Page last updated: 2024-12-08

(1-chloroethenyl)oxirane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

(1-chloroethenyl)oxirane is a chemical name that isn't typically used. It's likely a synonym for **epichlorohydrin**, which is the more common and recognized name for this compound.

**Epichlorohydrin** is a three-carbon molecule with an epoxide ring (a cyclic ether with three atoms) and a chlorine atom attached to one of the carbon atoms. Its chemical formula is C₃H₅ClO.

**Importance for Research:**

Epichlorohydrin is an important building block in the chemical industry and is used in the synthesis of a wide variety of products, including:

* **Epoxy resins:** Epichlorohydrin is a key monomer in the production of epoxy resins, which are used in adhesives, coatings, and composites.
* **Glycerol:** Epichlorohydrin is used to produce glycerol, a versatile compound used in food, pharmaceuticals, and cosmetics.
* **Pharmaceuticals:** Epichlorohydrin is used in the production of certain pharmaceutical compounds.
* **Other applications:** Epichlorohydrin is also used in the production of polymers, surfactants, and other chemicals.

**Research Significance:**

* **Understanding its reactivity:** Researchers are interested in studying the chemical reactivity of epichlorohydrin, particularly its ability to undergo ring-opening reactions and polymerizations.
* **Developing new applications:** Researchers are exploring new applications for epichlorohydrin, such as in the synthesis of biocompatible materials and the development of new catalysts.
* **Environmental impact:** Epichlorohydrin is a potential environmental hazard. Researchers are investigating its environmental fate and the potential for it to contaminate water and soil.

Overall, epichlorohydrin is an important chemical that plays a vital role in many industries. Research into its properties, applications, and environmental impact is essential for both technological advancement and environmental protection.

(1-chloroethenyl)oxirane: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID231319
SCHEMBL ID3476857
MeSH IDM0405044

Synonyms (15)

Synonym
nsc-36615
3132-77-2
nsc27331
nsc-27331
nsc36615
(1-chloroethenyl)oxirane
2-(1-chloroethenyl)oxirane
oxirane,2-(1-chloroethenyl)-
SCHEMBL3476857
DTXSID60282683
2-chloro-3,4-epoxy-1-butene
EN300-22736566
nsc 36615
nsc 27331
Z2574917304

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" All three compounds showed signs of toxicity, with DEB being substantially more toxic than either CEO or EB."( In vitro genotoxicity testing of (1-chloroethenyl)oxirane, a metabolite of beta-chloroprene.
Donner, EM; Gladnick, NL; Himmelstein, MW; Snyder, RD; Valentine, R, 2001
)
0.59

Dosage Studied

ExcerptRelevanceReference
" A future goal is to use the kinetic rates to parameterize a physiologically based toxicokinetic model and relate the burden of toxic metabolite to the cancer dose-response observed in experimental animals."( The metabolism of beta-chloroprene: preliminary in-vitro studies using liver microsomes.
Carpenter, SC; Himmelstein, MW; Hinderliter, PM; Snow, TA; Valentine, R, 2001
)
0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (85.71)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.28 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]