8-methoxycaffeine, a synthetic derivative of caffeine, is known for its potent adenosine receptor antagonistic properties. It is synthesized by methylation of theobromine with dimethyl sulfate in the presence of a base. Research interest in 8-methoxycaffeine stems from its potential therapeutic applications. Studies have shown that it exhibits anxiolytic and antidepressant-like effects in animal models, suggesting its potential as a treatment for anxiety and depression. Additionally, 8-methoxycaffeine has been investigated for its cognitive-enhancing effects, particularly in relation to memory and attention. Its potential for improving cognitive function has led to ongoing research exploring its use in treating age-related cognitive decline and neurodegenerative disorders. However, further investigation is required to understand its long-term effects and safety in humans.'
| ID Source | ID |
|---|---|
| PubMed CID | 11286 |
| SCHEMBL ID | 2386923 |
| MeSH ID | M0182809 |
| Synonym |
|---|
| HMS1757C06 |
| einecs 209-312-3 |
| brn 0384756 |
| 1h-purine-2,6-dione, 3,7-dihydro-8-methoxy-1,3,7-trimethyl- |
| 8-methoxy-1,3,7-trimethylxanthine |
| nsc 8808 |
| nsc8808 |
| 8-methoxycaffeine |
| caffeine, 8-methoxy- |
| 569-34-6 |
| 1h-purine-2, 3,7-dihydro-8-methoxy-1,3,7-trimethyl- |
| methoxycaffeine |
| nsc-8808 |
| 8-methoxy-1,3,7-trimethylpurine-2,6-dione |
| AKOS002528744 |
| 5-26-15-00080 (beilstein handbook reference) |
| 3ur74i2980 , |
| unii-3ur74i2980 |
| methoxycaffeine, 8- |
| SCHEMBL2386923 |
| ATPSJRIIRXKPER-UHFFFAOYSA-N |
| 8-methoxy-1,3,7-trimethyl-3,7-dihydro-1h-purine-2,6-dione # |
| DTXSID20205434 |
| 8-methoxy-1,3,7-trimethyl-3,7-dihydro-1h-purine-2,6-dione |
| Q27258049 |
| STARBLD0008883 |
| Z56919066 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dose-response curve was bell-shaped for both compounds." | ( Production of protein-associated DNA breaks by 8-methoxycaffeine, caffeine and 8-chlorocaffeine in isolated nuclei from L1210 cells: comparison with those produced by topoisomerase II inhibitors. Kohn, KW; Parodi, S; Pedrini, AM; Poggi, L; Pommier, Y; Russo, P, 1991) | 0.54 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.43) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||