Pathways > Signaling by VEGF
Page last updated: 2024-10-06

Signaling by VEGF

Proteins (60)

ProteinSynonymsTaxonomy
NucleoproteinN; Nucleocapsid protein; NC; Protein NSevere acute respiratory syndrome coronavirus 2
Neutrophil cytosol factor 1NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phoxHomo sapiens (human)
Target of rapamycin complex 2 subunit MAPKAP1TORC2 subunit MAPKAP1; Mitogen-activated protein kinase 2-associated protein 1; Stress-activated map kinase-interacting protein 1; SAPK-interacting protein 1; mSIN1Homo sapiens (human)
3-phosphoinositide-dependent protein kinase 1hPDK1; EC 2.7.11.1Homo sapiens (human)
Integrin beta-3Platelet membrane glycoprotein IIIa; GPIIIaHomo sapiens (human)
Tyrosine-protein kinase FynEC 2.7.10.2; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-FynHomo sapiens (human)
Heat shock protein HSP 90-alphaEC 3.6.4.10; Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38Homo sapiens (human)
Tyrosine-protein kinase receptor UFOEC 2.7.10.1; AXL oncogeneHomo sapiens (human)
RAC-alpha serine/threonine-protein kinaseEC 2.7.11.1; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alphaHomo sapiens (human)
Vascular endothelial growth factor receptor 2VEGFR-2; EC 2.7.10.1; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1Homo sapiens (human)
Focal adhesion kinase 1FADK 1; EC 2.7.10.2; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAKHomo sapiens (human)
Serine/threonine-protein kinase PAK 1EC 2.7.11.1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAKHomo sapiens (human)
Protein-tyrosine kinase 2-betaEC 2.7.10.2; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Proline-rich tyrosine kinase 2; Related adhesion focal tyrosineHomo sapiens (human)
Sphingosine kinase 1SK 1; SPK 1; EC 2.7.1.91; Acetyltransferase SPHK1; 2.3.1.-Homo sapiens (human)
Dedicator of cytokinesis protein 1180 kDa protein downstream of CRK; DOCK180Homo sapiens (human)
SH2 domain-containing adapter protein BHomo sapiens (human)
PaxillinHomo sapiens (human)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1EC 3.1.4.11; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1Homo sapiens (human)
Serine/threonine-protein kinase PAK 3EC 2.7.11.1; Beta-PAK; Oligophrenin-3; p21-activated kinase 3; PAK-3Homo sapiens (human)
Integrin alpha-V Vitronectin receptor; Vitronectin receptor subunit alphaHomo sapiens (human)
Vascular endothelial growth factor receptor 1 VEGFR-1; EC 2.7.10.1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; FLT; Vascular permeability factor receptorHomo sapiens (human)
Vascular endothelial growth factor receptor 3VEGFR-3; EC 2.7.10.1; Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4Homo sapiens (human)
Serine/threonine-protein kinase mTOREC 2.7.11.1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1Homo sapiens (human)
Cell division control protein 42 homologEC 3.6.5.2; G25K GTP-binding proteinHomo sapiens (human)
Catenin alpha-1Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13Homo sapiens (human)
Caveolin-1Homo sapiens (human)
S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like molecule; IP(3)Rs binding protein released with IP(3); IRBIT; Putative adenosylhomocysteinase 2; S-adenosyl-L-homocysteine hydrolase 2; AdoHcyase 2Homo sapiens (human)
Neuropilin-1Vascular endothelial cell growth factor 165 receptorHomo sapiens (human)
Vascular endothelial growth factor AVEGF-A; Vascular permeability factor; VPFHomo sapiens (human)
Adapter molecule crkProto-oncogene c-Crk; p38Homo sapiens (human)
Placenta growth factorPlGFHomo sapiens (human)
Ras-related C3 botulinum toxin substrate 1EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1Homo sapiens (human)
SH2 domain-containing protein 2ASH2 domain-containing adapter protein; T cell-specific adapter protein; TSAd; VEGF receptor-associated proteinHomo sapiens (human)
Heat shock protein beta-1HspB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27Homo sapiens (human)
Cytochrome b-245 heavy chainEC 1.-.-.-; CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; Superoxide-generating NADPH oxidase heavy chain subunit; gp91-1Homo sapiens (human)
Calmodulin-1Homo sapiens (human)
Nitric oxide synthase, endothelialEC 1.14.13.39; Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III; NOSIIIHomo sapiens (human)
Transforming protein RhoAEC 3.6.5.2; Rho cDNA clone 12; h12Homo sapiens (human)
Serine/threonine-protein kinase PAK 2EC 2.7.11.1; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58Homo sapiens (human)
Rapamycin-insensitive companion of mTORAVO3 homolog; hAVO3Homo sapiens (human)
Target of rapamycin complex subunit LST8TORC subunit LST8; G protein beta subunit-like; Gable; Protein GbetaL; Mammalian lethal with SEC13 protein 8; mLST8Homo sapiens (human)
SHC-transforming protein 2Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2Homo sapiens (human)
Vascular endothelial growth factor DVEGF-D; c-Fos-induced growth factor; FIGFHomo sapiens (human)
Vascular endothelial growth factor BVEGF-B; VEGF-related factor; VRFHomo sapiens (human)
Vascular endothelial growth factor CVEGF-C; Flt4 ligand; Flt4-L; Vascular endothelial growth factor-related protein; VRPHomo sapiens (human)
Membrane proteinM; E1 glycoprotein; Matrix glycoprotein; Membrane glycoproteinSevere acute respiratory syndrome coronavirus 2
Neuropilin-2Vascular endothelial cell growth factor 165 receptor 2Homo sapiens (human)
Protein BRICK1BRK1Homo sapiens (human)
Catenin delta-1Cadherin-associated Src substrate; CAS; p120 catenin; p120(ctn); p120(cas)Homo sapiens (human)
Breast cancer anti-estrogen resistance protein 1CRK-associated substrate; Cas scaffolding protein family member 1; p130casHomo sapiens (human)
Ras GTPase-activating protein 1GAP; GTPase-activating protein; RasGAP; Ras p21 protein activator; p120GAPHomo sapiens (human)
Cytochrome b-245 light chainCytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phoxHomo sapiens (human)
Neutrophil cytosol factor 2NCF-2; 67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; Neutrophil NADPH oxidase factor 2; p67-phoxHomo sapiens (human)
Cadherin-57B4 antigen; Vascular endothelial cadherin; VE-cadherinHomo sapiens (human)
Nck-associated protein 1-likeHematopoietic protein 1; Membrane-associated protein HEM-1Homo sapiens (human)
Proline-rich protein 5Protein observed with Rictor-1; Protor-1Homo sapiens (human)
Angio-associated migratory cell proteinHomo sapiens (human)
Neutrophil cytosol factor 4 NCF-4; Neutrophil NADPH oxidase factor 4; SH3 and PX domain-containing protein 4; p40-phox; p40phoxHomo sapiens (human)
Brain-specific angiogenesis inhibitor 1-associated protein 2BAI-associated protein 2; BAI1-associated protein 2; Protein BAP2; Fas ligand-associated factor 3; FLAF3; Insulin receptor substrate p53/p58; IRS-58; IRSp53/58; Insulin receptor substrate protein of 53 kDa; IRSp53; Insulin receptor substrate p53Homo sapiens (human)
Nck-associated protein 1NAP 1; Membrane-associated protein HEM-2; p125Nap1Homo sapiens (human)

Compounds (22)

CompoundDescription
hydronium ion
Nitric OxideA free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
ArginineAn essential amino acid that is physiologically active in the L-form.
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
SuperoxidesHighly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
guanosine diphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
sapropterinRN given refers to parent cpd; co-factor required for catalytic activity of nitric oxide synthases
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
sphingosine 1-phosphateRN given refers to (R-(R*,S*-(E)))-isomer; RN for cpd without isomeric designation not available 8/89
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
hemeThe color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.
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