Page last updated: 2024-12-07
thiram ef
Description
Thiram, also known as tetramethylthiuram disulfide, is a fungicide and acaricide widely used in agriculture to protect crops from fungal diseases. It is synthesized through a reaction between carbon disulfide and dimethylamine, producing tetramethylthiuram monosulfide, which is then oxidized to form thiram. Thiram is a broad-spectrum fungicide, effective against a range of fungal pathogens. It is known for its contact action, meaning it inhibits fungal growth upon contact. Thiram's mode of action involves interfering with the electron transport chain in fungal cells, disrupting their energy production. While thiram has been widely used due to its effectiveness, concerns have been raised about its potential toxicity to humans and the environment. Thiram is considered moderately toxic, and exposure can cause skin irritation, eye irritation, and respiratory problems. It has also been linked to developmental and reproductive effects in animals. Due to its potential toxicity and environmental concerns, the use of thiram is being reevaluated in many regions. Research on thiram focuses on understanding its environmental fate, developing safer alternatives, and exploring its potential for other applications, such as its use as a vulcanizing agent in rubber production. '
thiram EF: vulcanizing agent for rubbers used for food packaging; RN given refers to (N,N'-diethyl-N,N'-diphenyl)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 93230 |
| SCHEMBL ID | 1024200 |
| MeSH ID | M0081669 |
Synonyms (18)
| Synonym |
|---|
| n,n'-diethyl-n,n'-diphenylthioperoxydicarbamic acid |
| ekagon te |
| thiuram ef |
| thioperoxydicarbonic diamide, n,n'-diethyl-n,n'-diphenyl- |
| thiram ef |
| diethyldiphenylthiuram disulfide |
| n,n-diethyl-n,n-diphenylthiuramdisulfide |
| brn 3011487 |
| einecs 255-335-7 |
| n,n'-diethyl-n,n'-diphenylthioperoxydicarbonic diamide (((h2n)c(s))2s2) |
| 41365-24-6 |
| [ethyl({[ethyl(phenyl)carbamothioyl]disulfanyl}carbothioyl)amino]benzene |
| [ethyl(phenyl)carbamothioyl]sulfanyl n-ethyl-n-phenylcarbamodithioate |
| 4-12-00-00846 (beilstein handbook reference) |
| SCHEMBL1024200 |
| n-ethyl-n- phenyl{[ethyl(phenyl)carbamothioyl]disulfanyl}carbothioamide |
| DTXSID701145387 |
| thioperoxydicarbonic diamide ([(h2n)c(s)]2s2), n,n'-diethyl-n,n'-diphenyl- |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.51
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.51 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.31 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 1 (20.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |