1-dehydroprogesterone profile

1-dehydroprogesterone (1-DHP) is a synthetic steroid hormone that is a **potent agonist of the progesterone receptor**.

Here's why it's important for research:

* **Progesterone Receptor Research:** 1-DHP acts as a powerful tool to study the progesterone receptor and its signaling pathways. It's used to investigate the molecular mechanisms of progesterone action in various tissues and biological processes.
* **Drug Development:** 1-DHP is a promising lead compound for developing new drugs that target the progesterone receptor. Potential applications include:
* **Contraception:** Like progesterone itself, it can suppress ovulation.
* **Hormone Replacement Therapy (HRT):** It can potentially alleviate menopausal symptoms.
* **Treatment of Uterine Fibroids:** It might be effective in reducing the size of fibroids.
* **Cancer Treatment:** 1-DHP has shown potential in treating certain types of cancer, particularly those driven by progesterone receptor activity.
* **Animal Models:** 1-DHP is used to create animal models of various physiological and pathological conditions related to progesterone signaling, allowing researchers to study the effects of progesterone deficiency or excess in various systems.

**Important Note:** 1-DHP is a synthetic compound and not naturally occurring. It's typically used in laboratory settings and research, not as a therapeutic agent in the general population. Further research is needed to fully understand its potential benefits and risks.

1-dehydroprogesterone: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Delta(1)-progesterone : A 3-oxo Delta(4)-steroid that is progesterone which has been oxidised to introduce a double bond between positions 1 and 2. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	247929
CHEMBL ID	479717
CHEBI ID	34073
SCHEMBL ID	524063
MeSH ID	M0116821

Synonym
1,4-pregnadiene-3,20-dione
257v0w056g ,
unii-257v0w056g
CHEMBL479717
.delta.1-progesterone
pregna-1,20-dione
1162-54-5
mls002693437 ,
nsc63538
1,2-dehydroprogesterone
1-dehydroprogesterone
nsc-63538
nsc 63538
pregna-1,4-diene-3,20-dione
delta1-progesterone
1,2-didehydroprogesterone
3,20-dioxo-pregna-1,4-diene
CHEBI:34073 ,
3,20-dioxo-1,4-pregnadiene
delta(1)-progesterone
LMST02030147
(8s,9s,10r,13s,14s,17s)-17-acetyl-10,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
progesterone impurity j [ep impurity]
SCHEMBL524063
pregna-1,4-diene-3,20-dione #
(8s,9s,10r,13s,14s,17s)-17-acetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-3-one
DTXSID50921958
1,4-pregnadien-3,20-dione
Q27115793

Class	Description
20-oxo steroid	An oxo steroid carrying an oxo group at position 20.
3-oxo-Delta(1),Delta(4)-steroid	A 3-oxo-Delta(1) steroid containing an additional double bond between positions 4 and 5.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID1150123	Relative binding affinity to rabbit progesterone receptor	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Quantitative relationships between steroid structure and binding to putative progesterone receptors.
AID1150122	Relative binding affinity to sheep progesterone receptor	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Quantitative relationships between steroid structure and binding to putative progesterone receptors.
AID1150121	Relative binding affinity to human progesterone receptor	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Quantitative relationships between steroid structure and binding to putative progesterone receptors.
AID1150124	Relative binding affinity to guinea pig progesterone receptor	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Quantitative relationships between steroid structure and binding to putative progesterone receptors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (60.00)	18.7374
1990's	2 (40.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
corticosterone [no description available]	1.95	1	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone	human metabolite; mouse metabolite
norethindrone acetate norethisterone acetate : A 3-oxo Delta(4)-steroid that is norethisterone in which the hydroxy group has been converted to its acetate ester.	1.95	1	3-oxo-Delta(4) steroid; acetate ester; terminal acetylenic compound	progestin; synthetic oral contraceptive
lynestrenol Lynestrenol: A synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive (CONTRACEPTIVES, ORAL).	1.95	1	steroid
desoxycorticosterone acetate Desoxycorticosterone Acetate: The 21-acetate derivative of desoxycorticosterone.	1.95	1	corticosteroid hormone
androstenedione Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.. androst-4-ene-3,17-dione : A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.	1.95	1	17-oxo steroid; 3-oxo-Delta(4) steroid; androstanoid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
desoxycorticosterone Desoxycorticosterone: A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE	1.95	1	20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; mineralocorticoid; primary alpha-hydroxy ketone	human metabolite; mouse metabolite
norethindrone Norethindrone: A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for CONTRACEPTION.. norethisterone : A 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen.	1.95	1	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; terminal acetylenic compound; tertiary alcohol	progestin; synthetic oral contraceptive
norethynodrel Norethynodrel: A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and ENDOMETRIOSIS. As a contraceptive (CONTRACEPTIVE AGENTS), it has usually been administered in combination with MESTRANOL.	1.95	1	oxo steroid
17-alpha-hydroxyprogesterone 17alpha-hydroxyprogesterone : A 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone.	1.95	1	17alpha-hydroxy-C21-steroid; 17alpha-hydroxy steroid; tertiary alpha-hydroxy ketone	human metabolite; metabolite; mouse metabolite; progestin
medroxyprogesterone acetate [no description available]	1.95	1	20-oxo steroid; 3-oxo-Delta(4) steroid; acetate ester; corticosteroid; steroid ester	adjuvant; androgen; antineoplastic agent; antioxidant; female contraceptive drug; inhibitor; progestin; synthetic oral contraceptive
maleic anhydride Maleic Anhydrides: Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.. maleic anhydride : A cyclic dicarboxylic anhydride that is the cyclic anhydride of maleic acid.	1.97	1	cyclic dicarboxylic anhydride; furans	allergen
pregnenolone [no description available]	1.95	1	20-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; C21-steroid	human metabolite; mouse metabolite
20-alpha-dihydroprogesterone 20-alpha-Dihydroprogesterone: A biologically active 20-alpha-reduced metabolite of PROGESTERONE. It is converted from progesterone to 20-alpha-hydroxypregn-4-en-3-one by the 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE in the CORPUS LUTEUM and the PLACENTA.	1.95	1	20-hydroxypregn-4-en-3-one	human metabolite; mouse metabolite
chlormadinone acetate Chlormadinone Acetate: An orally active synthetic progestational hormone used often in combinations as an oral contraceptive (CONTRACEPTIVES, ORAL).	1.95	1	corticosteroid hormone
nandrolone Nandrolone: C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position.. nandrolone : A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.	1.95	1	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; anabolic androgenic steroid	human metabolite
dihydrotestosterone Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.	1.95	1	17beta-hydroxy steroid; 17beta-hydroxyandrostan-3-one; 3-oxo-5alpha-steroid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
megestrol acetate [no description available]	1.95	1	20-oxo steroid; 3-oxo-Delta(4) steroid; acetate ester; steroid ester	antineoplastic agent; appetite enhancer; contraceptive drug; progestin; synthetic oral contraceptive
levonorgestrel Levonorgestrel: A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.	1.95	1	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; terminal acetylenic compound	contraceptive drug; female contraceptive drug; progestin; synthetic oral contraceptive
norgestrienone Norgestrienone: A synthetic steroid with progestational and contraceptive activities.	1.95	1	steroid	estrogen
ethynodiol [no description available]	1.95	1	17beta-hydroxy steroid; 3beta-hydroxy steroid; terminal acetylenic compound	progestin
gestrinone Gestrinone: A non-estrogenic contraceptive which is a weak progestin with strong anti-progesterone properties. It is effective if used once a week orally or can also be used in intravaginal devices.	1.95	1	oxo steroid
promegestone Promegestone: A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.. promegestone : A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.	1.95	1	20-oxo steroid; 3-oxo-Delta(4) steroid	antineoplastic agent; progesterone receptor agonist; progestin
11-hydroxyprogesterone, (11alpha)-isomer 11alpha-hydroxyprogesterone : A 11alpha-hydroxy steroid that is pregn-4-ene-3,20-dione substituted by a hydroxy group at position 11.	1.95	1	11alpha-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(4) steroid
5beta-pregnane-3,20-dione 5beta-pregnane-3,20-dione : A C21-steroid that is 5beta-pregnane with oxo groups at positions 3 and 20.	1.95	1	20-oxo steroid; 3-oxo-5beta-steroid; C21-steroid	human metabolite; mouse metabolite
11-hydroxyprogesterone 11-hydroxyprogesterone: RN given refers to unspecified stereoisomer	1.97	1
5-alpha-dihydroprogesterone 5-alpha-Dihydroprogesterone: A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR.. 5alpha-pregnane-3,20-dione : A C21-steroid hormone that is 5alpha-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone.	1.95	1	20-oxo steroid; 3-oxo-5alpha-steroid; C21-steroid hormone	human metabolite; progestogen
demegestone demegestone: a norprogesterone derivative that acts like PROGESTERONE in increasing SEX HORMONE-BINDING GLOBULIN; structure	1.95	1	20-oxo steroid
11-ketoprogesterone 11-ketoprogesterone: structure	1.95	1	corticosteroid hormone
17 alpha-hydroxyprogesterone caproate 17 alpha-Hydroxyprogesterone Caproate: Hydroxyprogesterone derivative that acts as a PROGESTIN and is used to reduce the risk of recurrent MISCARRIAGE and of PREMATURE BIRTH. It is also used in combination with ESTROGEN in the management of MENSTRUATION DISORDERS.	1.95	1	corticosteroid hormone
19-norprogesterone 19-norprogesterone: RN given refers to cpd without isomeric designation	1.95	1	corticosteroid hormone
allylestrenol Allylestrenol: A synthetic steroid with progestational activity.	1.95	1	steroid
tibolone tibolone: used in prevention of postmenopausal osteoporosis. tibolone : Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.	1.95	1	17beta-hydroxy steroid; terminal acetylenic compound	bone density conservation agent; hormone agonist

1-dehydroprogesterone

Description

Cross-References

Synonyms (29)

Drug Classes (2)

Bioassays (4)

Research

Studies (5)

Market Indicators

Research Demand Index: 12.60

Study Types