xestoaminol c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

xestoaminol C: a metabolite of Fiji sponge, Xestospongia sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

1-deoxytetradecasphinganine : A sphingoid that is tetradecasphinganine in which the terminal hydroxy group has been replaced by a hydrogen. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	14756407
CHEMBL ID	448146
CHEBI ID	73882
SCHEMBL ID	5271731
MeSH ID	M0452775

Synonyms (13)

Synonym
LMSP01080033
xestoaminol c
1-deoxy-tetradecasphinganine
CHEMBL448146
(2s,3r)-xestoaminol c
chebi:73882 ,
(2s,3r)-2-aminotetradecan-3-ol
1-deoxytetradecasphinganine
WMUMHAZHWIUBPN-UONOGXRCSA-N
(2s,3r)-2-amino-3-tetradecanol
SCHEMBL5271731
Q27144207
DTXSID001025435

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

Class	Description
sphingoid	Sphinganine, its homologs and stereoisomers, and the hydroxy and unsaturated derivatives of these compounds.
amino alcohol	An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID623346	Cytotoxicity against human SHG44 at 50 uM after 24 hrs by cell counting kit-8 assay	2011	European journal of medicinal chemistry, Nov, Volume: 46, Issue:11	Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols.
AID623348	Antiproliferative activity against human SHG44 cells after 24 hrs by cell counting kit-8 assay	2011	European journal of medicinal chemistry, Nov, Volume: 46, Issue:11	Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols.
AID336239	Inhibition of reverse transcriptase at 1 mg/ml
AID623347	Growth inhibition of human SHG44 at 10 uM after 24 hrs by cell counting kit-8 assay	2011	European journal of medicinal chemistry, Nov, Volume: 46, Issue:11	Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (50.00)	29.6817
2010's	3 (50.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	19.92 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.37 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (19.92)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
2-aminoethoxydiphenyl borate 2-aminoethoxydiphenyl borate: is a novel membrane-penetrable modulator and transient receptor potential channel blocker; structure in first source; do not confuse with 2-APB cpd. 2-aminoethoxydiphenylborane : An organoboron compound that is diphenylborane in which the borane hydrogen is replaced by a 2-aminoethoxy group.	2.03	1	organoboron compound; primary amino compound	calcium channel blocker; IP3 receptor antagonist; potassium channel opener
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	2.01	1	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
egtazic acid Egtazic Acid: A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.. ethylene glycol bis(2-aminoethyl)tetraacetic acid : A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.	2.03	1	diether; tertiary amino compound; tetracarboxylic acid	chelator
1,2-bis(2-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: structure in first source	2.03	1	polyamino carboxylic acid; tetracarboxylic acid	chelator
safingol safingol: RN given refers to the (R-(R,S))-isomer	2.04	1	amino alcohol
sphingosine sphing-4-enine : A sphingenine in which the C=C double bond is located at the 4-position.. sphingenine : A 2-aminooctadecene-1,3-diol having (2S,3R)-configuration.. sphingoid : Sphinganine, its homologs and stereoisomers, and the hydroxy and unsaturated derivatives of these compounds.. 2-aminooctadec-4-ene-1,3-diol : A 2-aminooctadecene-1,3-diol having its double bond at position 4.	7.46	2	sphing-4-enine	human metabolite; mouse metabolite

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