Page last updated: 2024-12-07

4'-o-methyldoxorubicin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4'-O-methyldoxorubicin: RN given refers to parent cpd(L-lyxo)-(8S-cis)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID100443
CHEMBL ID3230576
MeSH IDM0097097

Synonyms (8)

Synonym
4'-o-methyldoxorubicin
77121-90-5
nsc 301477
5,12-naphthacenedione, (10-(3-amino-2,3,6-trideoxy-4-o-methyl-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8s-cis)-
ccris 1432
3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-naphthacenyl 3-amino-2,3,6-trideoxy-4-o-methylhexopyranoside
(7s,9s)-7-[(2r,4s,5s,6s)-4-amino-5-methoxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione
CHEMBL3230576
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1123755Antitumor activity against mouse P388 cells allografted in ip dosed mouse assessed as optimal dose1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
Synthesis and antitumor activity of 4'-O-methyldaunorubicin, 4'-O-methyladriamycin, and their 4'-epi analogues.
AID1123764Antitumor activity against mouse L1210 cells allografted in mouse assessed as average survival time at 4.4 mg/kg, ip relative to untreated control1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
Synthesis and antitumor activity of 4'-O-methyldaunorubicin, 4'-O-methyladriamycin, and their 4'-epi analogues.
AID1123765Antitumor activity against mouse L1210 cells allografted in mouse assessed as average survival time at 6.6 mg/kg, ip relative to untreated control1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
Synthesis and antitumor activity of 4'-O-methyldaunorubicin, 4'-O-methyladriamycin, and their 4'-epi analogues.
AID1123762Toxicity in mouse allografted with mouse P388 cells at 6.6 mg/kg, ip1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
Synthesis and antitumor activity of 4'-O-methyldaunorubicin, 4'-O-methyladriamycin, and their 4'-epi analogues.
AID1123766Antitumor activity against mouse L1210 cells allografted in mouse assessed as average survival time at 10 mg/kg, ip relative to untreated control1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
Synthesis and antitumor activity of 4'-O-methyldaunorubicin, 4'-O-methyladriamycin, and their 4'-epi analogues.
AID1123758Antitumor activity against mouse P388 cells allografted in mouse assessed as average survival time at 6.6 mg/kg, ip relative to untreated control1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
Synthesis and antitumor activity of 4'-O-methyldaunorubicin, 4'-O-methyladriamycin, and their 4'-epi analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]