Page last updated: 2024-09-02

r 56865 and flunarizine

r 56865 has been researched along with flunarizine in 11 studies

Compound Research Comparison

Studies
(r 56865)
Trials
(r 56865)
Recent Studies (post-2010)
(r 56865)
Studies
(flunarizine)
Trials
(flunarizine)
Recent Studies (post-2010) (flunarizine)
72101,269189153

Protein Interaction Comparison

ProteinTaxonomyr 56865 (IC50)flunarizine (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.669
Bile salt export pumpHomo sapiens (human)10
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)0.49
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.339
Muscarinic acetylcholine receptor M4Homo sapiens (human)5.656
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.107
Alpha-2A adrenergic receptorHomo sapiens (human)0.581
Adenosine receptor A3Homo sapiens (human)5.198
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.936
Cytochrome P450 2C9 Homo sapiens (human)0.94
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.6058
D(2) dopamine receptorHomo sapiens (human)0.352
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)5.198
Alpha-2B adrenergic receptorHomo sapiens (human)1.893
Alpha-2C adrenergic receptorHomo sapiens (human)0.222
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)4.281
Muscarinic acetylcholine receptor M3Homo sapiens (human)1.479
Cannabinoid receptor 1Homo sapiens (human)3.028
D(1A) dopamine receptorHomo sapiens (human)3.874
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.339
Alpha-1D adrenergic receptorHomo sapiens (human)1.085
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.407
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.669
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)4.281
Sodium-dependent serotonin transporterHomo sapiens (human)0.499
Delta-type opioid receptorMus musculus (house mouse)1.67
Histamine H1 receptorHomo sapiens (human)0.158
Mu-type opioid receptorHomo sapiens (human)5.236
D(3) dopamine receptorHomo sapiens (human)0.097
5-hydroxytryptamine receptor 2BHomo sapiens (human)1.088
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)5.198
Cytochrome P450 2J2Homo sapiens (human)0.8833
Voltage-dependent L-type calcium channel subunit beta-1Rattus norvegicus (Norway rat)0.08
Voltage-dependent calcium channel subunit alpha-2/delta-1Rattus norvegicus (Norway rat)0.08
D(2) dopamine receptorRattus norvegicus (Norway rat)0.228
Voltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)1.67
Sodium-dependent dopamine transporter Homo sapiens (human)0.584
Voltage-dependent N-type calcium channel subunit alpha-1BRattus norvegicus (Norway rat)0.08
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.6058
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)0.6058
Potassium channel subfamily K member 2 Bos taurus (cattle)2.5
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.025
Prostaglandin D2 receptor 2Homo sapiens (human)0.08

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's10 (90.91)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Borgers, M; Geerts, H; Ver Donck, L; Verellen, G1
Gleitz, J; Peters, T; Tegtmeier, F; Urenjak, J; Wermelskirchen, D; Wilffert, B1
Nebel, U; Wermelskirchen, D; Wilffert, B; Wirth, A1
Scheufler, E; Vogelgesang, R1
Peters, T; Scheufler, E1
Borgers, M; De Clerck, F; Vandewiele, R; Ver Donck, L; Verellen, G1
Koch, P; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wilhelm, D1
Hoff, P; Tegtmeier, F; Xie, Y; Zacharias, E1
Krishtal, OA; Panchenko, VA; Tegtmeier, F1
Chizhmakov, IV; Kiskin, NI; Krishtal, OA; Tegtmeier, F1
Ishide, N1

Reviews

1 review(s) available for r 56865 and flunarizine

ArticleYear
Intracellular calcium modulators for cardiac muscle in pathological conditions.
    Japanese heart journal, 1996, Volume: 37, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; Benzothiazoles; Caffeine; Calcium; Calcium Channel Blockers; Dantrolene; Flunarizine; Homeostasis; Humans; Magnesium; Models, Cardiovascular; Muscle Relaxants, Central; Myocardial Contraction; Myocardium; Phenytoin; Piperidines; Ryanodine; Sarcoplasmic Reticulum; Thiazepines; Thiazoles

1996

Other Studies

10 other study(ies) available for r 56865 and flunarizine

ArticleYear
Lysophosphatidylcholine-induced Ca(2+)-overload in isolated cardiomyocytes and effect of cytoprotective drugs.
    Journal of molecular and cellular cardiology, 1992, Volume: 24, Issue:9

    Topics: Animals; Benzothiazoles; Calcium; Flunarizine; Heart; Histocytochemistry; In Vitro Techniques; Intracellular Fluid; Ion Transport; Lysophosphatidylcholines; Microscopy, Electron; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Piperidines; Rabbits; Thiazoles

1992
Flunarizine and R 56865 suppress veratridine-induced increase in oxygen consumption and uptake of 45Ca2+ in rat cortical synaptosomes.
    Neuropharmacology, 1992, Volume: 31, Issue:3

    Topics: Animals; Benzothiazoles; Calcium; Calcium Radioisotopes; Cerebral Cortex; Flunarizine; In Vitro Techniques; Oxygen Consumption; Piperidines; Polarography; Rats; Synaptosomes; Tetrodotoxin; Thiazoles; Veratridine

1992
45Ca2+ movements induced by Ca2+ chloride in isolated rat aorta under K(+)-free conditions.
    European journal of pharmacology, 1991, Jan-17, Volume: 192, Issue:3

    Topics: Amiloride; Animals; Aorta, Thoracic; Benzothiazoles; Calcium; Calcium Chloride; Calcium Radioisotopes; Flunarizine; In Vitro Techniques; Indomethacin; Lanthanum; Lidocaine; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Piperidines; Potassium; Rats; Thiazoles; Vasoconstriction

1991
R 56865 and flunarizine displace Ca2+ from phosphatidylserine monolayers in a stoichiometric manner.
    European journal of pharmacology, 1990, Jan-23, Volume: 188, Issue:1

    Topics: Benzothiazoles; Binding, Competitive; Calcium; Calcium Radioisotopes; Flunarizine; Hydrogen-Ion Concentration; Membranes, Artificial; Phosphatidylserines; Piperidines; Thiazoles

1990
Phosphatidylserine monolayers as models for drug uptake into membranes and tissue.
    Cell biology international reports, 1990, Volume: 14, Issue:4

    Topics: Animals; Aorta; Benzothiazoles; Cell Membrane; Diltiazem; Erythrocyte Membrane; Flunarizine; Heart Atria; Humans; Lidocaine; Membranes, Artificial; Models, Biological; Nitrendipine; Pharmaceutical Preparations; Pharmacokinetics; Phosphatidylserines; Piperidines; Rats; Thiazoles; Verapamil

1990
Class IV Ca2+ antagonists do not affect lipid peroxidation in singlet oxygen challenged cardiomyocytes.
    Cell biology international reports, 1990, Volume: 14, Issue:4

    Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cell Separation; Cinnarizine; Diltiazem; Flunarizine; Lidoflazine; Lipid Peroxidation; Malondialdehyde; Myocardium; Nicardipine; Oxygen; Piperidines; Rats; Thiazoles; Verapamil

1990
Different effects of R 56865 and calcium entry blockers on K+- and noradrenaline-induced contractions and 45Ca uptake in rat aorta.
    European journal of pharmacology, 1988, Dec-13, Volume: 158, Issue:3

    Topics: Animals; Aorta; Benzothiazoles; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Flunarizine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles; Verapamil

1988
Ion channel involvement in anoxic depolarization induced by cardiac arrest in rat brain.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1995, Volume: 15, Issue:4

    Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Calcium; Dizocilpine Maleate; Flunarizine; Glyburide; Heart Arrest; Hypoxia; Ion Channels; Male; Nimodipine; Piperidines; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Sodium; Thiazoles

1995
R56865 as Ca(2+)-channel blocker in Purkinje neurons of rat: comparison with flunarizine and nimodipine.
    Neuroscience, 1993, Volume: 54, Issue:3

    Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Electrophysiology; Evoked Potentials; Flunarizine; In Vitro Techniques; Nimodipine; Piperidines; Purkinje Cells; Rats; Rats, Wistar; Thiazoles

1993
R56865 and flunarizine as Na(+)-channel blockers in isolated Purkinje neurons of rat cerebellum.
    Neuroscience, 1993, Volume: 54, Issue:3

    Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cerebellum; Electric Stimulation; Electrophysiology; Flunarizine; In Vitro Techniques; Piperidines; Purkinje Cells; Rats; Rats, Wistar; Sodium Channels; Tetrodotoxin; Thiazoles

1993