way 100135 has been researched along with buspirone in 12 studies
| Studies (way 100135) | Trials (way 100135) | Recent Studies (post-2010) (way 100135) | Studies (buspirone) | Trials (buspirone) | Recent Studies (post-2010) (buspirone) |
|---|---|---|---|---|---|
| 143 | 0 | 34 | 2,096 | 351 | 382 |
| Protein | Taxonomy | way 100135 (IC50) | buspirone (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.025 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 1.75 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.024 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.323 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 2.125 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 4.16 | |
| D | Rattus norvegicus (Norway rat) | 0.12 | |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | 0.12 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.0266 | |
| D(2) dopamine receptor | Bos taurus (cattle) | 4 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 4.16 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.077 | |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | 0.12 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 2.286 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.016 | |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | 0.12 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 2.125 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.044 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.75 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 4.16 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 0.2055 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 3.9811 | |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | 0.025 | |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 1.7 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.2666 | |
| Lysosomal alpha-glucosidase | Bos taurus (cattle) | 0.03 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (66.67) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brightwell, CI; Cliffe, IA; Fletcher, A; Forster, EA; Mansell, HL; Reilly, Y; Routledge, C; White, AC | 1 |
| Chaput, C; Millan, MJ; Newman-Tancredi, A; Verrièle, L | 1 |
| Ashworth-Preece, MA; Dourish, CT; Gurling, J; Routledge, C | 1 |
| Dourish, CT; Gurling, J; Routledge, C; Wright, IK | 1 |
| Bietti, G; Borsini, F; Ceci, A; Donetti, A | 1 |
| Fijał, K; Gołembiowska, K; Maćkowiak, M; Wedzony, K | 1 |
| Dawson, LA; Nguyen, HQ | 1 |
| Comoy, E; Lesourd, M; Protais, P | 1 |
| Bronowska, A; Dahl, SG; Sylte, I | 1 |
| Assié, MB; Colpaert, FC; Cosi, C; Koek, W; Patoiseau, JF; Pauwels, PJ; Vacher, B | 1 |
| Borsini, F; Cassano, GB; Giromella, A; Lucacchini, A; Marazziti, D; Mayer, N; Mazzoni, MR; Naccarato, AG; Palego, L | 1 |
| Arcaro, V; Ballabeni, V; Barocelli, E; Bertoni, S; Cantoni, AM; Domenichini, G; Flammini, L; Rapalli, A; Saccani, F; Tognolini, M; Vivo, V | 1 |
12 other study(ies) available for way 100135 and buspirone
| Article | Year |
|---|---|
(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.
Topics: Animals; Binding Sites; Piperazines; Rats; Receptors, Serotonin; Serotonin Antagonists; Stereoisomerism; Synapses | 1993 |
Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Affinity Labels; Animals; Binding, Competitive; CHO Cells; Cricetinae; Guanine Nucleotides; Hippocampus; Humans; Male; Membranes; Piperazines; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1998 |
Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190.
Topics: Animals; Buspirone; Drug Interactions; Extracellular Space; Hippocampus; Injections, Subcutaneous; Male; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stereotaxic Techniques | 1995 |
Neurochemical profile of the selective and silent 5-HT1A receptor antagonist WAY100135: an in vivo microdialysis study.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dopamine; Hippocampus; Injections, Subcutaneous; Male; Microdialysis; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Stereoisomerism | 1993 |
BIMT 17, a 5-HT1A receptor agonist/5-HT2A receptor antagonist, directly activates postsynaptic 5-HT inhibitory responses in the rat cerebral cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Antidepressive Agents; Benzimidazoles; Binding, Competitive; Buspirone; Cerebral Cortex; Dose-Response Relationship, Drug; In Vitro Techniques; Iontophoresis; Male; Microelectrodes; Neurons; Piperazines; Prazosin; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes | 1995 |
Ipsapirone enhances the dopamine outflow via 5-HT1A receptors in the rat prefrontal cortex.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Buspirone; Dopamine; Homovanillic Acid; Male; Microdialysis; Piperazines; Prefrontal Cortex; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists | 1996 |
Effects of 5-HT1A receptor antagonists on fluoxetine-induced changes in extracellular serotonin concentrations in rat frontal cortex.
Topics: Animals; Buspirone; Cyclohexanes; Extracellular Space; Fluoxetine; Male; Microdialysis; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1998 |
Similar pharmacological properties of 8-OH-DPAT and alnespirone (S 20499) at dopamine receptors: comparison with buspirone.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Apomorphine; Behavior, Animal; Benzazepines; Buspirone; Corpus Striatum; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Male; Mice; Piperazines; Raclopride; Salicylamides; Serotonin; Serotonin Antagonists; Spiro Compounds; Tritium | 1998 |
Ligand induced conformational states of the 5-HT(1A) receptor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Binding, Competitive; Buspirone; Ligands; Models, Molecular; Molecular Structure; Piperazines; Protein Conformation; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Rhodopsin; Serotonin Antagonists; Serotonin Receptor Agonists; Thermodynamics | 2001 |
5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Antidepressive Agents; Binding, Competitive; Buspirone; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Male; Motor Activity; Piperazines; Piperidines; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 2001 |
Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Aged; Aged, 80 and over; Benzimidazoles; Binding, Competitive; Brain; Buspirone; Colforsin; Dose-Response Relationship, Drug; Female; Hippocampus; Humans; Male; Middle Aged; Piperazines; Prefrontal Cortex; Raphe Nuclei; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2002 |
Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Buspirone; Female; Heme Oxygenase-1; Interleukin-1beta; Intestinal Mucosa; Intestines; Malondialdehyde; Membrane Proteins; Mice; Nicotinic Antagonists; Peroxidase; Piperazines; Receptor, Serotonin, 5-HT1A; Reperfusion Injury; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Tumor Necrosis Factor-alpha | 2014 |