| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID660351 | Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassay | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID660521 | Genotoxicity against TK-negative mouse L5178Y cells | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID660354 | Fraction unbound in cynomolgus monkey plasma | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID660353 | Fraction unbound in dog plasma | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID1668159 | Inhibition of renin (unknown origin) relative to control | 2020 | Bioorganic & medicinal chemistry, 05-15, Volume: 28, Issue:10
| Decades-old renin inhibitors are still struggling to find a niche in antihypertensive therapy. A fleeting look at the old and the promising new molecules. |
| AID660518 | Mutagenicity against Salmonella typhimurium in the presence of S9-mix | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID660352 | Inhibition of CYP3A4 using testosterone as substrate in human liver microsome for 20 mins by HPLC analysis | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID660522 | Antihypertensive activity in double transgenic rat expressing human renin assessed as reduction in mean arterial blood pressure at 10 mg/kg, po after 24 hrs | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID660349 | Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetry | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID660515 | Inhibition of human recombinant cathepsin E using Mca-GKPILFFRLK(Dnp)-D-Arg-NH2 as substrate at 10 uM incubated for 10 mins prior to substrate addition measured for 1 hr by FRET analysis | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID660520 | Genotoxicity against TK-positive mouse L5178Y cells | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID660517 | Inhibition of BACE using SEVNLDAEFK(Dnp)NH2 as substrate at 10 uM incubated for 10 mins prior to substrate addition measured for 1 hr by FRET analysis | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID537695 | Inhibition of renin in plasma | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Direct renin inhibitors as a new therapy for hypertension. |
| AID660516 | Inhibition of human cathepsin D using Mca-GKPILFFRLK(Dnp)-D-Arg-NH2 as substrate at 10 uM incubated for 10 mins prior to substrate addition measured for 1 hr by FRET analysis | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID1193304 | Inhibition of renin (unknown origin) | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
| Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors. |
| AID660350 | Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiotensin1 product after 2 hrs by competive radioimmunoassay | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| AID660519 | Mutagenicity against Salmonella typhimurium in the absence of S9-mix | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
| Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |