| Assay ID | Title | Year | Journal | Article |
|---|
| AID1058162 | Selectivity ratio of IC50 for Tyro-3 kinase (unknown origin) to IC50 for Mer kinase (unknown origin) | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058164 | Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058150 | Inhibition of Mer kinase phosphorylation in human Colo699 cells after 72 hrs by Western blot analysis | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058158 | Clearance in mouse at 3 mg/kg, iv | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058167 | Antiproliferative activity against human BT-12 cells assessed as inhibition of colony formation at 30 nM to 3 uM after 3 weeks by thiazolyl blue tetrazolium bromide staining | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058152 | AUClast in mouse at 3 mg/kg, po | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058163 | Selectivity ratio of IC50 for Axl kinase (unknown origin) to IC50 for Mer kinase (unknown origin) | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058156 | Tmax in mouse at 3 mg/kg, po | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058155 | Antiproliferative activity against human COLO699 cells assessed as inhibition of colony formation at 30 nM to 3 uM after 2 weeks by nitrotetrazolium blue chloride staining | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058160 | AUClast in mouse at 3 mg/kg, iv | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058151 | Inhibition of Mer kinase phosphorylation in human 697 B-ALL cells after 1 hr by Western blot analysis | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058161 | Half life in mouse at 3 mg/kg, iv | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058149 | Inhibition of EGF-induced human intracellular domain of Mer/extracellular domain of EGFR phosphorylation expressed in mouse 32D-EMC cells up to 3000 nM after 1 hr by Western blot analysis | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058153 | Oral bioavailability in mouse at 3 mg/kg | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058154 | Cmax in mouse at 3 mg/kg, po | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058159 | Cmax in mouse at 3 mg/kg, iv | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058157 | Volume of distribution at steady state in mouse at 3 mg/kg, iv | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058166 | Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1058165 | Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay | 2013 | Journal of medicinal chemistry, Dec-12, Volume: 56, Issue:23
| Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |