biotin and camptothecin
biotin has been researched along with camptothecin in 18 studies
Compound Research Comparison
| Studies (biotin) | Trials (biotin) | Recent Studies (post-2010) (biotin) | Studies (camptothecin) | Trials (camptothecin) | Recent Studies (post-2010) (camptothecin) |
|---|---|---|---|---|---|
| 14,847 | 95 | 3,882 | 13,002 | 2,229 | 5,391 |
Protein Interaction Comparison
| Protein | Taxonomy | biotin (IC50) | camptothecin (IC50) |
|---|---|---|---|
| Histone deacetylase 3 | Homo sapiens (human) | 0.05 | |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | 7.4 | |
| DNA topoisomerase 1 | Homo sapiens (human) | 1.9799 | |
| Somatostatin receptor type 1 | Homo sapiens (human) | 0.0022 | |
| Somatostatin receptor type 2 | Homo sapiens (human) | 0.0022 | |
| Somatostatin receptor type 4 | Homo sapiens (human) | 0.0022 | |
| Somatostatin receptor type 3 | Homo sapiens (human) | 0.0022 | |
| Somatostatin receptor type 5 | Homo sapiens (human) | 0.0022 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.97 | |
| Histone deacetylase 4 | Homo sapiens (human) | 0.05 | |
| Histone deacetylase 1 | Homo sapiens (human) | 0.05 | |
| Histone deacetylase 7 | Homo sapiens (human) | 0.05 | |
| Histone deacetylase 2 | Homo sapiens (human) | 0.05 | |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | 0.05 | |
| Histone deacetylase 11 | Homo sapiens (human) | 0.05 | |
| Histone deacetylase 8 | Homo sapiens (human) | 0.05 | |
| Histone deacetylase 6 | Homo sapiens (human) | 0.05 | |
| Histone deacetylase 9 | Homo sapiens (human) | 0.05 | |
| Histone deacetylase 5 | Homo sapiens (human) | 0.05 |
Research
Studies (18)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cao, SL; Jiang, W; Li, J; Li, YS; Li, Z; Liao, J; Peng, B; Ren, TT; Wang, FC; Wang, G; Wang, H; Xu, S; Xu, X; Yang, CR | 1 |
| Darzynkiewicz, Z; James, WM; Li, X; Traganos, F | 1 |
| Lerner, CG; Saiki, AY | 1 |
| Basi, GS; Earnshaw, WC; Eischen, CM; Kaufmann, SH; Kottke, TJ; Leibson, PJ; Martins, LM; Tung, JS | 1 |
| Joshi, B; Li, L; Tang, DG; Zhu, Z | 1 |
| Enomoto, T; Kobayashi, T; Murofushi, H; Seki, M; Tada, S; Tsuyama, T | 1 |
| Amessou, M; Decaudin, D; El Alaoui, A; Florent, JC; Johannes, L; Sarr, M; Schmidt, F | 1 |
| Kobayashi, S; Kuramochi, K; Sakaguchi, K; Sugawara, F; Takakusagi, K; Takakusagi, Y | 1 |
| Caruthers, SD; Gaffney, PJ; Hu, G; Lanza, GM; Pan, D; Scott, MJ; Senpan, A; Wickline, SA | 1 |
| Chen, YJ; Kamath, A; Ojima, I; Seitz, JD; Vineberg, JG; Zuniga, ES | 1 |
| Liu, Z; Xiong, X; Yan, B; Yang, A; Zhou, M | 1 |
| Amini, M; Atyabi, F; Baharian, A; Dinarvand, R; Ghahremani, MH; Gharghabi, M; Mehdizadeh, M; Ostad, SN; Rouhani, H; Sepehri, N; Varshochian, R | 1 |
| Cincinelli, R; Dallavalle, S; De Santis, R; Giannini, G; Minenkova, O; Musso, L; Santapaola, D; Vesci, L | 1 |
| Ding, R; Li, Z; Wang, J; Wang, M; Zhao, Z; Zhu, X | 1 |
| Dhiman, S; Kaur, A; Lee, HB; Sharma, M | 1 |
| Motohashi, Y; Nishihara, T; Tanabe, K | 1 |
| Chen, Y; Dai, Y; Ye, T; Zhang, Y | 1 |
Other Studies
18 other study(ies) available for biotin and camptothecin
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position.
Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Thiocarbamates; Tumor Cells, Cultured | 2018 |
Application of biotin, digoxigenin or fluorescein conjugated deoxynucleotides to label DNA strand breaks for analysis of cell proliferation and apoptosis using flow cytometry.
Topics: Apoptosis; Biotin; Bone Marrow; Bromodeoxyuridine; Camptothecin; Cell Division; Deoxyuracil Nucleotides; Digoxigenin; DNA; DNA Nucleotidylexotransferase; DNA Probes; Flow Cytometry; Fluoresceins; HL-60 Cells; Humans; Immunohistochemistry; Indicators and Reagents; Reagent Kits, Diagnostic | 1995 |
Scintillation proximity assay for human DNA topoisomerase I using recombinant biotinyl-fusion protein produced in baculovirus-infected insect cells.
Topics: Animals; Bacterial Proteins; Baculoviridae; Biotin; Camptothecin; Cells, Cultured; DNA; DNA Topoisomerases, Type I; Genetic Vectors; Humans; Plasmids; Recombinant Fusion Proteins; Scintillation Counting; Spodoptera; Streptavidin; Tritium | 1996 |
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.
Topics: Affinity Labels; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Biotin; Camptothecin; Caspase 3; Caspase 7; Caspases; Cisplatin; Cysteine Endopeptidases; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Lamin Type B; Lamins; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Methotrexate; Neoplasm Proteins; Nuclear Proteins; Oligopeptides; Poly(ADP-ribose) Polymerases; Staurosporine; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured | 1997 |
Apoptosis in the absence of cytochrome c accumulation in the cytosol.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Biotin; Bleomycin; Blotting, Western; Camptothecin; Cytochrome c Group; Cytosol; Enzyme Inhibitors; Etoposide; Humans; Hydroxamic Acids; Lymphoma; Microscopy, Fluorescence; Mitochondria; Phalloidine; Poly(ADP-ribose) Polymerases; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vinblastine | 1998 |
Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Biotin; Caffeine; Camptothecin; Cell Cycle Proteins; Cell Extracts; Cell Nucleus; Cell-Free System; Deoxyuracil Nucleotides; DNA Damage; DNA Repair; DNA-Binding Proteins; Eukaryotic Cells; Female; Geminin; Genes, cdc; Male; Oocytes; Protein Serine-Threonine Kinases; Replication Protein A; Site-Specific DNA-Methyltransferase (Adenine-Specific); Spermatozoa; Tumor Suppressor Proteins; Xenopus laevis; Xenopus Proteins | 2002 |
Shiga toxin-mediated retrograde delivery of a topoisomerase I inhibitor prodrug.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biotin; Camptothecin; CHO Cells; Cricetinae; Cricetulus; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; HT29 Cells; Humans; Irinotecan; Prodrugs; Shiga Toxin; Shiga Toxins; Topoisomerase II Inhibitors; Trihexosylceramides | 2007 |
Identification of C10 biotinylated camptothecin (CPT-10-B) binding peptides using T7 phage display screen on a QCM device.
Topics: Amino Acid Sequence; Antineoplastic Agents; Bacteriophage T7; Biosensing Techniques; Biotin; Biotinylation; Camptothecin; Humans; Molecular Conformation; Molecular Sequence Data; Peptide Library; Peptides; Protein Binding | 2007 |
Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance imaging of vascular targets.
Topics: Biotin; Camptothecin; Doxorubicin; Drug Delivery Systems; Fibrin; Humans; Magnetic Resonance Angiography; Manganese; Micelles; Microscopy, Atomic Force; Nanoparticles; Organometallic Compounds | 2008 |
Design, synthesis, and biological evaluations of tumor-targeting dual-warhead conjugates for a taxoid-camptothecin combination chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biotin; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Click Chemistry; Female; Glutathione; Humans; Inhibitory Concentration 50; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Targeted Therapy; Receptors, Growth Factor; Taxoids | 2014 |
Preparation of camptothecin-loaded targeting nanoparticles and their antitumor effects on hepatocellular carcinoma cell line H22.
Topics: Antineoplastic Agents; Biotin; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Humans; Nanoparticles; Polymers; Solubility; Tissue Distribution; Xenograft Model Antitumor Assays | 2016 |
Biotin decorated PLGA nanoparticles containing SN-38 designed for cancer therapy.
Topics: Antineoplastic Agents, Phytogenic; Biological Transport; Biotin; Camptothecin; Cell Survival; Drug Carriers; Drug Compounding; Drug Liberation; Female; Humans; Hydrogen-Ion Concentration; Irinotecan; Kinetics; Lactic Acid; MCF-7 Cells; Nanoparticles; Particle Size; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2017 |
Growth inhibition of human ovarian carcinoma by a novel AvidinOX-anchored biotinylated camptothecin derivative.
Topics: Animals; Antineoplastic Agents; Avidin; Biotin; Camptothecin; Carcinoma; Cell Line, Tumor; Cell Proliferation; Female; Humans; Mice; Ovarian Neoplasms; Protein Binding | 2018 |
Design and Synthesis of Galactose-Biotin Lipid Materials for Liposomes to Promote the Hepatoma Cell-Targeting Effect.
Topics: Antineoplastic Agents; Asialoglycoprotein Receptor; Biotin; Camptothecin; Carcinoma, Hepatocellular; Drug Carriers; Drug Liberation; Drug Screening Assays, Antitumor; Galactose; Hep G2 Cells; Hepatocytes; Humans; Lipids; Liposomes; Liver Neoplasms; Particle Size | 2019 |
Synthesis and Antitumor Evaluation of Glutathione Responsive Self-Immolative Disulphide Linked Camptothecin-Biotin Conjugate.
Topics: Animals; Antineoplastic Agents; Biotin; Camptothecin; Disulfides; Glutathione; Rats; Rats, Wistar | 2022 |
Preparation of a multifunctional photoactivated prodrug on a streptavidin scaffold bearing a DNA aptamer.
Topics: Antineoplastic Agents; Aptamers, Nucleotide; Biotin; Camptothecin; Epithelial Cell Adhesion Molecule; Prodrugs; Streptavidin | 2022 |
Synthesis and Antitumor Evaluation of Biotin-SN38-Valproic Acid Conjugates.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biotin; Camptothecin; Cell Line, Tumor; Fibroblasts; HeLa Cells; Humans; Irinotecan; Mice; NIH 3T3 Cells; Valproic Acid | 2023 |