5'-O-tritylinosine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 135526599 |
| CHEMBL ID | 386148 |
| SCHEMBL ID | 18044398 |
| MeSH ID | M0502746 |
| Synonym |
|---|
| 9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(trityloxymethyl)oxolan-2-yl]-3h-purin-6-one |
| 5''-o-tritylinosine |
| bdbm50194172 |
| 5'-o-tritylinosine |
| CHEMBL386148 , |
| SCHEMBL18044398 |
| AC-32250 |
| 4152-77-6 |
| 9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(trityloxymethyl)oxolan-2-yl]-1h-purin-6-one |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Thymidine phosphorylase | Escherichia coli K-12 | IC50 (µMol) | 44.0000 | 0.0027 | 1.7914 | 6.5000 | AID1055576 |
| Thymidine phosphorylase | Homo sapiens (human) | IC50 (µMol) | 48.5000 | 0.0200 | 1.5838 | 6.8000 | AID1055577; AID270128 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| 1,4-alpha-oligoglucan phosphorylase activity | Thymidine phosphorylase | Escherichia coli K-12 |
| thymidine phosphorylase activity | Thymidine phosphorylase | Escherichia coli K-12 |
| glycosyltransferase activity | Thymidine phosphorylase | Escherichia coli K-12 |
| pentosyltransferase activity | Thymidine phosphorylase | Escherichia coli K-12 |
| 1,4-alpha-oligoglucan phosphorylase activity | Thymidine phosphorylase | Homo sapiens (human) |
| protein binding | Thymidine phosphorylase | Homo sapiens (human) |
| growth factor activity | Thymidine phosphorylase | Homo sapiens (human) |
| thymidine phosphorylase activity | Thymidine phosphorylase | Homo sapiens (human) |
| protein homodimerization activity | Thymidine phosphorylase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| cytosol | Thymidine phosphorylase | Escherichia coli K-12 |
| membrane | Thymidine phosphorylase | Escherichia coli K-12 |
| cytosol | Thymidine phosphorylase | Escherichia coli K-12 |
| cytosol | Thymidine phosphorylase | Homo sapiens (human) |
| cytosol | Thymidine phosphorylase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID757782 | Antiviral activity against DENV serotype 2 NGC infected in mosquito C6/36 cells assessed as inhibition of virus-induced cytopathic effect after 1 week | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues. |
| AID1055577 | Non competitive inhibition of human recombinant thymidine phosphorylase using thymidine as substrate after 20 to 60 mins by HPLC analysis | 2013 | European journal of medicinal chemistry, , Volume: 70 | Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors. |
| AID1055576 | Noncompetitive inhibition of GST-tagged Escherichia coli recombinant thymidine phosphorylase expressed in Escherichia coli using thymidine as substrate after 20 to 60 mins by HPLC analysis | 2013 | European journal of medicinal chemistry, , Volume: 70 | Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors. |
| AID270130 | Inhibition of TPase-induced angiogenesis in chick chorioallantoic membrane at 100 nmol | 2006 | Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18 | 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. |
| AID757778 | Cytotoxicity against african green monkey Vero cells after 1 week | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues. |
| AID757780 | Cytotoxicity against mosquito C6/36 cells after 1 week | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues. |
| AID270128 | Inhibition of human TPase in presence of 100 uM thymidine | 2006 | Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18 | 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. |
| AID757779 | Antiviral activity against YFV 17D infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 1 week | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||