Compounds > isoerianin
Page last updated: 2024-11-13

isoerianin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID44511349
CHEMBL ID2022455
SCHEMBL ID12635121
MeSH IDM0576544

Synonyms (4)

Synonym
isoerianin
CHEMBL2022455
SCHEMBL12635121
bdbm50494618
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Tubulin alpha-1A chainSus scrofa (pig)IC50 (µMol)21.50000.00672.160310.0000AID1057124
Tubulin beta chainSus scrofa (pig)IC50 (µMol)21.50000.00672.137410.0000AID1057124
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID1126648Antiproliferative activity against HUVEC in endothelial cell growth medium containing growth factors after 72 hrs by resazurin dye-based fluorimetric analysis2014European journal of medicinal chemistry, May-06, Volume: 78Discovery of azaisoerianin derivatives as potential antitumors agents.
AID658261Cytotoxicity against human MDA-MB-231 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis2012European journal of medicinal chemistry, Jun, Volume: 52Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.
AID1057119Chemical stability of the compound in PBS at pH 7.4 assessed as compound remaining after 6.5 hrs by HPLC analysis2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
AID1126643Inhibition of sheep brain tubulin assembly by DAPI-staining based fluorescence assay2014European journal of medicinal chemistry, May-06, Volume: 78Discovery of azaisoerianin derivatives as potential antitumors agents.
AID1057123Displacement of [3H]colchicine from tubulin (unknown origin) at 3 uM after 30 mins by scintillation counting2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
AID1126642Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by resazurin dye-based fluorimetric analysis2014European journal of medicinal chemistry, May-06, Volume: 78Discovery of azaisoerianin derivatives as potential antitumors agents.
AID1126658Antiangiogenic activity in human ECFC co-cultured with human ADSC assessed as inhibition of VEGF-induced endothelial colony tube formation after 96 hrs2014European journal of medicinal chemistry, May-06, Volume: 78Discovery of azaisoerianin derivatives as potential antitumors agents.
AID1126645Cytotoxicity against hormone-independent human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by resazurin dye-based fluorimetric analysis2014European journal of medicinal chemistry, May-06, Volume: 78Discovery of azaisoerianin derivatives as potential antitumors agents.
AID1126647Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by resazurin dye-based fluorimetric analysis2014European journal of medicinal chemistry, May-06, Volume: 78Discovery of azaisoerianin derivatives as potential antitumors agents.
AID1057127Cytotoxicity against human MCF7 cells after 3 days2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
AID1348617Antiproliferative activity against human HCT116 cells after 72 hrs by resazurin-based fluorescence assay2018European journal of medicinal chemistry, Jan-01, Volume: 143A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation.
AID1126646Cytotoxicity against human U87MG cells assessed as growth inhibition after 72 hrs by resazurin dye-based fluorimetric analysis2014European journal of medicinal chemistry, May-06, Volume: 78Discovery of azaisoerianin derivatives as potential antitumors agents.
AID658259Cytotoxicity against human HCT116 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis2012European journal of medicinal chemistry, Jun, Volume: 52Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.
AID658263Inhibition of sheep brain tubulin polymerization using DAPI by fluorescence assay2012European journal of medicinal chemistry, Jun, Volume: 52Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.
AID1057128Inhibition of porcine brain tubulin polymerization at 30 uM by turbidity assay2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
AID1057124Inhibition of porcine brain tubulin polymerization by turbidity assay2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
AID658262Cytotoxicity against human K562 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis2012European journal of medicinal chemistry, Jun, Volume: 52Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.
AID658260Cytotoxicity against human H1299 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis2012European journal of medicinal chemistry, Jun, Volume: 52Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.
AID1057121Displacement of [3H]colchicine from tubulin (unknown origin) at 30 uM after 30 mins by scintillation counting2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
AID1057118Chemical stability of the compound in PBS at pH 7.4 assessed as compound remaining after 24 hrs by HPLC analysis2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
AID1191392Cytotoxicity against human HCT116 cells after 72 hrs by CellTitre-Blue assay2015European journal of medicinal chemistry, Jan-27, Volume: 90Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents.
AID1057120Chemical stability of the compound in PBS at pH 7.4 assessed as compound remaining after 4 hrs by HPLC analysis2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
AID1057122Displacement of [3H]colchicine from tubulin (unknown origin) at 10 uM after 30 mins by scintillation counting2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		2.1710aromatic ether;
nitrile;
polyether;
tertiary amino compound
procaine
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).. procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.		2.1710benzoate ester;
substituted aniline;
tertiary amino compound		central nervous system depressant;
drug allergen;
local anaesthetic;
peripheral nervous system drug
fosbretabulin
[no description available]		3.250stilbenoid
isocombretastatin a-4
[no description available]		8.0240
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.0810
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0810