yunaconitine: alkaloid found in folk medicine caowu; RN given refers to (1alpha,3alpha,6alpha,14alpha,16beta)-isomer; RN for cpd without isomeric designation not avail 8/91 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
yunaconitine : A diterpene alkaloid with formula C35H49NO11 that is isolated from several Aconitum species. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Aconitum | genus | A plant genus of the family RANUNCULACEAE. Members contain a number of diterpenoid alkaloids including: aconitans, hypaconitine, ACONITINE, jesaconitine, ignavine, napelline, and mesaconitine. The common name of Wolfbane is similar to the common name for ARNICA.[MeSH] | Ranunculaceae | The buttercup plant family of the order RANUNCULALES, class MAGNOLIOPSIDA. The leaves are usually alternate and stalkless. The flowers usually have two to five free sepals and may be radially symmetrical or irregular.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 6918110 |
| CHEMBL ID | 2227789 |
| CHEBI ID | 132640 |
| SCHEMBL ID | 7132822 |
| MeSH ID | M0190458 |
| Synonym |
|---|
| 3-alpha,13-dihydroxyforesaconitine |
| guayewuanine b |
| YAC , |
| yunaconitine |
| CHEBI:132640 |
| 8-(acetyloxy)-20-ethyl-3alpha,13-dihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitan-14alpha-yl 4-methoxybenzoate |
| 70578-24-4 |
| (1alpha,3alpha,6alpha,14alpha,16beta)-8-(acetyloxy)-20-ethyl-3,13-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl 4-methoxybenzoate |
| SCHEMBL7132822 |
| CHEMBL2227789 |
| [(1s,2r,3r,4r,5s,6s,8r,9r,13r,14r,16s,17s,18r)-8-acetyloxy-11-ethyl-5,14-dihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] 4-methoxybenzoate |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The UPLC-MS/MS method developed herein was successfully applied to measuring the pharmacokinetic parameters of yunaconitine and indaconitine in mice after intravenous and oral administration." | ( Pharmacokinetics of yunaconitine and indaconitine in mouse blood by UPLC-MS/MS. Hu, Y; Liu, H; Wang, X; Wen, C; Xu, X; Yu, X, 2021) | 0.62 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The bioavailability of yunaconitine and indaconitine were 27." | ( Pharmacokinetics of yunaconitine and indaconitine in mouse blood by UPLC-MS/MS. Hu, Y; Liu, H; Wang, X; Wen, C; Xu, X; Yu, X, 2021) | 0.62 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " Laboratory investigation into suspected intoxication cases is challenging because the content of toxic aconitum alkaloids varies depending on the plant source, market processing, dosing protocol, hydrolytic degradation, and metabolic transformation." | ( Hidden aconite poisoning: identification of yunaconitine and related aconitum alkaloids in urine by liquid chromatography-tandem mass spectrometry. Chan, YW; Lai, CK; Poon, WT, 2006) | 0.33 |
| "This work disclosed that crassicauline A is elimilated in rats predominantly by metabolism under toxic dosage and the hydroxylation probably at C-15 might be a potential bioactivation pathway in both rats and human." | ( Hydroxylation Metabolisms of Crassicauline A in Rats Under Toxic Dose. Fan, X; Lan, K; Li, XJ; Xu, L; Yang, K; Yin, SS, 2017) | 0.46 |
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| phytotoxin | Any toxin produced by a plant. |
| antifeedant | A substance that prevents pests from feeding. |
| human urinary metabolite | Any metabolite (endogenous or exogenous) found in human urine samples. |
| xenobiotic | A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| acetate ester | Any carboxylic ester where the carboxylic acid component is acetic acid. |
| aromatic ether | Any ether in which the oxygen is attached to at least one aryl substituent. |
| benzoate ester | Esters of benzoic acid or substituted benzoic acids. |
| bridged compound | A polycyclic compound in which two rings have two or more atoms in common. |
| diterpene alkaloid | |
| organic heteropolycyclic compound | |
| polyether | Any ether that contains more than one ether linkage. |
| tertiary amino compound | A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups. |
| secondary alcohol | A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it. |
| tertiary alcohol | A tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1082008 | Toxicity in po dosed Mus musculus (mouse) | 2011 | Journal of agricultural and food chemistry, Apr-27, Volume: 59, Issue:8 | Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum. |
| AID1082013 | Feeding deterrent activity against Tribolium castaneum (red flour beetle) adults using wheat flour assessed as consumption of diet at 100 ppm measured after 3 days relative to untreated control | 2011 | Journal of agricultural and food chemistry, Apr-27, Volume: 59, Issue:8 | Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum. |
| AID1082011 | Feeding deterrent activity against Tribolium castaneum (red flour beetle) adults using wheat flour assessed as consumption of diet at 10 ppm measured after 3 days relative to untreated control | 2011 | Journal of agricultural and food chemistry, Apr-27, Volume: 59, Issue:8 | Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum. |
| AID1082012 | Feeding deterrent activity against Tribolium castaneum (red flour beetle) adults using wheat flour assessed as consumption of diet at 30 ppm measured after 3 days relative to untreated control | 2011 | Journal of agricultural and food chemistry, Apr-27, Volume: 59, Issue:8 | Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum. |
| AID1082014 | Feeding deterrent activity against Tribolium castaneum (red flour beetle) adults using wheat flour assessed as inhibition of insect feeding measured after 3 days | 2011 | Journal of agricultural and food chemistry, Apr-27, Volume: 59, Issue:8 | Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 9 (45.00) | 24.3611 |
| 2020's | 4 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (5.00%) | 6.00% |
| Case Studies | 1 (5.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 18 (90.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||