Page last updated: 2024-11-11

6-selenoguanine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

6-selenoguanine: analog of 6-thioguanine with superior therapeutic index & lower toxicity; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6337487
CHEMBL ID295864
SCHEMBL ID157322
MeSH IDM0053743

Synonyms (8)

Synonym
2-amino-1,7-dihydro-6h-purine-6-selone
6-selenoguanine
CHEMBL295864
5375-85-9
SCHEMBL157322
AYLMUGUFZHMFIK-UHFFFAOYSA-N
DTXSID00968515
(2-imino-3,9-dihydro-2h-purin-6-yl)selanyl
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID98781Median survival time at a compound dose of 100 mg/kg, in mice bearing L1210 cells on days 1 and 51981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Synthesis of seleno- and thioguanine-platinum(II) complexes and their antitumor activity in mice.
AID98289Ratio of the median survival time (treated(T) versus control(C)) at a dose of 50 mg/kg, on days 1 and 51981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Synthesis of seleno- and thioguanine-platinum(II) complexes and their antitumor activity in mice.
AID233530The number of mice survived to that of total when no compound dose was given on 30th day1981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Synthesis of seleno- and thioguanine-platinum(II) complexes and their antitumor activity in mice.
AID98793Median survival time at a compound dose of 50 mg/kg, in mice bearing L1210 cells on days 1 and 51981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Synthesis of seleno- and thioguanine-platinum(II) complexes and their antitumor activity in mice.
AID96816In vitro inhibitory concentration required for 50% inhibition of L1210 cell growth1981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Synthesis of seleno- and thioguanine-platinum(II) complexes and their antitumor activity in mice.
AID230171The number of mice survived to that of total at a dose of 100 mg/kg on 30th day; 3/51981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Synthesis of seleno- and thioguanine-platinum(II) complexes and their antitumor activity in mice.
AID97793Effect dose of 50 mg/kg on day 3, before L1210 cell transplantation in mice1981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Synthesis of seleno- and thioguanine-platinum(II) complexes and their antitumor activity in mice.
AID98278Ratio of the median survival time (treated(T) versus control(C)) at a dose of 100 mg/kg, on days 1 and 51981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Synthesis of seleno- and thioguanine-platinum(II) complexes and their antitumor activity in mice.
AID98787Median survival time at a compound dose of 200x2 mg/kgxdays, in mice bearing L1210 cells on days 1 and 5; Toxic1981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Synthesis of seleno- and thioguanine-platinum(II) complexes and their antitumor activity in mice.
AID230182The number of mice survived to that of total at a dose of 50 mg/kg on 30th day; 1/51981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Synthesis of seleno- and thioguanine-platinum(II) complexes and their antitumor activity in mice.
AID98799Median survival time when no dose was administered in mice bearing L1210 cells on days 1 and 51981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Synthesis of seleno- and thioguanine-platinum(II) complexes and their antitumor activity in mice.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]