Page last updated: 2024-09-05

biotin and camptothecin

biotin has been researched along with camptothecin in 18 studies

Compound Research Comparison

Studies
(biotin)
Trials
(biotin)
Recent Studies (post-2010)
(biotin)
Studies
(camptothecin)
Trials
(camptothecin)
Recent Studies (post-2010) (camptothecin)
14,847953,88213,0022,2295,391

Protein Interaction Comparison

ProteinTaxonomybiotin (IC50)camptothecin (IC50)
Histone deacetylase 3Homo sapiens (human)0.05
Multidrug resistance-associated protein 4Homo sapiens (human)7.4
DNA topoisomerase 1Homo sapiens (human)1.9799
Somatostatin receptor type 1Homo sapiens (human)0.0022
Somatostatin receptor type 2Homo sapiens (human)0.0022
Somatostatin receptor type 4Homo sapiens (human)0.0022
Somatostatin receptor type 3Homo sapiens (human)0.0022
Somatostatin receptor type 5Homo sapiens (human)0.0022
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.97
Histone deacetylase 4Homo sapiens (human)0.05
Histone deacetylase 1Homo sapiens (human)0.05
Histone deacetylase 7Homo sapiens (human)0.05
Histone deacetylase 2Homo sapiens (human)0.05
Polyamine deacetylase HDAC10Homo sapiens (human)0.05
Histone deacetylase 11 Homo sapiens (human)0.05
Histone deacetylase 8Homo sapiens (human)0.05
Histone deacetylase 6Homo sapiens (human)0.05
Histone deacetylase 9Homo sapiens (human)0.05
Histone deacetylase 5Homo sapiens (human)0.05

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (22.22)18.2507
2000's4 (22.22)29.6817
2010's7 (38.89)24.3611
2020's3 (16.67)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Cao, SL; Jiang, W; Li, J; Li, YS; Li, Z; Liao, J; Peng, B; Ren, TT; Wang, FC; Wang, G; Wang, H; Xu, S; Xu, X; Yang, CR1
Darzynkiewicz, Z; James, WM; Li, X; Traganos, F1
Lerner, CG; Saiki, AY1
Basi, GS; Earnshaw, WC; Eischen, CM; Kaufmann, SH; Kottke, TJ; Leibson, PJ; Martins, LM; Tung, JS1
Joshi, B; Li, L; Tang, DG; Zhu, Z1
Enomoto, T; Kobayashi, T; Murofushi, H; Seki, M; Tada, S; Tsuyama, T1
Amessou, M; Decaudin, D; El Alaoui, A; Florent, JC; Johannes, L; Sarr, M; Schmidt, F1
Kobayashi, S; Kuramochi, K; Sakaguchi, K; Sugawara, F; Takakusagi, K; Takakusagi, Y1
Caruthers, SD; Gaffney, PJ; Hu, G; Lanza, GM; Pan, D; Scott, MJ; Senpan, A; Wickline, SA1
Chen, YJ; Kamath, A; Ojima, I; Seitz, JD; Vineberg, JG; Zuniga, ES1
Liu, Z; Xiong, X; Yan, B; Yang, A; Zhou, M1
Amini, M; Atyabi, F; Baharian, A; Dinarvand, R; Ghahremani, MH; Gharghabi, M; Mehdizadeh, M; Ostad, SN; Rouhani, H; Sepehri, N; Varshochian, R1
Cincinelli, R; Dallavalle, S; De Santis, R; Giannini, G; Minenkova, O; Musso, L; Santapaola, D; Vesci, L1
Ding, R; Li, Z; Wang, J; Wang, M; Zhao, Z; Zhu, X1
Dhiman, S; Kaur, A; Lee, HB; Sharma, M1
Motohashi, Y; Nishihara, T; Tanabe, K1
Chen, Y; Dai, Y; Ye, T; Zhang, Y1

Other Studies

18 other study(ies) available for biotin and camptothecin

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position.
    European journal of medicinal chemistry, 2018, Jun-25, Volume: 154

    Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Thiocarbamates; Tumor Cells, Cultured

2018
Application of biotin, digoxigenin or fluorescein conjugated deoxynucleotides to label DNA strand breaks for analysis of cell proliferation and apoptosis using flow cytometry.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 1995, Volume: 70, Issue:5

    Topics: Apoptosis; Biotin; Bone Marrow; Bromodeoxyuridine; Camptothecin; Cell Division; Deoxyuracil Nucleotides; Digoxigenin; DNA; DNA Nucleotidylexotransferase; DNA Probes; Flow Cytometry; Fluoresceins; HL-60 Cells; Humans; Immunohistochemistry; Indicators and Reagents; Reagent Kits, Diagnostic

1995
Scintillation proximity assay for human DNA topoisomerase I using recombinant biotinyl-fusion protein produced in baculovirus-infected insect cells.
    Analytical biochemistry, 1996, Sep-05, Volume: 240, Issue:2

    Topics: Animals; Bacterial Proteins; Baculoviridae; Biotin; Camptothecin; Cells, Cultured; DNA; DNA Topoisomerases, Type I; Genetic Vectors; Humans; Plasmids; Recombinant Fusion Proteins; Scintillation Counting; Spodoptera; Streptavidin; Tritium

1996
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.
    Blood, 1997, Aug-01, Volume: 90, Issue:3

    Topics: Affinity Labels; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Biotin; Camptothecin; Caspase 3; Caspase 7; Caspases; Cisplatin; Cysteine Endopeptidases; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Lamin Type B; Lamins; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Methotrexate; Neoplasm Proteins; Nuclear Proteins; Oligopeptides; Poly(ADP-ribose) Polymerases; Staurosporine; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured

1997
Apoptosis in the absence of cytochrome c accumulation in the cytosol.
    Biochemical and biophysical research communications, 1998, Jan-14, Volume: 242, Issue:2

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Biotin; Bleomycin; Blotting, Western; Camptothecin; Cytochrome c Group; Cytosol; Enzyme Inhibitors; Etoposide; Humans; Hydroxamic Acids; Lymphoma; Microscopy, Fluorescence; Mitochondria; Phalloidine; Poly(ADP-ribose) Polymerases; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vinblastine

1998
Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract.
    Journal of cell science, 2002, Aug-01, Volume: 115, Issue:Pt 15

    Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Biotin; Caffeine; Camptothecin; Cell Cycle Proteins; Cell Extracts; Cell Nucleus; Cell-Free System; Deoxyuracil Nucleotides; DNA Damage; DNA Repair; DNA-Binding Proteins; Eukaryotic Cells; Female; Geminin; Genes, cdc; Male; Oocytes; Protein Serine-Threonine Kinases; Replication Protein A; Site-Specific DNA-Methyltransferase (Adenine-Specific); Spermatozoa; Tumor Suppressor Proteins; Xenopus laevis; Xenopus Proteins

2002
Shiga toxin-mediated retrograde delivery of a topoisomerase I inhibitor prodrug.
    Angewandte Chemie (International ed. in English), 2007, Volume: 46, Issue:34

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biotin; Camptothecin; CHO Cells; Cricetinae; Cricetulus; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; HT29 Cells; Humans; Irinotecan; Prodrugs; Shiga Toxin; Shiga Toxins; Topoisomerase II Inhibitors; Trihexosylceramides

2007
Identification of C10 biotinylated camptothecin (CPT-10-B) binding peptides using T7 phage display screen on a QCM device.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Amino Acid Sequence; Antineoplastic Agents; Bacteriophage T7; Biosensing Techniques; Biotin; Biotinylation; Camptothecin; Humans; Molecular Conformation; Molecular Sequence Data; Peptide Library; Peptides; Protein Binding

2007
Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance imaging of vascular targets.
    Journal of the American Chemical Society, 2008, Jul-23, Volume: 130, Issue:29

    Topics: Biotin; Camptothecin; Doxorubicin; Drug Delivery Systems; Fibrin; Humans; Magnetic Resonance Angiography; Manganese; Micelles; Microscopy, Atomic Force; Nanoparticles; Organometallic Compounds

2008
Design, synthesis, and biological evaluations of tumor-targeting dual-warhead conjugates for a taxoid-camptothecin combination chemotherapy.
    Journal of medicinal chemistry, 2014, Jul-10, Volume: 57, Issue:13

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biotin; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Click Chemistry; Female; Glutathione; Humans; Inhibitory Concentration 50; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Targeted Therapy; Receptors, Growth Factor; Taxoids

2014
Preparation of camptothecin-loaded targeting nanoparticles and their antitumor effects on hepatocellular carcinoma cell line H22.
    Drug delivery, 2016, Volume: 23, Issue:5

    Topics: Antineoplastic Agents; Biotin; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Humans; Nanoparticles; Polymers; Solubility; Tissue Distribution; Xenograft Model Antitumor Assays

2016
Biotin decorated PLGA nanoparticles containing SN-38 designed for cancer therapy.
    Artificial cells, nanomedicine, and biotechnology, 2017, Volume: 45, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Biological Transport; Biotin; Camptothecin; Cell Survival; Drug Carriers; Drug Compounding; Drug Liberation; Female; Humans; Hydrogen-Ion Concentration; Irinotecan; Kinetics; Lactic Acid; MCF-7 Cells; Nanoparticles; Particle Size; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer

2017
Growth inhibition of human ovarian carcinoma by a novel AvidinOX-anchored biotinylated camptothecin derivative.
    Bioorganic & medicinal chemistry letters, 2018, 11-01, Volume: 28, Issue:20

    Topics: Animals; Antineoplastic Agents; Avidin; Biotin; Camptothecin; Carcinoma; Cell Line, Tumor; Cell Proliferation; Female; Humans; Mice; Ovarian Neoplasms; Protein Binding

2018
Design and Synthesis of Galactose-Biotin Lipid Materials for Liposomes to Promote the Hepatoma Cell-Targeting Effect.
    Journal of pharmaceutical sciences, 2019, Volume: 108, Issue:9

    Topics: Antineoplastic Agents; Asialoglycoprotein Receptor; Biotin; Camptothecin; Carcinoma, Hepatocellular; Drug Carriers; Drug Liberation; Drug Screening Assays, Antitumor; Galactose; Hep G2 Cells; Hepatocytes; Humans; Lipids; Liposomes; Liver Neoplasms; Particle Size

2019
Synthesis and Antitumor Evaluation of Glutathione Responsive Self-Immolative Disulphide Linked Camptothecin-Biotin Conjugate.
    Anti-cancer agents in medicinal chemistry, 2022, Volume: 22, Issue:18

    Topics: Animals; Antineoplastic Agents; Biotin; Camptothecin; Disulfides; Glutathione; Rats; Rats, Wistar

2022
Preparation of a multifunctional photoactivated prodrug on a streptavidin scaffold bearing a DNA aptamer.
    Bioorganic & medicinal chemistry letters, 2022, 09-01, Volume: 71

    Topics: Antineoplastic Agents; Aptamers, Nucleotide; Biotin; Camptothecin; Epithelial Cell Adhesion Molecule; Prodrugs; Streptavidin

2022
Synthesis and Antitumor Evaluation of Biotin-SN38-Valproic Acid Conjugates.
    Molecules (Basel, Switzerland), 2023, May-07, Volume: 28, Issue:9

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biotin; Camptothecin; Cell Line, Tumor; Fibroblasts; HeLa Cells; Humans; Irinotecan; Mice; NIH 3T3 Cells; Valproic Acid

2023