8-methoxycaffeine has been researched along with caffeine in 4 studies
*Caffeine: A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling. [MeSH]
*Caffeine: A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andersen, AH; Christiansen, K; Pedrini, AM; Tornaletti, S | 1 |
| Kohn, KW; Parodi, S; Pedrini, AM; Poggi, L; Pommier, Y; Russo, P | 1 |
| Billi, G; Brega, I; Parodi, S; Piccini, D; Poggi, L; Russo, P; Vigani, A; Zignaigo, G | 1 |
| Cimoli, G; De Sessa, F; Parodi, S; Pommier, Y; Russo, P; Valenti, M | 1 |
4 other study(ies) available for 8-methoxycaffeine and caffeine
| Article | Year |
|---|---|
8-methoxycaffeine inhibition of Drosophila DNA topoisomerase II.
Topics: Animals; Binding Sites; Caffeine; Drosophila; Topoisomerase II Inhibitors | 1992 |
Production of protein-associated DNA breaks by 8-methoxycaffeine, caffeine and 8-chlorocaffeine in isolated nuclei from L1210 cells: comparison with those produced by topoisomerase II inhibitors.
Topics: Animals; Autoradiography; Caffeine; Cell Nucleus; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Neoplasm; DNA, Viral; Drug Interactions; Ellipticines; Genes, myc; Humans; Leukemia L1210; Mice; Proto-Oncogene Proteins c-myc; Simian virus 40; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1991 |
8-methoxycaffeine-induced protein-associated DNA breaks in isolated L1210 cell nuclei.
Topics: Animals; Caffeine; Chromosome Aberrations; Cross-Linking Reagents; DNA Damage; Doxorubicin; Ellipticines; Intercalating Agents; Leukemia L1210; Mice; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1990 |
Induction of DNA double-strand breaks by 8-methoxycaffeine: cell cycle dependence and comparison with topoisomerase II inhibitors.
Topics: Caffeine; Cell Cycle; Cell Survival; DNA; DNA Damage; Humans; T-Lymphocytes; Topoisomerase II Inhibitors | 1994 |