Page last updated: 2024-10-06

Macroautophagy

Proteins (54)

ProteinSynonymsTaxonomy
E3 ubiquitin-protein ligase parkinParkin; EC 2.3.2.31; Parkin RBR E3 ubiquitin-protein ligase; Parkinson juvenile disease protein 2; Parkinson disease protein 2Homo sapiens (human)
Mitofusin-2EC 3.6.5.-; Transmembrane GTPase MFN2Homo sapiens (human)
Sequestosome-1EBI3-associated protein of 60 kDa; EBIAP; p60; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62Homo sapiens (human)
Beclin-1Coiled-coil myosin-like BCL2-interacting protein; Protein GT197Homo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase 30EC 3.4.19.12; Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30Homo sapiens (human)
Microtubule-associated proteins 1A/1B light chain 3BAutophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light chain 3 betaHomo sapiens (human)
Heat shock protein HSP 90-alphaEC 3.6.4.10; Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38Homo sapiens (human)
Phosphatidylinositol 3-kinase catalytic subunit type 3PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3; EC 2.7.1.137; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34Homo sapiens (human)
Histone deacetylase 6HD6; EC 3.5.1.98; Tubulin-lysine deacetylase HDAC6; 3.5.1.-Homo sapiens (human)
Mitochondrial import receptor subunit TOM40 homologProtein Haymaker; Translocase of outer membrane 40 kDa subunit homolog; p38.5Homo sapiens (human)
Serine/threonine-protein kinase ULK1EC 2.7.11.1; Autophagy-related protein 1 homolog; ATG1; hATG1; Unc-51-like kinase 1Homo sapiens (human)
Casein kinase II subunit betaCK II beta; Phosvitin; Protein G5aHomo sapiens (human)
Endothelial PAS domain-containing protein 1EPAS-1; Basic-helix-loop-helix-PAS protein MOP2; Class E basic helix-loop-helix protein 73; bHLHe73; HIF-1-alpha-like factor; HLF; Hypoxia-inducible factor 2-alpha; HIF-2-alpha; HIF2-alpha; Member of PAS protein 2; PAS domain-containing protein 2Homo sapiens (human)
UV radiation resistance-associated gene proteinp63Homo sapiens (human)
Heat shock cognate 71 kDa proteinEC 3.6.4.10; Heat shock 70 kDa protein 8; Lipopolysaccharide-associated protein 1; LAP-1; LPS-associated protein 1Homo sapiens (human)
Heat shock factor protein 1HSF 1; Heat shock transcription factor 1; HSTF 1Homo sapiens (human)
Phosphoinositide 3-kinase regulatory subunit 4PI3-kinase regulatory subunit 4; EC 2.7.11.1; PI3-kinase p150 subunit; Phosphoinositide 3-kinase adaptor proteinHomo sapiens (human)
Serine/threonine-protein kinase PINK1, mitochondrialEC 2.7.11.1; BRPK; PTEN-induced putative kinase protein 1Homo sapiens (human)
Ubiquitin-like modifier-activating enzyme ATG7ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; APG7-like; hAGP7; Ubiquitin-activating enzyme E1-like proteinHomo sapiens (human)
5'-AMP-activated protein kinase catalytic subunit alpha-2AMPK subunit alpha-2; EC 2.7.11.1; Acetyl-CoA carboxylase kinase; ACACA kinase; 2.7.11.27; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; 2.7.11.31Homo sapiens (human)
Transitional endoplasmic reticulum ATPaseTER ATPase; EC 3.6.4.6; 15S Mg(2+)-ATPase p97 subunit; Valosin-containing protein; VCPHomo sapiens (human)
Ubiquitin-conjugating enzyme E2 NEC 2.3.2.23; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; Ubc13; UbcH13; Ubiquitin carrier protein N; Ubiquitin-protein ligase NHomo sapiens (human)
Serine-protein kinase ATMEC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutatedHomo sapiens (human)
Ubiquitin-conjugating enzyme E2 variant 1UEV-1; CROC-1; TRAF6-regulated IKK activator 1 beta Uev1AHomo sapiens (human)
Ubiquitin-like protein ATG12Autophagy-related protein 12; APG12-likeHomo sapiens (human)
GTP-binding protein RhebRas homolog enriched in brainHomo sapiens (human)
Transcription termination factor 3, mitochondrialMitochondrial transcription termination factor 3; mTERF3; mTERF domain-containing protein 1, mitochondrialHomo sapiens (human)
Voltage-dependent anion-selective channel protein 1VDAC-1; hVDAC1; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HMHomo sapiens (human)
Charged multivesicular body protein 6Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20Homo sapiens (human)
Mitofusin-1EC 3.6.5.-; Fzo homolog; Transmembrane GTPase MFN1Homo sapiens (human)
RB1-inducible coiled-coil protein 1FAK family kinase-interacting protein of 200 kDa; FIP200Homo sapiens (human)
Cytoplasmic dynein 1 heavy chain 1Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolicHomo sapiens (human)
Autophagy-related protein 13Homo sapiens (human)
Mitochondrial import receptor subunit TOM70Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit; Translocase of outer mitochondrial membrane protein 70Homo sapiens (human)
TuberinTuberous sclerosis 2 proteinHomo sapiens (human)
Peroxisomal targeting signal 1 receptorPTS1 receptor; PTS1R; PTS1-BP; Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; Peroxisome receptor 1Homo sapiens (human)
Next to BRCA1 gene 1 proteinCell migration-inducing gene 19 protein; Membrane component chromosome 17 surface marker 2; Neighbor of BRCA1 gene 1 protein; Protein 1A1-3BHomo sapiens (human)
Mitochondrial import receptor subunit TOM20 homologMitochondrial 20 kDa outer membrane protein; Outer mitochondrial membrane receptor Tom20Homo sapiens (human)
Autophagy-related protein 16-1APG16-like 1Homo sapiens (human)
Beclin 1-associated autophagy-related key regulatorBarkor; Autophagy-related protein 14-like protein; Atg14LHomo sapiens (human)
FUN14 domain-containing protein 1Homo sapiens (human)
Mitochondrial import receptor subunit TOM5 homologHomo sapiens (human)
Charged multivesicular body protein 7Chromatin-modifying protein 7Homo sapiens (human)
HamartinTuberous sclerosis 1 proteinHomo sapiens (human)
Mitochondrial import receptor subunit TOM6 homologOverexpressed breast tumor protein; Translocase of outer membrane 6 kDa subunit homologHomo sapiens (human)
Autophagy-related protein 101Homo sapiens (human)
Activating molecule in BECN1-regulated autophagy protein 1Homo sapiens (human)
Ubiquitin-like-conjugating enzyme ATG10EC 2.3.2.-; Autophagy-related protein 10; APG10-likeHomo sapiens (human)
Autophagy protein 5APG5-like; Apoptosis-specific proteinHomo sapiens (human)
Mitochondrial import receptor subunit TOM22 homologhTom22; 1C9-2; Translocase of outer membrane 22 kDa subunit homologHomo sapiens (human)
Ubiquitin-like-conjugating enzyme ATG3EC 2.3.2.-; Autophagy-related protein 3; APG3-like; hApg3; Protein PC3-96Homo sapiens (human)
Mitochondrial import receptor subunit TOM7 homologTranslocase of outer membrane 7 kDa subunit homologHomo sapiens (human)
Charged multivesicular body protein 3Chromatin-modifying protein 3; Neuroendocrine differentiation factor; Vacuolar protein sorting-associated protein 24; hVps24Homo sapiens (human)
WD repeat domain phosphoinositide-interacting protein 2WIPI-2; WIPI49-like protein 2Homo sapiens (human)

Compounds (7)

CompoundDescription
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.