osemozotan and buspirone
osemozotan has been researched along with buspirone in 4 studies
Compound Research Comparison
| Studies (osemozotan) | Trials (osemozotan) | Recent Studies (post-2010) (osemozotan) | Studies (buspirone) | Trials (buspirone) | Recent Studies (post-2010) (buspirone) |
|---|---|---|---|---|---|
| 32 | 0 | 4 | 2,096 | 351 | 382 |
Protein Interaction Comparison
| Protein | Taxonomy | osemozotan (IC50) | buspirone (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.025 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 1.75 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.024 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.323 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 2.125 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 4.16 | |
| D | Rattus norvegicus (Norway rat) | 0.12 | |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | 0.12 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.0266 | |
| D(2) dopamine receptor | Bos taurus (cattle) | 4 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 4.16 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.077 | |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | 0.12 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 2.286 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.016 | |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | 0.12 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 2.125 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.044 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.75 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 4.16 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 0.2055 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 3.9811 | |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | 0.025 | |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 1.7 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.2666 | |
| Lysosomal alpha-glucosidase | Bos taurus (cattle) | 0.03 |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Asano, S; Baba, A; Matsuda, T; Somboonthum, P; Suzuki, M; Takuma, K | 1 |
| Abe, M; Baba, A; Egawa, M; Matsuda, T; Saito, K; Tabata, R | 1 |
| Abe, M; Egawa, M; Nakai, H; Saito, K; Tabata, R | 1 |
| Aida, R; Akiyama, M; Moriya, T; Shibata, S; Shimomura, H; Takahashi, S; Yoshinobu, Y | 1 |
Other Studies
4 other study(ies) available for osemozotan and buspirone
| Article | Year |
|---|---|
Increase of noradrenaline release in the hypothalamus of freely moving rat by postsynaptic 5-hydroxytryptamine1A receptor activation.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dioxanes; Dioxoles; Drug Interactions; Hippocampus; Hypothalamus; Injections, Subcutaneous; Male; Microdialysis; Neurons; Norepinephrine; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tropanes | 1995 |
Novel benzodioxan derivative, 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl) amino]propoxy]-1,3-benzodioxole HCl (MKC-242), with anxiolytic-like and antidepressant-like effects in animal models.
Topics: Animals; Buspirone; Dioxanes; Dioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Male; Mice; Mice, Inbred Strains; Motor Activity; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists | 1996 |
Effect of 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole HCl (MKC-242), a novel 5-HT1A-receptor agonist, on aggressive behavior and marble burying behavior in mice.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Diazepam; Dioxanes; Dioxoles; Disease Models, Animal; Drug Evaluation, Preclinical; Isoindoles; Male; Mice; Mice, Inbred ICR; Obsessive Behavior; Piperazines; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1998 |
Extended action of MKC-242, a selective 5-HT(1A) receptor agonist, on light-induced Per gene expression in the suprachiasmatic nucleus in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Cell Cycle Proteins; Circadian Rhythm; Diazepam; Dioxanes; Dioxoles; GABA Modulators; Gene Expression Regulation; In Situ Hybridization; Light; Male; Mice; Motor Activity; Nuclear Proteins; Paroxetine; Period Circadian Proteins; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Suprachiasmatic Nucleus; Transcription Factors | 2002 |