Compounds > osaterone acetate
Page last updated: 2024-11-07

osaterone acetate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Osaterone acetate (also known as azasteroid or SH-265) is a synthetic steroid with antiandrogenic activity. Its synthesis involves the modification of testosterone, which is a naturally occurring male hormone. Research into osaterone acetate is focused on its potential as a treatment for various conditions, including acne, hirsutism (excessive hair growth), and prostate cancer. It works by blocking the action of testosterone in the body. Osaterone acetate has been studied in clinical trials for the treatment of acne and hirsutism. However, due to its side effects, its use is not widespread. Further research is needed to evaluate its efficacy and safety profile.'

osaterone acetate: structure given in first source; synthetic steroidal anti-androgen [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID114992
CHEBI ID81713
SCHEMBL ID528987
MeSH IDM0383181

Synonyms (30)

Synonym
osaterone acetate
hipros
tzp-4238
ccris 6738
17-alpha-acetoxy-6-chloro-2-oxa-4,6-pregnadiene-3,20-dione
tzp 4238
cyclopenta(5,6)naphtho(1,2-c)pyran-2(4h)-one, 7-acetyl-7-(acetyloxy)-11-chloro-4a,4b,5,6,6a,7,8,9,9a,9b-decahydro-4a,6a-dimethyl-, (4ar,4bs,6as,7r,9as,9br)-
17-(acetyloxy)-6-chloro-2-oxapregna-4,6-diene-3,20-dione
7-acetyl-7-(acetyloxy)-11-chloro-4ar,4b,5,6,6as,7r,8,9,9as,9br-decahydro-4a,6a-dimethylcyclopenta(5,6)naphtho(1,2-c)pyran-2(4h)-one
2-oxapregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-chloro-
osaterone acetate ester
[(1r,3as,3br,9ar,9bs,11as)-1-acetyl-5-chloro-9a,11a-dimethyl-7-oxo-2,3,3a,3b,9,9b,10,11-octahydroindeno[4,5-h]isochromen-1-yl] acetate
105149-00-6
C18375
fr26fsv5ez ,
unii-fr26fsv5ez
osaterone acetate [ema epar veterinary]
osaterone acetate [jan]
ypozane
osaterone acetate ester [mi]
2-oxochlormadinone acetate
SCHEMBL528987
CHEBI:81713
17alpha-acetoxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione
KKTIOMQDFOYCEN-OFUYBIASSA-N
osaterone acetate ester; tzp 4238
Q27155575
osaterone acetate (jan)
D11105
DTXSID501030455

Research Excerpts

Overview

Osaterone acetate (OA) is an androgen receptor antagonist marketed for treatment of canine BPH.

ExcerptReferenceRelevance
"Osaterone acetate (OA) is an androgen receptor antagonist marketed for treatment of canine BPH."( Prostatic fluid composition and semen quality in dogs with benign prostatic hyperplasia undergoing treatment with osaterone acetate.
Bedin, S; Contiero, B; Ferré-Dolcet, L; Frigotto, L; Romagnoli, S, 2022)		1.65

Pharmacokinetics

ExcerptReferenceRelevance
" In intact dogs, OA exhibited a biexponential disposition with a very long half-life of 197."( Pharmacokinetics and biliary excretion of osaterone acetate, a new steroidal antiandrogen, in dogs.
Honma, S; Iwamura, S; Koizumi, N; Minato, K; Tsukamoto, K, 2002)		0.58
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
20-oxo steroidAn oxo steroid carrying an oxo group at position 20.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (32)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's23 (71.88)18.2507
2000's6 (18.75)29.6817
2010's2 (6.25)24.3611
2020's1 (3.13)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 37.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index37.71 (24.57)
Research Supply Index3.64 (2.92)
Research Growth Index4.38 (4.65)
Search Engine Demand Index49.00 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (37.71)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials5 (15.63%)5.53%
Reviews1 (3.13%)6.00%
Case Studies1 (3.13%)4.05%
Observational0 (0.00%)0.25%
Other25 (78.13%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		1.9810aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
bromodeoxyuridine
Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.		2.3920pyrimidine 2'-deoxyribonucleosideantimetabolite;
antineoplastic agent
chlormadinone acetate
Chlormadinone Acetate: An orally active synthetic progestational hormone used often in combinations as an oral contraceptive (CONTRACEPTIVES, ORAL).		8.67325corticosteroid hormone
cyproterone acetate
[no description available]		1.981020-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
chlorinated steroid;
steroid ester		androgen antagonist;
geroprotector;
progestin
dihydrotestosterone
Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.		2.94017beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
androstane-3,17-diol
Androstane-3,17-diol: The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.		2.382017-hydroxy steroid;
3-hydroxy steroid;
androstanoid
cyproterone
Cyproterone: An anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.		1.981017alpha-hydroxy steroid;
20-oxo steroid;
3-oxo-Delta(4) steroid;
chlorinated steroid;
tertiary alpha-hydroxy ketone		androgen antagonist
delmadinone
[no description available]		3.4311
ConditionIndicatedRelationship StrengthStudiesTrials
Canine Diseases
[description not available]		05.152
Adenoma, Prostatic
[description not available]		06.79145
Prostatic Hyperplasia
Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.		06.79145
Monkey Diseases
Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).		02.1310
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		01.9810
Cancer of Prostate
[description not available]		01.9810
Hormone-Dependent Neoplasms
[description not available]		01.9810
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		01.9810
Bladder Neck Obstruction
[description not available]		03.3711
Anoxemia
[description not available]		01.9810
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms.		01.9810
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.3920
Hyperventilation
A pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide.		01.9710