ATPSJRIIRXKPER-UHFFFAOYSA-N
8-methoxy-1,3,7-trimethyl-3,7-dihydro-1h-purine-2,6-dione #
DTXSID20205434
8-methoxy-1,3,7-trimethyl-3,7-dihydro-1h-purine-2,6-dione
Q27258049
STARBLD0008883
Z56919066

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The dose-response curve was bell-shaped for both compounds."( Production of protein-associated DNA breaks by 8-methoxycaffeine, caffeine and 8-chlorocaffeine in isolated nuclei from L1210 cells: comparison with those produced by topoisomerase II inhibitors.
Kohn, KW; Parodi, S; Pedrini, AM; Poggi, L; Pommier, Y; Russo, P, 1991)		0.54
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (66.67)18.2507
2000's0 (0.00)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.43 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.37 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
caffeine
[no description available]		2.8940purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.3820indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Leukemia L 1210
[description not available]		02.3820
Abnormalities, Autosome
[description not available]		01.9710
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